4B4G

Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0008879	molecular_function	glucose-1-phosphate thymidylyltransferase activity
A	0009058	biological_process	biosynthetic process
A	0009244	biological_process	lipopolysaccharide core region biosynthetic process
A	0016779	molecular_function	nucleotidyltransferase activity
A	0019305	biological_process	dTDP-rhamnose biosynthetic process
A	0045226	biological_process	extracellular polysaccharide biosynthetic process
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0008879	molecular_function	glucose-1-phosphate thymidylyltransferase activity
B	0009058	biological_process	biosynthetic process
B	0009244	biological_process	lipopolysaccharide core region biosynthetic process
B	0016779	molecular_function	nucleotidyltransferase activity
B	0019305	biological_process	dTDP-rhamnose biosynthetic process
B	0045226	biological_process	extracellular polysaccharide biosynthetic process
B	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0008879	molecular_function	glucose-1-phosphate thymidylyltransferase activity
C	0009058	biological_process	biosynthetic process
C	0009244	biological_process	lipopolysaccharide core region biosynthetic process
C	0016779	molecular_function	nucleotidyltransferase activity
C	0019305	biological_process	dTDP-rhamnose biosynthetic process
C	0045226	biological_process	extracellular polysaccharide biosynthetic process
C	0046872	molecular_function	metal ion binding
D	0000166	molecular_function	nucleotide binding
D	0008879	molecular_function	glucose-1-phosphate thymidylyltransferase activity
D	0009058	biological_process	biosynthetic process
D	0009244	biological_process	lipopolysaccharide core region biosynthetic process
D	0016779	molecular_function	nucleotidyltransferase activity
D	0019305	biological_process	dTDP-rhamnose biosynthetic process
D	0045226	biological_process	extracellular polysaccharide biosynthetic process
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE KKT A 400

Chain	Residue
A	LEU45
A	HOH2022
A	HOH2024
A	HOH2044
A	TYR113
A	GLY115
A	PHE118
A	ARG219
A	VAL250
A	ALA251
A	GLU255
A	ILE256

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1294

Chain	Residue
A	HIS116
A	GLY218
A	GLY220

---

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE KKT B 400

Chain	Residue
B	SER41
B	THR42
B	TYR113
B	TYR114
B	GLY115
B	PHE118
B	ARG219
B	VAL250
B	ALA251
B	GLU255
B	HOH2016
B	HOH2018
B	HOH2040

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 1294

Chain	Residue
B	HIS116
B	GLY220
B	HOH2017

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MES B 1295

Chain	Residue
B	PHE150
B	GLY154
B	LYS155
B	ALA156
B	SER213
B	VAL214
B	ILE216

---

site_id	AC6
Number of Residues	15
Details	BINDING SITE FOR RESIDUE KKT C 400

Chain	Residue
C	THR42
C	LEU45
C	TYR113
C	TYR114
C	GLY115
C	PHE118
C	HIS119
C	ARG219
C	VAL250
C	ALA251
C	GLU255
C	ILE256
C	HOH2016
C	HOH2017
C	HOH2030

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MES C 1294

Chain	Residue
C	GLY154
C	ALA156
C	SER213
C	VAL214
C	ILE216

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 1295

Chain	Residue
C	HIS116
C	GLY220

---

site_id	AC9
Number of Residues	15
Details	BINDING SITE FOR RESIDUE KKT D 400

Chain	Residue
D	SER41
D	THR42
D	LEU45
D	TYR113
D	GLY115
D	PHE118
D	HIS119
D	ARG219
D	VAL250
D	ALA251
D	GLU255
D	ARG259
D	HOH2011
D	HOH2013
D	HOH2024

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL D 1294

Chain	Residue
D	HIS116
D	GLY220

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