4B3A

Tetracycline repressor class D mutant H100A in complex with tetracycline

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0046677	biological_process	response to antibiotic
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE TAC A 222

Chain	Residue
A	LEU60
A	SER138
A	LEU170
A	LEU174
A	MET177
A	MG1212
A	HOH2070
A	HOH2071
A	HOH2072
A	HOH2078
A	HOH2130
A	HIS64
A	SER67
A	ASN82
A	PHE86
A	ARG104
A	PRO105
A	VAL113
A	GLN116

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 1209

Chain	Residue
A	SER2
A	ARG3
A	SER74
A	SER77

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site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 1210

Chain	Residue
A	ARG3
A	LEU4
A	GLN76
A	ARG80
A	HOH2119

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site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 1211

Chain	Residue
A	THR27

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site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 1212

Chain	Residue
A	TAC222
A	HOH2070
A	HOH2071
A	HOH2072
A	HOH2130

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Functional Information from PROSITE/UniProt

site_id	PS01081
Number of Residues	32
Details	HTH_TETR_1 TetR-type HTH domain signature. GIdglTTrkLaqklgIEqPtLYwHVkNKralL

Chain	Residue	Details
A	GLY21-LEU52

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	19
Details	DNA_BIND: H-T-H motif => ECO:0000255|PROSITE-ProRule:PRU00335

Chain	Residue	Details
A	THR26-VAL45

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:8153629, ECO:0007744|PDB:2TRT

Chain	Residue	Details
A	HIS64
A	ASN82
A	ALA100

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