4B1C

New Aminoimidazoles as BACE-1 Inhibitors: From Rational Design to Ab- lowering in Brain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004190	molecular_function	aspartic-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS A 1503

Chain	Residue
A	GLY230
A	THR231
A	THR232
A	HOH2175

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site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 1B1 A 1504

Chain	Residue
A	PHE108
A	TRP115
A	ILE118
A	ASP228
A	SER229
A	GLY230
A	THR231
A	ALA335
A	HOH2259
A	SER10
A	GLN12
A	GLY13
A	ASP32
A	TYR71

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Functional Information from PROSITE/UniProt

site_id	PS00141
Number of Residues	12
Details	ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ILVDTGSSNFAV

Chain	Residue	Details
A	ILE29-VAL40

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10094

Chain	Residue	Details
A	ASP32
A	GLU242

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site_id	SWS_FT_FI2
Number of Residues	7
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:17425515, ECO:0000269|PubMed:19011241

Chain	Residue	Details
A	LYS65
A	ASP228
A	THR232
A	LYS238
A	SER252
A	SER253
A	GLY260

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site_id	SWS_FT_FI3
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN92
A	ASN111
A	ILE176
A	ARG307

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