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4AW6

Crystal structure of the human nuclear membrane zinc metalloprotease ZMPSTE24 (FACE1)

GO(遺伝子オントロジー)由来の情報
鎖名GO(遺伝子オントロジー)id名前空間内容
A0001889biological_processliver development
A0001942biological_processhair follicle development
A0003007biological_processheart morphogenesis
A0003229biological_processventricular cardiac muscle tissue development
A0003231biological_processcardiac ventricle development
A0003417biological_processgrowth plate cartilage development
A0003690molecular_functiondouble-stranded DNA binding
A0004175molecular_functionendopeptidase activity
A0004222molecular_functionmetalloendopeptidase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005635cellular_componentnuclear envelope
A0005637cellular_componentnuclear inner membrane
A0005768cellular_componentendosome
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0006281biological_processDNA repair
A0006325biological_processchromatin organization
A0006355biological_processregulation of DNA-templated transcription
A0006508biological_processproteolysis
A0006925biological_processinflammatory cell apoptotic process
A0006974biological_processDNA damage response
A0006997biological_processnucleus organization
A0006998biological_processnuclear envelope organization
A0007346biological_processregulation of mitotic cell cycle
A0007628biological_processadult walking behavior
A0008016biological_processregulation of heart contraction
A0008233molecular_functionpeptidase activity
A0008235molecular_functionmetalloexopeptidase activity
A0008237molecular_functionmetallopeptidase activity
A0008340biological_processdetermination of adult lifespan
A0008360biological_processregulation of cell shape
A0008544biological_processepidermis development
A0010506biological_processregulation of autophagy
A0010628biological_processpositive regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0010906biological_processregulation of glucose metabolic process
A0016020cellular_componentmembrane
A0016485biological_processprotein processing
A0016787molecular_functionhydrolase activity
A0019216biological_processregulation of lipid metabolic process
A0030282biological_processbone mineralization
A0030327biological_processprenylated protein catabolic process
A0030500biological_processregulation of bone mineralization
A0031901cellular_componentearly endosome membrane
A0031902cellular_componentlate endosome membrane
A0032006biological_processregulation of TOR signaling
A0032350biological_processregulation of hormone metabolic process
A0032991cellular_componentprotein-containing complex
A0035264biological_processmulticellular organism growth
A0040014biological_processregulation of multicellular organism growth
A0040029biological_processepigenetic regulation of gene expression
A0043007biological_processmaintenance of rDNA
A0043516biological_processregulation of DNA damage response, signal transduction by p53 class mediator
A0044029biological_processpositive regulation of gene expression via chromosomal CpG island demethylation
A0044255biological_processcellular lipid metabolic process
A0046872molecular_functionmetal ion binding
A0048145biological_processregulation of fibroblast proliferation
A0048538biological_processthymus development
A0050688biological_processregulation of defense response to virus
A0050905biological_processneuromuscular process
A0051276biological_processchromosome organization
A0051604biological_processprotein maturation
A0055013biological_processcardiac muscle cell development
A0060307biological_processregulation of ventricular cardiac muscle cell membrane repolarization
A0060993biological_processkidney morphogenesis
A0061337biological_processcardiac conduction
A0061762biological_processCAMKK-AMPK signaling cascade
A0070062cellular_componentextracellular exosome
A0070302biological_processregulation of stress-activated protein kinase signaling cascade
A0071480biological_processcellular response to gamma radiation
A0071586biological_processCAAX-box protein processing
A0072423biological_processresponse to DNA damage checkpoint signaling
A1903463biological_processregulation of mitotic cell cycle DNA replication
A1903522biological_processregulation of blood circulation
A1903799biological_processnegative regulation of miRNA processing
A1990036biological_processcalcium ion import into sarcoplasmic reticulum
A2000730biological_processregulation of termination of RNA polymerase I transcription
A2000772biological_processregulation of cellular senescence
B0001889biological_processliver development
B0001942biological_processhair follicle development
B0003007biological_processheart morphogenesis
B0003229biological_processventricular cardiac muscle tissue development
B0003231biological_processcardiac ventricle development
B0003417biological_processgrowth plate cartilage development
B0003690molecular_functiondouble-stranded DNA binding
B0004175molecular_functionendopeptidase activity
B0004222molecular_functionmetalloendopeptidase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005635cellular_componentnuclear envelope
B0005637cellular_componentnuclear inner membrane
B0005768cellular_componentendosome
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0006281biological_processDNA repair
B0006325biological_processchromatin organization
B0006355biological_processregulation of DNA-templated transcription
B0006508biological_processproteolysis
B0006925biological_processinflammatory cell apoptotic process
B0006974biological_processDNA damage response
B0006997biological_processnucleus organization
B0006998biological_processnuclear envelope organization
B0007346biological_processregulation of mitotic cell cycle
B0007628biological_processadult walking behavior
B0008016biological_processregulation of heart contraction
B0008233molecular_functionpeptidase activity
B0008235molecular_functionmetalloexopeptidase activity
B0008237molecular_functionmetallopeptidase activity
