4AXM
TRIAZINE CATHEPSIN INHIBITOR COMPLEX
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006508 | biological_process | proteolysis |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008234 | molecular_function | cysteine-type peptidase activity |
| F | 0006508 | biological_process | proteolysis |
| F | 0008234 | molecular_function | cysteine-type peptidase activity |
| I | 0006508 | biological_process | proteolysis |
| I | 0008234 | molecular_function | cysteine-type peptidase activity |
| L | 0006508 | biological_process | proteolysis |
| L | 0008234 | molecular_function | cysteine-type peptidase activity |
| O | 0006508 | biological_process | proteolysis |
| O | 0008234 | molecular_function | cysteine-type peptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL A 1221 |
| Chain | Residue |
| A | ASN18 |
| A | GLY20 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE V65 A 1222 |
| Chain | Residue |
| A | LEU69 |
| A | ALA135 |
| A | ASP162 |
| A | HIS163 |
| A | GLY164 |
| I | ARG206 |
| A | GLN19 |
| A | GLY23 |
| A | SER24 |
| A | CYS25 |
| A | GLY61 |
| A | GLU63 |
| A | GLY68 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE GOL F 1221 |
| Chain | Residue |
| F | ASN18 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE V65 B 1222 |
| Chain | Residue |
| B | GLN19 |
| B | GLY23 |
| B | SER24 |
| B | CYS25 |
| B | ASN66 |
| B | GLY67 |
| B | GLY68 |
| B | LEU69 |
| F | ARG206 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE GOL I 1221 |
| Chain | Residue |
| I | ASN18 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE V65 F 1222 |
| Chain | Residue |
| F | GLN19 |
| F | GLY23 |
| F | CYS25 |
| F | GLU63 |
| F | CYS65 |
| F | ASN66 |
| F | GLY67 |
| F | GLY68 |
| F | LEU69 |
| F | MET161 |
| F | ASP162 |
| L | ARG206 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE GOL L 1221 |
| Chain | Residue |
| L | ASN18 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE V65 I 1222 |
| Chain | Residue |
| I | GLN19 |
| I | GLY23 |
| I | SER24 |
| I | CYS25 |
| I | CYS65 |
| I | GLY67 |
| I | GLY68 |
| I | ASP162 |
| O | ARG206 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL O 1221 |
| Chain | Residue |
| O | GLY20 |
| O | LEU144 |
| site_id | BC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE V65 L 1222 |
| Chain | Residue |
| A | ARG206 |
| L | GLN19 |
| L | GLY23 |
| L | CYS25 |
| L | ASN66 |
| L | GLY68 |
| L | LEU69 |
| L | ALA135 |
| L | ASP162 |
| site_id | BC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE V65 O 1222 |
| Chain | Residue |
| O | GLY23 |
| O | CYS25 |
| O | ASN66 |
| O | GLY67 |
| O | GLY68 |
| O | LEU69 |
| O | ALA135 |
| O | MET161 |
| O | ASP162 |
| O | HIS163 |
| O | GLY164 |
Functional Information from PROSITE/UniProt
| site_id | PS00139 |
| Number of Residues | 12 |
| Details | THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGqCGSCWAfSA |
| Chain | Residue | Details |
| A | GLN19-ALA30 |
| site_id | PS00639 |
| Number of Residues | 11 |
| Details | THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. MDHGVLVVGYG |
| Chain | Residue | Details |
| A | MET161-GLY171 |
| site_id | PS00640 |
| Number of Residues | 20 |
| Details | THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWLvKNSWgeeWGmgGYVkM |
| Chain | Residue | Details |
| A | TYR182-MET201 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"9468501","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Active site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 66 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37990007","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HFV","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |






