4AXM

TRIAZINE CATHEPSIN INHIBITOR COMPLEX

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity
B	0006508	biological_process	proteolysis
B	0008234	molecular_function	cysteine-type peptidase activity
F	0006508	biological_process	proteolysis
F	0008234	molecular_function	cysteine-type peptidase activity
I	0006508	biological_process	proteolysis
I	0008234	molecular_function	cysteine-type peptidase activity
L	0006508	biological_process	proteolysis
L	0008234	molecular_function	cysteine-type peptidase activity
O	0006508	biological_process	proteolysis
O	0008234	molecular_function	cysteine-type peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL A 1221

Chain	Residue
A	ASN18
A	GLY20

---

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE V65 A 1222

Chain	Residue
A	LEU69
A	ALA135
A	ASP162
A	HIS163
A	GLY164
I	ARG206
A	GLN19
A	GLY23
A	SER24
A	CYS25
A	GLY61
A	GLU63
A	GLY68

---

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GOL F 1221

Chain	Residue
F	ASN18

---

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE V65 B 1222

Chain	Residue
B	GLN19
B	GLY23
B	SER24
B	CYS25
B	ASN66
B	GLY67
B	GLY68
B	LEU69
F	ARG206

---

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GOL I 1221

Chain	Residue
I	ASN18

---

site_id	AC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE V65 F 1222

Chain	Residue
F	GLN19
F	GLY23
F	CYS25
F	GLU63
F	CYS65
F	ASN66
F	GLY67
F	GLY68
F	LEU69
F	MET161
F	ASP162
L	ARG206

---

site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GOL L 1221

Chain	Residue
L	ASN18

---

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE V65 I 1222

Chain	Residue
I	GLN19
I	GLY23
I	SER24
I	CYS25
I	CYS65
I	GLY67
I	GLY68
I	ASP162
O	ARG206

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL O 1221

Chain	Residue
O	GLY20
O	LEU144

---

site_id	BC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE V65 L 1222

Chain	Residue
A	ARG206
L	GLN19
L	GLY23
L	CYS25
L	ASN66
L	GLY68
L	LEU69
L	ALA135
L	ASP162

---

site_id	BC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE V65 O 1222

Chain	Residue
O	GLY23
O	CYS25
O	ASN66
O	GLY67
O	GLY68
O	LEU69
O	ALA135
O	MET161
O	ASP162
O	HIS163
O	GLY164

---

Functional Information from PROSITE/UniProt

site_id	PS00139
Number of Residues	12
Details	THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGqCGSCWAfSA

Chain	Residue	Details
A	GLN19-ALA30

---

site_id	PS00639
Number of Residues	11
Details	THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. MDHGVLVVGYG

Chain	Residue	Details
A	MET161-GLY171

---

site_id	PS00640
Number of Residues	20
Details	THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWLvKNSWgeeWGmgGYVkM

Chain	Residue	Details
A	TYR182-MET201

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Active site: {"evidences":[{"source":"PubMed","id":"9468501","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Active site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	66
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37990007","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HFV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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