B0008340biological_processdetermination of adult lifespan
B0008360biological_processregulation of cell shape
B0008544biological_processepidermis development
B0010506biological_processregulation of autophagy
B0010628biological_processpositive regulation of gene expression
B0010629biological_processnegative regulation of gene expression
B0010906biological_processregulation of glucose metabolic process
B0016020cellular_componentmembrane
B0016485biological_processprotein processing
B0016787molecular_functionhydrolase activity
B0019216biological_processregulation of lipid metabolic process
B0030282biological_processbone mineralization
B0030327biological_processprenylated protein catabolic process
B0030500biological_processregulation of bone mineralization
B0031901cellular_componentearly endosome membrane
B0031902cellular_componentlate endosome membrane
B0032006biological_processregulation of TOR signaling
B0032350biological_processregulation of hormone metabolic process
B0032991cellular_componentprotein-containing complex
B0035264biological_processmulticellular organism growth
B0040014biological_processregulation of multicellular organism growth
B0040029biological_processepigenetic regulation of gene expression
B0043007biological_processmaintenance of rDNA
B0043516biological_processregulation of DNA damage response, signal transduction by p53 class mediator
B0044029biological_processpositive regulation of gene expression via chromosomal CpG island demethylation
B0044255biological_processcellular lipid metabolic process
B0046872molecular_functionmetal ion binding
B0048145biological_processregulation of fibroblast proliferation
B0048538biological_processthymus development
B0050688biological_processregulation of defense response to virus
B0050905biological_processneuromuscular process
B0051276biological_processchromosome organization
B0051604biological_processprotein maturation
B0055013biological_processcardiac muscle cell development
B0060307biological_processregulation of ventricular cardiac muscle cell membrane repolarization
B0060993biological_processkidney morphogenesis
B0061337biological_processcardiac conduction
B0061762biological_processCAMKK-AMPK signaling cascade
B0070062cellular_componentextracellular exosome
B0070302biological_processregulation of stress-activated protein kinase signaling cascade
B0071480biological_processcellular response to gamma radiation
B0071586biological_processCAAX-box protein processing
B0072423biological_processresponse to DNA damage checkpoint signaling
B1903463biological_processregulation of mitotic cell cycle DNA replication
B1903522biological_processregulation of blood circulation
B1903799biological_processnegative regulation of miRNA processing
B1990036biological_processcalcium ion import into sarcoplasmic reticulum
B2000730biological_processregulation of termination of RNA polymerase I transcription
B2000772biological_processregulation of cellular senescence
D0001889biological_processliver development
D0001942biological_processhair follicle development
D0003007biological_processheart morphogenesis
D0003229biological_processventricular cardiac muscle tissue development
D0003231biological_processcardiac ventricle development
D0003417biological_processgrowth plate cartilage development
D0003690molecular_functiondouble-stranded DNA binding
D0004175molecular_functionendopeptidase activity
D0004222molecular_functionmetalloendopeptidase activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005635cellular_componentnuclear envelope
D0005637cellular_componentnuclear inner membrane
D0005768cellular_componentendosome
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0006281biological_processDNA repair
D0006325biological_processchromatin organization
D0006355biological_processregulation of DNA-templated transcription
D0006508biological_processproteolysis
D0006925biological_processinflammatory cell apoptotic process
D0006974biological_processDNA damage response
D0006997biological_processnucleus organization
D0006998biological_processnuclear envelope organization
D0007346biological_processregulation of mitotic cell cycle
D0007628biological_processadult walking behavior
D0008016biological_processregulation of heart contraction
D0008233molecular_functionpeptidase activity
D0008235molecular_functionmetalloexopeptidase activity
D0008237molecular_functionmetallopeptidase activity
D0008340biological_processdetermination of adult lifespan
D0008360biological_processregulation of cell shape
D0008544biological_processepidermis development
D0010506biological_processregulation of autophagy
D0010628biological_processpositive regulation of gene expression
D0010629biological_processnegative regulation of gene expression
D0010906biological_processregulation of glucose metabolic process
D0016020cellular_componentmembrane
D0016485biological_processprotein processing
D0016787molecular_functionhydrolase activity
D0019216biological_processregulation of lipid metabolic process
D0030282biological_processbone mineralization
D0030327biological_processprenylated protein catabolic process
D0030500biological_processregulation of bone mineralization
D0031901cellular_componentearly endosome membrane
D0031902cellular_componentlate endosome membrane
D0032006biological_processregulation of TOR signaling
D0032350biological_processregulation of hormone metabolic process
D0032991cellular_componentprotein-containing complex
D0035264biological_processmulticellular organism growth
D0040014biological_processregulation of multicellular organism growth
D0040029biological_processepigenetic regulation of gene expression
D0043007biological_processmaintenance of rDNA
D0043516biological_processregulation of DNA damage response, signal transduction by p53 class mediator
D0044029biological_processpositive regulation of gene expression via chromosomal CpG island demethylation
D0044255biological_processcellular lipid metabolic process
