4AXE

Inositol 1,3,4,5,6-pentakisphosphate 2-kinase in complex with ADP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0010264	biological_process	myo-inositol hexakisphosphate biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0030643	biological_process	intracellular phosphate ion homeostasis
A	0032942	molecular_function	inositol-1,4,5,6-tetrakisphosphate 2-kinase activity
A	0032958	biological_process	inositol phosphate biosynthetic process
A	0035299	molecular_function	inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity
A	0042742	biological_process	defense response to bacterium
A	0046872	molecular_function	metal ion binding
A	0048527	biological_process	lateral root development
A	0050832	biological_process	defense response to fungus
A	0051607	biological_process	defense response to virus
A	0055062	biological_process	phosphate ion homeostasis
A	0102731	molecular_function	inositol-1,3,4,6-tetrakisphosphate 2-kinase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ADP A 1435

Chain	Residue
A	GLU18
A	HIS149
A	GLU166
A	PHE243
A	ASP407
A	HOH2004
A	HOH2005
A	GLY19
A	GLY20
A	ALA21
A	ASN22
A	VAL24
A	ARG40
A	ASN147
A	ASP148

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1436

Chain	Residue
A	HIS320
A	CYS330
A	CYS333
A	HIS346

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 1437

Chain	Residue
A	LYS168
A	LYS170
A	LYS200
A	ASN238
A	GLU255
A	SO41442
A	HOH2045

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1438

Chain	Residue
A	GLU18
A	ARG130
A	ARG241
A	GLY254
A	HOH2004

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1439

Chain	Residue
A	LYS230
A	TYR233
A	PRO262
A	LEU288

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 1440

Chain	Residue
A	GLY98
A	PRO99
A	LYS100
A	TYR203
A	ARG303
A	LYS425
A	HOH2065

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1441

Chain	Residue
A	ASN53
A	SER54
A	THR62
A	SER63

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1442

Chain	Residue
A	LYS170
A	ARG192
A	HIS196
A	SO41437
A	HOH2066

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Motif: {"description":"EXKPK motif"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20453199","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22745128","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20453199","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22362712","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22684075","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22745128","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22745128","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PDB","id":"2XAL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XAM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XAN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XAO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XAR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UDT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UDZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AQK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AXD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AXE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AXF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LV7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PDB","id":"2XAL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XAM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XAN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XAO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XAR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UDT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AQK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AXD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AXE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AXF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LV7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---