4B14
Plasmodium vivax N-myristoyltransferase with a bound benzofuran inhibitor (compound 26)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004379 | molecular_function | glycylpeptide N-tetradecanoyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006499 | biological_process | N-terminal protein myristoylation |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0018008 | biological_process | N-terminal peptidyl-glycine N-myristoylation |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004379 | molecular_function | glycylpeptide N-tetradecanoyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006499 | biological_process | N-terminal protein myristoylation |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0018008 | biological_process | N-terminal peptidyl-glycine N-myristoylation |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0004379 | molecular_function | glycylpeptide N-tetradecanoyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006499 | biological_process | N-terminal protein myristoylation |
| C | 0016746 | molecular_function | acyltransferase activity |
| C | 0018008 | biological_process | N-terminal peptidyl-glycine N-myristoylation |
| C | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS A 999 |
| Chain | Residue |
| A | GLU159 |
| A | PHE281 |
| A | TRP289 |
| A | LEU409 |
| A | HOH2360 |
| site_id | AC2 |
| Number of Residues | 38 |
| Details | BINDING SITE FOR RESIDUE NHW A 1411 |
| Chain | Residue |
| A | ASN94 |
| A | TYR95 |
| A | VAL96 |
| A | ASN161 |
| A | PHE162 |
| A | LEU163 |
| A | CYS164 |
| A | VAL165 |
| A | ARG170 |
| A | SER171 |
| A | LYS172 |
| A | ARG173 |
| A | LEU174 |
| A | ALA175 |
| A | PRO176 |
| A | THR183 |
| A | ILE186 |
| A | TRP192 |
| A | GLN193 |
| A | ALA194 |
| A | TYR196 |
| A | THR197 |
| A | LEU202 |
| A | TYR393 |
| A | MG1413 |
| A | HOH2003 |
| A | HOH2214 |
| A | HOH2221 |
| A | HOH2409 |
| A | HOH2410 |
| A | HOH2411 |
| A | HOH2412 |
| A | HOH2413 |
| A | HOH2414 |
| A | TYR28 |
| A | LYS29 |
| A | PHE30 |
| A | TRP31 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE 4XB A 1001 |
| Chain | Residue |
| A | VAL96 |
| A | GLU97 |
| A | ASP98 |
| A | PHE103 |
| A | PHE105 |
| A | TYR107 |
| A | TYR211 |
| A | HIS213 |
| A | PHE226 |
| A | TYR315 |
| A | LEU317 |
| A | SER319 |
| A | TYR334 |
| A | ASN365 |
| A | LEU367 |
| A | LEU388 |
| A | LEU410 |
| A | HOH2356 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS B 999 |
| Chain | Residue |
| B | GLU159 |
| B | PHE281 |
| B | TRP289 |
| B | HOH2330 |
| site_id | AC5 |
| Number of Residues | 40 |
| Details | BINDING SITE FOR RESIDUE NHW B 1411 |
| Chain | Residue |
| B | HOH2378 |
| B | HOH2379 |
| B | HOH2380 |
| B | HOH2381 |
| B | HOH2382 |
| B | HOH2383 |
| B | MET26 |
| B | TYR28 |
| B | LYS29 |
| B | PHE30 |
| B | TRP31 |
| B | ASN94 |
| B | TYR95 |
| B | VAL96 |
| B | ASN161 |
| B | PHE162 |
| B | LEU163 |
| B | CYS164 |
| B | VAL165 |
| B | ARG170 |
| B | SER171 |
| B | LYS172 |
| B | ARG173 |
| B | LEU174 |
| B | ALA175 |
| B | PRO176 |
| B | THR183 |
| B | ILE186 |
| B | ASN187 |
| B | TRP192 |
| B | GLN193 |
| B | TYR196 |
| B | THR197 |
| B | LEU202 |
| B | TYR393 |
| B | MG1414 |
| B | HOH2002 |
| B | HOH2176 |
| B | HOH2180 |
| B | HOH2181 |
| site_id | AC6 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE 4XB B 1001 |
| Chain | Residue |
| B | VAL96 |
| B | GLU97 |
| B | ASP98 |
| B | PHE103 |
| B | PHE105 |
| B | TYR107 |
| B | TYR211 |
| B | HIS213 |
| B | PHE226 |
| B | TYR315 |
| B | SER319 |
| B | TYR334 |
| B | LEU367 |
| B | LEU388 |
| B | LEU410 |
| B | HOH2216 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS C 999 |
| Chain | Residue |
| C | GLU159 |
| C | PHE281 |
| C | TRP289 |
| C | HOH2291 |
| site_id | AC8 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE NHW C 1411 |
| Chain | Residue |
| C | TYR28 |
| C | LYS29 |
| C | PHE30 |
| C | TRP31 |
| C | ASN94 |
| C | TYR95 |
| C | VAL96 |
| C | ASN161 |
| C | PHE162 |
| C | LEU163 |
| C | CYS164 |
| C | VAL165 |
| C | ARG170 |
| C | SER171 |
| C | LYS172 |
| C | ARG173 |
| C | LEU174 |
| C | ALA175 |
| C | PRO176 |
| C | THR183 |
| C | ILE186 |
| C | TRP192 |
| C | GLN193 |
| C | ALA194 |
| C | TYR196 |
| C | THR197 |
| C | LEU202 |
| C | TYR393 |
| C | MG1413 |
| C | HOH2003 |
| C | HOH2163 |
| C | HOH2170 |
| C | HOH2336 |
| C | HOH2338 |
| site_id | AC9 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE 4XB C 1001 |
| Chain | Residue |
| C | VAL96 |
| C | GLU97 |
| C | ASP98 |
| C | PHE103 |
| C | PHE105 |
| C | TYR107 |
| C | TYR211 |
| C | HIS213 |
| C | PHE226 |
| C | TYR315 |
| C | SER319 |
| C | TYR334 |
| C | LEU367 |
| C | LEU388 |
| C | LEU410 |
| C | HOH2181 |
| C | HOH2287 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1412 |
| Chain | Residue |
| A | ARG210 |
| A | LYS373 |
| A | HOH2243 |
| B | ARG210 |
| B | LYS373 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 1413 |
| Chain | Residue |
| B | LYS180 |
| B | THR247 |
| B | LEU248 |
| B | ARG358 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL C 1412 |
| Chain | Residue |
| C | LYS180 |
| C | THR247 |
| C | LEU248 |
| C | ARG358 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 1412 |
| Chain | Residue |
| A | LYS180 |
| A | THR247 |
| A | LEU248 |
| A | ARG358 |
| A | HOH2080 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 1414 |
| Chain | Residue |
| B | LEU169 |
| B | SER171 |
| B | LYS172 |
| B | ARG173 |
| B | LEU174 |
| B | NHW1411 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG C 1413 |
| Chain | Residue |
| C | LEU169 |
| C | SER171 |
| C | LYS172 |
| C | ARG173 |
| C | LEU174 |
| C | NHW1411 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 1413 |
| Chain | Residue |
| A | LEU169 |
| A | SER171 |
| A | LYS172 |
| A | ARG173 |
| A | LEU174 |
| A | NHW1411 |
Functional Information from PROSITE/UniProt
