4BBA

Crystal structure of glucokinase regulatory protein complexed to phosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004857	molecular_function	enzyme inhibitor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006606	biological_process	protein import into nucleus
A	0009749	biological_process	response to glucose
A	0009750	biological_process	response to fructose
A	0019210	molecular_function	kinase inhibitor activity
A	0019899	molecular_function	enzyme binding
A	0030246	molecular_function	carbohydrate binding
A	0033132	biological_process	negative regulation of glucokinase activity
A	0042593	biological_process	glucose homeostasis
A	0046415	biological_process	urate metabolic process
A	0070095	molecular_function	fructose-6-phosphate binding
A	0070328	biological_process	triglyceride homeostasis
A	0097367	molecular_function	carbohydrate derivative binding
A	0141089	molecular_function	glucose sensor activity
A	1901135	biological_process	carbohydrate derivative metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PO4 A 701

Chain	Residue
A	SER109
A	HOH2176
A	HOH2194
A	SER178
A	VAL179
A	GLY180
A	ALA183
A	LYS513
A	HOH2116
A	HOH2117
A	HOH2122

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Functional Information from PROSITE/UniProt

site_id	PS01272
Number of Residues	18
Details	GCKR Glucokinase regulatory protein family signature. GPEgLSGSSRMKGGSatK

Chain	Residue	Details
A	GLY249-LYS266

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q07071

Chain	Residue	Details
A	THR108
A	SER178
A	LYS513

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:23621087, ECO:0007744|PDB:4BB9

Chain	Residue	Details
A	GLU152
A	GLU347

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