4B1B
Crystal structure of Plasmodium falciparum oxidised Thioredoxin Reductase at 2.9 angstrom
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| A | 0045454 | biological_process | cell redox homeostasis |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| B | 0045454 | biological_process | cell redox homeostasis |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 31 |
| Details | BINDING SITE FOR RESIDUE FAD A 1506 |
| Chain | Residue |
| A | GLY48 |
| A | THR87 |
| A | CYS88 |
| A | GLY92 |
| A | CYS93 |
| A | LYS96 |
| A | GLY159 |
| A | LEU160 |
| A | ALA161 |
| A | ALA191 |
| A | THR192 |
| A | GLY49 |
| A | GLY193 |
| A | TYR232 |
| A | ASP319 |
| A | LEU323 |
| A | GLY356 |
| A | ASP357 |
| A | GLU364 |
| A | LEU365 |
| A | ALA366 |
| A | PRO367 |
| A | GLY50 |
| A | HOH2001 |
| A | HOH2002 |
| A | PRO51 |
| A | GLY52 |
| A | ASP71 |
| A | TYR72 |
| A | VAL73 |
| A | GLY86 |
| site_id | AC2 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE FAD B 1506 |
| Chain | Residue |
| B | GLY48 |
| B | GLY49 |
| B | GLY50 |
| B | PRO51 |
| B | GLY52 |
| B | ASP71 |
| B | TYR72 |
| B | VAL73 |
| B | GLY86 |
| B | THR87 |
| B | CYS88 |
| B | VAL91 |
| B | GLY92 |
| B | CYS93 |
| B | LYS96 |
| B | LYS97 |
| B | GLY159 |
| B | LEU160 |
| B | ALA161 |
| B | ALA191 |
| B | THR192 |
| B | GLY193 |
| B | TYR232 |
| B | ARG316 |
| B | ASP319 |
| B | LEU323 |
| B | GLY356 |
| B | ASP357 |
| B | GLU364 |
| B | LEU365 |
| B | ALA366 |
| B | PRO367 |
| B | HOH2001 |
Functional Information from PROSITE/UniProt
| site_id | PS00076 |
| Number of Residues | 11 |
| Details | PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCVnvGCVP |
| Chain | Residue | Details |
| A | GLY85-PRO95 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000269|PubMed:9368022 |
| Chain | Residue | Details |
| A | HIS509 | |
| B | HIS509 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | BINDING: in other chain => ECO:0000269|PubMed:22889878, ECO:0000269|PubMed:23845423, ECO:0007744|PDB:4B1B, ECO:0007744|PDB:4J56, ECO:0007744|PDB:4J57 |
| Chain | Residue | Details |
| A | PRO51 | |
| B | THR87 | |
| B | GLY92 | |
| B | ALA161 | |
| B | ASP357 | |
| B | GLU364 | |
| A | ASP71 | |
| A | THR87 | |
| A | GLY92 | |
| A | ALA161 | |
| A | ASP357 | |
| A | GLU364 | |
| B | PRO51 | |
| B | ASP71 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23845423, ECO:0007744|PDB:4J56, ECO:0007744|PDB:4J57 |
| Chain | Residue | Details |
| A | HIS509 | |
| B | HIS509 |