D0046872molecular_functionmetal ion binding
D0048145biological_processregulation of fibroblast proliferation
D0048538biological_processthymus development
D0050688biological_processregulation of defense response to virus
D0050905biological_processneuromuscular process
D0051276biological_processchromosome organization
D0051604biological_processprotein maturation
D0055013biological_processcardiac muscle cell development
D0060307biological_processregulation of ventricular cardiac muscle cell membrane repolarization
D0060993biological_processkidney morphogenesis
D0061337biological_processcardiac conduction
D0061762biological_processCAMKK-AMPK signaling cascade
D0070062cellular_componentextracellular exosome
D0070302biological_processregulation of stress-activated protein kinase signaling cascade
D0071480biological_processcellular response to gamma radiation
D0071586biological_processCAAX-box protein processing
D0072423biological_processresponse to DNA damage checkpoint signaling
D1903463biological_processregulation of mitotic cell cycle DNA replication
D1903522biological_processregulation of blood circulation
D1903799biological_processnegative regulation of miRNA processing
D1990036biological_processcalcium ion import into sarcoplasmic reticulum
D2000730biological_processregulation of termination of RNA polymerase I transcription
D2000772biological_processregulation of cellular senescence
E0001889biological_processliver development
E0001942biological_processhair follicle development
E0003007biological_processheart morphogenesis
E0003229biological_processventricular cardiac muscle tissue development
E0003231biological_processcardiac ventricle development
E0003417biological_processgrowth plate cartilage development
E0003690molecular_functiondouble-stranded DNA binding
E0004175molecular_functionendopeptidase activity
E0004222molecular_functionmetalloendopeptidase activity
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005635cellular_componentnuclear envelope
E0005637cellular_componentnuclear inner membrane
E0005768cellular_componentendosome
E0005783cellular_componentendoplasmic reticulum
E0005789cellular_componentendoplasmic reticulum membrane
E0006281biological_processDNA repair
E0006325biological_processchromatin organization
E0006355biological_processregulation of DNA-templated transcription
E0006508biological_processproteolysis
E0006925biological_processinflammatory cell apoptotic process
E0006974biological_processDNA damage response
E0006997biological_processnucleus organization
E0006998biological_processnuclear envelope organization
E0007346biological_processregulation of mitotic cell cycle
E0007628biological_processadult walking behavior
E0008016biological_processregulation of heart contraction
E0008233molecular_functionpeptidase activity
E0008235molecular_functionmetalloexopeptidase activity
E0008237molecular_functionmetallopeptidase activity
E0008340biological_processdetermination of adult lifespan
E0008360biological_processregulation of cell shape
E0008544biological_processepidermis development
E0010506biological_processregulation of autophagy
E0010628biological_processpositive regulation of gene expression
E0010629biological_processnegative regulation of gene expression
E0010906biological_processregulation of glucose metabolic process
E0016020cellular_componentmembrane
E0016485biological_processprotein processing
E0016787molecular_functionhydrolase activity
E0019216biological_processregulation of lipid metabolic process
E0030282biological_processbone mineralization
E0030327biological_processprenylated protein catabolic process
E0030500biological_processregulation of bone mineralization
E0031901cellular_componentearly endosome membrane
E0031902cellular_componentlate endosome membrane
E0032006biological_processregulation of TOR signaling
E0032350biological_processregulation of hormone metabolic process
E0032991cellular_componentprotein-containing complex
E0035264biological_processmulticellular organism growth
E0040014biological_processregulation of multicellular organism growth
E0040029biological_processepigenetic regulation of gene expression
E0043007biological_processmaintenance of rDNA
E0043516biological_processregulation of DNA damage response, signal transduction by p53 class mediator
E0044029biological_processpositive regulation of gene expression via chromosomal CpG island demethylation
E0044255biological_processcellular lipid metabolic process
E0046872molecular_functionmetal ion binding
E0048145biological_processregulation of fibroblast proliferation
E0048538biological_processthymus development
E0050688biological_processregulation of defense response to virus
E0050905biological_processneuromuscular process
E0051276biological_processchromosome organization
E0051604biological_processprotein maturation
E0055013biological_processcardiac muscle cell development
E0060307biological_processregulation of ventricular cardiac muscle cell membrane repolarization
E0060993biological_processkidney morphogenesis
E0061337biological_processcardiac conduction
E0061762biological_processCAMKK-AMPK signaling cascade
E0070062cellular_componentextracellular exosome
E0070302biological_processregulation of stress-activated protein kinase signaling cascade
E0071480biological_processcellular response to gamma radiation
E0071586biological_processCAAX-box protein processing
E0072423biological_processresponse to DNA damage checkpoint signaling
E1903463biological_processregulation of mitotic cell cycle DNA replication
E1903522biological_processregulation of blood circulation
E1903799biological_processnegative regulation of miRNA processing
E1990036biological_processcalcium ion import into sarcoplasmic reticulum
E2000730biological_processregulation of termination of RNA polymerase I transcription
E2000772biological_processregulation of cellular senescence
PDBデータベースに由来する情報
site_idAC1
残基数4
詳細BINDING SITE FOR RESIDUE ZN A 1473
鎖名残基
AHIS335
AGLU336
AHIS339
AGLU415

