4AYW

STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10 (PLATE FORM)

Replaces:  4AA3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0016020	cellular_component	membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0055085	biological_process	transmembrane transport
A	0140359	molecular_function	ABC-type transporter activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ANP A 1719

Chain	Residue
A	ASP264
A	TYR501
A	SER529
A	GLY530
A	GLY532
A	LYS533
A	SER534
A	THR535

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE LMT A 1724

Chain	Residue
A	LEU419
A	ASP677
A	ARG678
A	ASP681
A	LYS416

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE Y01 A 1730

Chain	Residue
A	ARG170
A	ARG213
A	ALA227
A	ALA230
A	TYR234
A	LEU235
A	ARG389
A	PHE393
A	GLY397
A	LEU404

---

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKQRIAIARAL

Chain	Residue	Details
A	LEU634-LEU648

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	130
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"23716676","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4AYT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	35
Details	Topological domain: {"description":"Mitochondrial intermembrane","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	108
Details	Topological domain: {"description":"Mitochondrial matrix","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	286
Details	Domain: {"description":"ABC transmembrane type-1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37041204","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7Y48","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23716676","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4AYT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AYX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23716676","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4AYT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AYW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AYX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23716676","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4AYT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AYW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23716676","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4AYT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AYX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Modified residue: {"description":"S-glutathionyl cysteine","evidences":[{"source":"UniProtKB","id":"Q9JI39","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---