4B1T
Structure of the factor Xa-like trypsin variant triple-Ala (TA) in complex with eglin C
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004175 | molecular_function | endopeptidase activity |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006508 | biological_process | proteolysis |
| A | 0007586 | biological_process | digestion |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0097180 | cellular_component | serine protease inhibitor complex |
| A | 0097655 | molecular_function | serpin family protein binding |
| B | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| B | 0009611 | biological_process | response to wounding |
| B | 0030414 | molecular_function | peptidase inhibitor activity |
| C | 0004175 | molecular_function | endopeptidase activity |
| C | 0004252 | molecular_function | serine-type endopeptidase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005615 | cellular_component | extracellular space |
| C | 0006508 | biological_process | proteolysis |
| C | 0007586 | biological_process | digestion |
| C | 0008233 | molecular_function | peptidase activity |
| C | 0008236 | molecular_function | serine-type peptidase activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0097180 | cellular_component | serine protease inhibitor complex |
| C | 0097655 | molecular_function | serpin family protein binding |
| D | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| D | 0009611 | biological_process | response to wounding |
| D | 0030414 | molecular_function | peptidase inhibitor activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1246 |
| Chain | Residue |
| A | GLU70 |
| A | ASN72 |
| A | VAL75 |
| A | GLU80 |
| A | HOH2039 |
| A | HOH2040 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 1247 |
| Chain | Residue |
| A | HIS40 |
| A | ARG66 |
| A | ILE73 |
| A | ASN74 |
| A | HOH2020 |
| A | HOH2045 |
| A | ASN34 |
| A | GLY38 |
| A | TYR39 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 1248 |
| Chain | Residue |
| A | ASN72 |
| A | VAL75 |
| A | ASP153 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 1249 |
| Chain | Residue |
| A | TYR20 |
| A | CYS22 |
| A | THR26 |
| A | LYS159 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 1071 |
| Chain | Residue |
| B | TYR35 |
| B | LEU37 |
| B | ARG51 |
| B | ARG53 |
| B | HOH2020 |
| B | HOH2022 |
| B | HOH2033 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 1072 |
| Chain | Residue |
| A | HOH2094 |
| A | HOH2095 |
| B | GLU39 |
| B | GLY40 |
| B | PHE55 |
| B | HIS65 |
| B | HOH2034 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 1073 |
| Chain | Residue |
| B | LEU7 |
| B | TYR49 |
| B | HOH2005 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 1074 |
| Chain | Residue |
| B | PHE3 |
| B | THR26 |
| B | PRO30 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA C 1246 |
| Chain | Residue |
| C | GLU70 |
| C | ASN72 |
| C | VAL75 |
| C | GLU80 |
| C | HOH2039 |
| C | HOH2040 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL C 1247 |
| Chain | Residue |
| C | ILE16 |
| C | GLY18 |
| C | GLY19 |
| C | THR144 |
| C | LYS156 |
| C | HOH2002 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO C 1248 |
| Chain | Residue |
| C | ASN34 |
| C | GLY38 |
| C | TYR39 |
| C | HIS40 |
| C | ILE73 |
| site_id | BC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL D 1071 |
| Chain | Residue |
| C | GLN192 |
| D | VAL52 |
| D | ARG53 |
| D | HIS68 |
| D | GLY70 |
| D | HOH2013 |
| D | HOH2020 |
| D | HOH2021 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL D 1072 |
| Chain | Residue |
| C | HOH2095 |
| D | GLU39 |
| D | GLY40 |
| D | HIS65 |
| D | HOH2018 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL D 1073 |
| Chain | Residue |
| D | ARG51 |
| D | ARG53 |
| D | HOH2022 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 440 |
| Details | Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Active site: {"description":"Charge relay system"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Site: {"description":"Reactive bond"} |
| Chain | Residue | Details |
