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4BCR

Structure of PPARalpha in complex with WY14643

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0004879molecular_functionnuclear receptor activity
A0005634cellular_componentnucleus
A0006355biological_processregulation of DNA-templated transcription
B0003677molecular_functionDNA binding
B0004879molecular_functionnuclear receptor activity
B0005634cellular_componentnucleus
B0006355biological_processregulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues2
DetailsBINDING SITE FOR RESIDUE EDO A 1467
ChainResidue
APRO238
APHE338

site_idAC2
Number of Residues14
DetailsBINDING SITE FOR RESIDUE WY1 A 1468
ChainResidue
ALEU321
AMET330
AILE354
AMET355
ALYS358
AHIS440
ATYR464
ACYS276
ATHR279
ASER280
ATHR283
ATYR314
AILE317
APHE318

site_idAC3
Number of Residues10
DetailsBINDING SITE FOR RESIDUE WY1 A 1469
ChainResidue
AGLU251
AVAL255
ALEU258
ALYS266
AARG271
AILE272
AHIS274
ACYS275
ACYS278
APHE421

site_idAC4
Number of Residues13
DetailsBINDING SITE FOR RESIDUE WY1 B 1468
ChainResidue
BCYS276
BGLN277
BTHR279
BSER280
BTHR283
BTYR314
BPHE318
BMET330
BMET355
BLYS358
BHIS440
BLEU460
BTYR464

site_idAC5
Number of Residues8
DetailsBINDING SITE FOR RESIDUE WY1 B 1470
ChainResidue
BGLU251
BLYS266
BARG271
BILE272
BHIS274
BCYS275
BCYS278
BILE339

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:19116277, ECO:0007744|PDB:3ET1
ChainResidueDetails
ASER280
ATYR314
ATYR464
BSER280
BTYR314
BTYR464

site_idSWS_FT_FI2
Number of Residues2
DetailsSITE: Essential for heterodimerization with RXRA
ChainResidueDetails
ALEU433
BLEU433

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PDB entries from 2024-10-30

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