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4B3Z

Structure of the human collapsin response mediator protein-1, a lung cancer suppressor

Functional Information from GO Data
ChainGOidnamespacecontents
A0004157molecular_functiondihydropyrimidinase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005813cellular_componentcentrosome
A0005819cellular_componentspindle
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0006139biological_processnucleobase-containing compound metabolic process
A0006208biological_processpyrimidine nucleobase catabolic process
A0007399biological_processnervous system development
A0010977biological_processnegative regulation of neuron projection development
A0016787molecular_functionhydrolase activity
A0016810molecular_functionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
A0016812molecular_functionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A0030426cellular_componentgrowth cone
A0030496cellular_componentmidbody
A0031005molecular_functionfilamin binding
A0042802molecular_functionidentical protein binding
A0042995cellular_componentcell projection
A0043204cellular_componentperikaryon
B0004157molecular_functiondihydropyrimidinase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005813cellular_componentcentrosome
B0005819cellular_componentspindle
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0006139biological_processnucleobase-containing compound metabolic process
B0006208biological_processpyrimidine nucleobase catabolic process
B0007399biological_processnervous system development
B0010977biological_processnegative regulation of neuron projection development
B0016787molecular_functionhydrolase activity
B0016810molecular_functionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
B0016812molecular_functionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B0030426cellular_componentgrowth cone
B0030496cellular_componentmidbody
B0031005molecular_functionfilamin binding
B0042802molecular_functionidentical protein binding
B0042995cellular_componentcell projection
B0043204cellular_componentperikaryon
C0004157molecular_functiondihydropyrimidinase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005813cellular_componentcentrosome
C0005819cellular_componentspindle
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0006139biological_processnucleobase-containing compound metabolic process
C0006208biological_processpyrimidine nucleobase catabolic process
C0007399biological_processnervous system development
C0010977biological_processnegative regulation of neuron projection development
C0016787molecular_functionhydrolase activity
C0016810molecular_functionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
C0016812molecular_functionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C0030426cellular_componentgrowth cone
C0030496cellular_componentmidbody
C0031005molecular_functionfilamin binding
C0042802molecular_functionidentical protein binding
C0042995cellular_componentcell projection
C0043204cellular_componentperikaryon
D0004157molecular_functiondihydropyrimidinase activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005813cellular_componentcentrosome
D0005819cellular_componentspindle
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0006139biological_processnucleobase-containing compound metabolic process
D0006208biological_processpyrimidine nucleobase catabolic process
D0007399biological_processnervous system development
D0010977biological_processnegative regulation of neuron projection development
D0016787molecular_functionhydrolase activity
D0016810molecular_functionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
D0016812molecular_functionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D0030426cellular_componentgrowth cone
D0030496cellular_componentmidbody
D0031005molecular_functionfilamin binding
D0042802molecular_functionidentical protein binding
D0042995cellular_componentcell projection
D0043204cellular_componentperikaryon
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q62950
ChainResidueDetails
ASER8
ASER521
BSER8
BSER521
CSER8
CSER521
DSER8
DSER521

site_idSWS_FT_FI2
Number of Residues8
DetailsMOD_RES: Phosphothreonine; by AURKA => ECO:0000269|PubMed:19799413
ChainResidueDetails
ATHR101
ATHR102
BTHR101
BTHR102
CTHR101
CTHR102
DTHR101
DTHR102

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: 3'-nitrotyrosine => ECO:0000250|UniProtKB:P97427
ChainResidueDetails
ATYR316
BTYR316
CTYR316
DTYR316

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P97427
ChainResidueDetails
ATYR504
BTYR504
CTYR504
DTYR504

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P97427
ChainResidueDetails
ATHR509
BTHR509
CTHR509
DTHR509

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000305|PubMed:25358863
ChainResidueDetails
ASER522
BSER522
CSER522
DSER522

site_idSWS_FT_FI7
Number of Residues12
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P97427
ChainResidueDetails
ASER537
DSER537
DSER540
DSER542
ASER540
ASER542
BSER537
BSER540
BSER542
CSER537
CSER540
CSER542

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PDB entries from 2024-10-09

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