site_idAC2
残基数1
詳細BINDING SITE FOR RESIDUE PC1 A 1474
鎖名残基
APHE271

site_idAC3
残基数4
詳細BINDING SITE FOR RESIDUE ZN B 1473
鎖名残基
BHIS335
BGLU336
BHIS339
BGLU415

site_idAC4
残基数1
詳細BINDING SITE FOR RESIDUE PC1 B 1474
鎖名残基
BPHE271

site_idAC5
残基数4
詳細BINDING SITE FOR RESIDUE ZN D 1472
鎖名残基
DHIS335
DGLU336
DHIS339
DGLU415

site_idAC6
残基数1
詳細BINDING SITE FOR RESIDUE PC1 D 1473
鎖名残基
DPHE271

site_idAC7
残基数4
詳細BINDING SITE FOR RESIDUE ZN E 1472
鎖名残基
EHIS335
EGLU336
EHIS339
EGLU415

site_idAC8
残基数1
詳細BINDING SITE FOR RESIDUE PC1 E 1473
鎖名残基
EPHE271

SwissProt/UniProtに記載されている蛋白質分子機能情報
site_idSWS_FT_FI1
残基数212
詳細TOPO_DOM: Lumenal => ECO:0000255
鎖名残基詳細
AMET1-ARG18
DARG103-SER123
DGLY192-TYR195
DARG369-GLN382
EMET1-ARG18
EARG103-SER123
EGLY192-TYR195
EARG369-GLN382
AARG103-SER123
AGLY192-TYR195
AARG369-GLN382
BMET1-ARG18
BARG103-SER123
BGLY192-TYR195
BARG369-GLN382
DMET1-ARG18

site_idSWS_FT_FI2
残基数568
詳細TRANSMEM: Helical => ECO:0000255
鎖名残基詳細
AILE19-GLN39
BLEU124-TYR144
BPHE171-ILE191
BPHE196-ALA216
BASN348-GLY368
BPRO383-PHE405
DILE19-GLN39
DGLY82-TRP102
DLEU124-TYR144
DPHE171-ILE191
DPHE196-ALA216
AGLY82-TRP102
DASN348-GLY368
DPRO383-PHE405
EILE19-GLN39
EGLY82-TRP102
ELEU124-TYR144
EPHE171-ILE191
EPHE196-ALA216
EASN348-GLY368
EPRO383-PHE405
ALEU124-TYR144
APHE171-ILE191
APHE196-ALA216
AASN348-GLY368
APRO383-PHE405
BILE19-GLN39
BGLY82-TRP102

site_idSWS_FT_FI3
残基数1060
詳細TOPO_DOM: Nuclear => ECO:0000255
鎖名残基詳細
AARG40-SER81
DASN145-LYS170
DASP217-LYS347
DCYS406-HIS475
EARG40-SER81
EASN145-LYS170
EASP217-LYS347
ECYS406-HIS475
AASN145-LYS170
AASP217-LYS347
ACYS406-HIS475
BARG40-SER81
BASN145-LYS170
BASP217-LYS347
BCYS406-HIS475
DARG40-SER81

site_idSWS_FT_FI4
残基数4
詳細ACT_SITE: ACT_SITE => ECO:0000269|PubMed:23539603
鎖名残基詳細
AGLU336
BGLU336
DGLU336
EGLU336

site_idSWS_FT_FI5
残基数12
詳細BINDING: BINDING => ECO:0000269|PubMed:23539603
鎖名残基詳細
AHIS335
EHIS335
EHIS339
EGLU415
AHIS339
AGLU415
BHIS335
BHIS339
BGLU415
DHIS335
DHIS339
DGLU415

218853

件を2024-04-24に公開中

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