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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4B8R

Crystal Structure of Thermococcus litoralis ADP-dependent Glucokinase (GK)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004340	molecular_function	glucokinase activity
A	0005737	cellular_component	cytoplasm
A	0005975	biological_process	carbohydrate metabolic process
A	0006006	biological_process	glucose metabolic process
A	0006096	biological_process	glycolytic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
A	0043843	molecular_function	ADP-specific glucokinase activity
A	0046872	molecular_function	metal ion binding
A	0051156	biological_process	glucose 6-phosphate metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GOL A 1468

Chain	Residue
A	ASN233

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 1469

Chain	Residue
A	LYS45
A	TYR46
A	ASP51
A	TRP111
A	ASP114
A	HOH2044
A	HOH2046
A	HOH2081

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 1470

Chain	Residue
A	ALA281
A	TYR282
A	ASN305
A	VAL307
A	GLU308

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 1471

Chain	Residue
A	MET341
A	ASP342
A	GLN362
A	ASP429
A	ARG430
A	GOL1475

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 1472

Chain	Residue
A	TYR354
A	ASN403
A	ARG405
A	PGE1494
A	SO41498
A	HOH2227

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 1473

Chain	Residue
A	ALA379
A	ALA380
A	LYS438
A	ILE439
A	VAL440
A	ILE449
A	HOH2228
A	HOH2272
A	HOH2282

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1474

Chain	Residue
A	GLU102
A	ARG106
A	ARG109
A	PHE420
A	GLU421
A	HOH2068
A	HOH2078

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 1475

Chain	Residue
A	ASP342
A	GLU343
A	GOL1471

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 1476

Chain	Residue
A	VAL159
A	PRO160
A	ALA175
A	ARG220
A	GLU222
A	SO41500
A	HOH2101
A	HOH2283

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1477

Chain	Residue
A	PRO71
A	ARG87
A	LYS93
A	MET95
A	TRP97
A	HOH2053
A	HOH2065

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1478

Chain	Residue
A	ASP260
A	ARG261
A	SER264
A	GLU327
A	HIS329
A	HOH2183
A	HOH2189

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1479

Chain	Residue
A	PHE162
A	GLY164
A	ASP174
A	ILE176
A	ARG221
A	HOH2123
A	HOH2133

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 1480

Chain	Residue
A	SER101
A	GLU102
A	GLU103

site_id	BC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1481

Chain	Residue
A	THR446
A	VAL447
A	GLY448
A	ILE449
A	GLY450
A	HOH2274
A	HOH2285

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 1482

Chain	Residue
A	SER264
A	ASN267
A	ARG271
A	HOH2189
A	HOH2193

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE TRS A 1483

Chain	Residue
A	TYR282
A	ARG286
A	ARG289
A	SER311
A	GLU314
A	PEG1487

site_id	BC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE TRS A 1484

Chain	Residue
A	GLU308
A	HIS352
A	GLY450
A	ASP451
A	GLU279
A	GLY303
A	LEU304
A	ASN305

site_id	BC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE DTT A 1485

Chain	Residue
A	ASN40
A	ASP42
A	GLU96
A	GLY119
A	GLY120
A	ILE124
A	HIS184
A	ILE207

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DTT A 1486

Chain	Residue
A	ARG369
A	GLU421
A	ASN422
A	HOH2018
A	HOH2287

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PEG A 1487

Chain	Residue
A	ALA310
A	GLU314
A	TRS1483

site_id	CC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PEG A 1488

Chain	Residue
A	LYS2
A	ARG8
A	PRO142
A	TYR213
A	TYR218
A	MET219
A	ARG220
A	VAL408
A	GLU411
A	HOH2105

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PEG A 1489

Chain	Residue
A	ARG117
A	ILE118
A	ASN127
A	GLU150
A	LEU151
A	PHE152

site_id	CC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PEG A 1490

Chain	Residue
A	GLU247
A	TYR248
A	ASN285

site_id	CC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PEG A 1491

Chain	Residue
A	ARG271
A	TYR272

site_id	CC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PGE A 1492

Chain	Residue
A	GLU347
A	TYR363
A	GLU461
A	ARG465
A	SO41495
A	HOH2196
A	HOH2288

site_id	CC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PGE A 1493

Chain	Residue
A	ASN270
A	ASN273
A	VAL274
A	LYS275
A	PRO297
A	THR300
A	GLU347
A	HOH2207

site_id	CC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PGE A 1494

Chain	Residue
A	ARG224
A	ARG261
A	GLY328
A	HIS329
A	ILE330
A	GLU412
A	GOL1472
A	HOH2217

site_id	DC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1495

Chain	Residue
A	ASN273
A	LYS275
A	PGE1492
A	HOH2195

site_id	DC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1496

Chain	Residue
A	LYS385
A	ARG390
A	GLN393

site_id	DC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 1497

Chain	Residue
A	ARG117
A	GLU188
A	ARG205
A	LYS444
A	SER445
A	THR446
A	VAL447

site_id	DC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 1498

Chain	Residue
A	ARG224
A	ARG405
A	GOL1472
A	HOH2256
A	HOH2257
A	HOH2290
A	HOH2291

site_id	DC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 A 1499

Chain	Residue
A	ARG134

site_id	DC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 1500

Chain	Residue
A	ARG220
A	ARG221
A	GLU222
A	LYS415
A	GOL1476
A	HOH2122
A	HOH2156
A	HOH2283
A	HOH2284

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	457
Details	Domain: {"description":"ADPK","evidences":[{"source":"HAMAP-Rule","id":"MF_00809","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00809","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00809","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23818958","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4B8S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00809","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23818958","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4B8S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00809","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11286887","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23818958","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1GC5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4B8S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

246333

PDB entries from 2025-12-17

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