4B2Y
Probing the active center of catalase-phenol oxidase from Scytalidium thermophilum
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004096 | molecular_function | catalase activity |
| A | 0004601 | molecular_function | peroxidase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0020037 | molecular_function | heme binding |
| A | 0042744 | biological_process | hydrogen peroxide catabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| B | 0004096 | molecular_function | catalase activity |
| B | 0004601 | molecular_function | peroxidase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006979 | biological_process | response to oxidative stress |
| B | 0020037 | molecular_function | heme binding |
| B | 0042744 | biological_process | hydrogen peroxide catabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0098869 | biological_process | cellular oxidant detoxification |
| C | 0004096 | molecular_function | catalase activity |
| C | 0004601 | molecular_function | peroxidase activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0006979 | biological_process | response to oxidative stress |
| C | 0020037 | molecular_function | heme binding |
| C | 0042744 | biological_process | hydrogen peroxide catabolic process |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0098869 | biological_process | cellular oxidant detoxification |
| D | 0004096 | molecular_function | catalase activity |
| D | 0004601 | molecular_function | peroxidase activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0006979 | biological_process | response to oxidative stress |
| D | 0020037 | molecular_function | heme binding |
| D | 0042744 | biological_process | hydrogen peroxide catabolic process |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE HEM A 754 |
| Chain | Residue |
| A | ARG79 |
| A | PHE168 |
| A | VAL228 |
| A | HIS229 |
| A | PHE345 |
| A | LEU361 |
| A | ARG365 |
| A | SER368 |
| A | TYR369 |
| A | THR372 |
| A | GLN373 |
| A | VAL81 |
| A | ARG376 |
| A | HOH2104 |
| A | HOH2107 |
| A | HOH2153 |
| A | HOH2350 |
| C | ASP72 |
| A | HIS82 |
| A | ARG119 |
| A | GLY138 |
| A | VAL153 |
| A | GLY154 |
| A | ASN155 |
| A | PHE160 |
| site_id | AC2 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE HEM B 754 |
| Chain | Residue |
| B | ARG79 |
| B | VAL81 |
| B | HIS82 |
| B | ARG119 |
| B | GLY138 |
| B | VAL153 |
| B | GLY154 |
| B | ASN155 |
| B | PHE160 |
| B | PHE168 |
| B | VAL228 |
| B | HIS229 |
| B | PHE345 |
| B | LEU361 |
| B | ARG365 |
| B | SER368 |
| B | TYR369 |
| B | THR372 |
| B | GLN373 |
| B | ARG376 |
| B | HOH2098 |
| B | HOH2101 |
| B | HOH2133 |
| B | HOH2306 |
| D | ASP72 |
| site_id | AC3 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE HEM C 754 |
| Chain | Residue |
| A | ASP72 |
| C | ARG79 |
| C | VAL81 |
| C | HIS82 |
| C | ARG119 |
| C | GLY138 |
| C | PHE139 |
| C | VAL153 |
| C | GLY154 |
| C | ASN155 |
| C | PHE160 |
| C | PHE168 |
| C | HIS229 |
| C | PHE345 |
| C | LEU361 |
| C | ARG365 |
| C | SER368 |
| C | TYR369 |
| C | THR372 |
| C | GLN373 |
| C | ARG376 |
| C | HOH2035 |
| C | HOH2038 |
| C | HOH2073 |
| C | HOH2225 |
| site_id | AC4 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE HEM D 754 |
| Chain | Residue |
| B | ASP72 |
| D | ARG79 |
| D | VAL81 |
| D | HIS82 |
| D | ARG119 |
| D | GLY138 |
| D | VAL153 |
| D | GLY154 |
| D | ASN155 |
| D | PHE160 |
| D | PHE168 |
| D | HIS229 |
| D | PHE345 |
| D | LEU361 |
| D | ARG365 |
| D | SER368 |
| D | TYR369 |
| D | THR372 |
| D | GLN373 |
| D | ARG376 |
| D | HOH2031 |
| D | HOH2033 |
| D | HOH2066 |
| D | HOH2204 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 1699 |
| Chain | Residue |
| A | HIS190 |
| A | SER192 |
| A | HOH2222 |
| A | HOH2582 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1700 |
| Chain | Residue |
| A | HOH2377 |
| A | HOH2378 |
| A | HOH2583 |
| A | HOH2584 |
| A | HOH2585 |
| B | HOH2334 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA B 1699 |
| Chain | Residue |
| A | HOH2425 |
| B | ARG178 |
| B | HIS190 |
| B | SER192 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA C 1699 |
| Chain | Residue |
| C | HIS190 |
| C | SER192 |
| C | HOH2124 |
| C | HOH2128 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CA C 1700 |
| Chain | Residue |
| C | SER255 |
| C | HOH2142 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA D 1699 |
| Chain | Residue |
| D | HIS190 |
| D | ASP191 |
| D | SER192 |
| D | HOH2334 |
Functional Information from PROSITE/UniProt
| site_id | PS00437 |
| Number of Residues | 9 |
| Details | CATALASE_1 Catalase proximal heme-ligand signature. RLFSYlDTQ |
| Chain | Residue | Details |
| A | ARG365-GLN373 |
| site_id | PS00438 |
| Number of Residues | 17 |
| Details | CATALASE_2 Catalase proximal active site signature. FdHervpERavHarGAG |
| Chain | Residue | Details |
| A | PHE71-GLY87 |
| site_id | PS00674 |
| Number of Residues | 20 |
| Details | AAA AAA-protein family signature. VgILaTTSessaLDqAAqlR |
| Chain | Residue | Details |
| A | VAL552-ARG571 |
