4B17

Crystal structure of C2498 2'-O-ribose methyltransferase RlmM from Escherichia coli in complex with S-adenosylmethionine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0006364	biological_process	rRNA processing
A	0008168	molecular_function	methyltransferase activity
A	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
A	0016740	molecular_function	transferase activity
A	0031167	biological_process	rRNA methylation
A	0032259	biological_process	methylation
A	0070677	molecular_function	rRNA (cytosine-2'-O-)-methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1361

Chain	Residue
A	GLU112
A	SER113
A	GLU115
A	LEU116
A	PRO155

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 1362

Chain	Residue
A	PHE171
A	ARG177
A	HIS197

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1363

Chain	Residue
A	PRO308
A	MET309
A	LYS310
A	HOH2080
A	LYS281

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1364

Chain	Residue
A	ARG34
A	GLU259
A	ASP260
A	LYS263

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1365

Chain	Residue
A	LYS114
A	TYR172
A	MET173
A	HOH2048

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1366

Chain	Residue
A	PHE196
A	HIS197
A	ILE200
A	ALA202
A	TRP205

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1367

Chain	Residue
A	LYS23
A	SER63
A	ILE336
A	HOH2022

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 1368

Chain	Residue
A	ARG85
A	ASN211
A	ASN233

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 1369

Chain	Residue
A	ARG57
A	ASN166

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 1370

Chain	Residue
A	PHE264
A	THR267
A	ARG268

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 1371

Chain	Residue
A	ASP22
A	TYR313
A	GLU314

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1372

Chain	Residue
A	ALA138
A	ASN139
A	TYR140

---

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 1373

Chain	Residue
A	LYS118
A	LYS122

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1374

Chain	Residue
A	TRP214
A	ARG268
A	ASN270

---

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1375

Chain	Residue
A	VAL96
A	TYR164
A	HOH2033

---

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 1359

Chain	Residue
A	GLU15
A	LYS311
A	ARG312
A	TYR313
A	GLU314

---

site_id	BC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1360

Chain	Residue
A	ARG34
A	VAL35
A	LYS36
A	TYR41
A	VAL42
A	ILE43
A	HOH2016

---

site_id	BC9
Number of Residues	14
Details	BINDING SITE FOR RESIDUE SAM A 1358

Chain	Residue
A	ASN38
A	SER188
A	GLY219
A	ALA220
A	CYS221
A	PRO222
A	GLY223
A	GLY224
A	TRP225
A	ASP240
A	ASP260
A	GLY261
A	PHE262
A	ASP277

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"22923526","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22923526","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {}

Chain

Residue

Details

---