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4B9T

Structure of the high fidelity DNA polymerase I with an oxidative formamidopyrimidine-dG DNA lesion -dC basepair in the post-insertion site.

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0003676molecular_functionnucleic acid binding
A0003677molecular_functionDNA binding
A0003887molecular_functionDNA-directed DNA polymerase activity
A0004518molecular_functionnuclease activity
A0004527molecular_functionexonuclease activity
A0006139biological_processnucleobase-containing compound metabolic process
A0006260biological_processDNA replication
A0006261biological_processDNA-templated DNA replication
A0006281biological_processDNA repair
A0006302biological_processdouble-strand break repair
A0006974biological_processDNA damage response
A0008408molecular_function3'-5' exonuclease activity
A0016740molecular_functiontransferase activity
A0016779molecular_functionnucleotidyltransferase activity
A0016787molecular_functionhydrolase activity
A0034061molecular_functionDNA polymerase activity
A0046872molecular_functionmetal ion binding
A0071897biological_processDNA biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues2
DetailsBINDING SITE FOR RESIDUE MG A 1877
ChainResidue
AASP653
ATYR654

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 1878
ChainResidue
AHIS682
AARG702
ALYS706
AHOH2049

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 1879
ChainResidue
AHOH2052
AALA300
AARG343
AARG677

Functional Information from PROSITE/UniProt
site_idPS00447
Number of Residues20
DetailsDNA_POLYMERASE_A DNA polymerase family A signature. RrqAKavnFGivYgiSdygL
ChainResidueDetails
AARG702-LEU721

238895

PDB entries from 2025-07-16

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