4AVA

Crystal structure of protein lysine acetyltransferase Rv0998 from Mycobacterium tuberculosis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005829	cellular_component	cytosol
A	0006355	biological_process	regulation of DNA-templated transcription
A	0016407	molecular_function	acetyltransferase activity
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0030552	molecular_function	cAMP binding
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	36
Details	BINDING SITE FOR RESIDUE ACO A 1334

Chain	Residue
A	ARG136
A	VAL240
A	GLN245
A	GLY246
A	ARG247
A	GLY248
A	ILE249
A	GLY250
A	SER251
A	ARG272
A	ASN277
A	ALA140
A	PRO279
A	MET280
A	THR282
A	ILE283
A	ARG286
A	EDO1337
A	PEG1341
A	HOH2108
A	HOH2172
A	HOH2178
A	VAL143
A	HOH2179
A	HOH2184
A	HOH2185
A	HOH2198
A	HOH2200
A	HOH2237
A	HOH2239
A	PRO145
A	HIS173
A	ILE236
A	ALA237
A	PHE238
A	THR239

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT A 1335

Chain	Residue
A	HIS173
A	HOH2048
A	HOH2193
A	HOH2240
A	HOH2241

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1336

Chain	Residue
A	GLU167
A	ALA220
A	ASP221
A	ALA241
A	HOH2130

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1337

Chain	Residue
A	ARG286
A	SER312
A	ACO1334
A	HOH2215

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 1338

Chain	Residue
A	PRO145
A	PRO147
A	SER275
A	ASP276
A	VAL278
A	HOH2029
A	HOH2196

---

site_id	AC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE EDO A 1339

Chain	Residue
A	ASP95
A	HIS171
A	GLY172
A	HIS173
A	ALA237
A	THR239
A	HOH2055
A	HOH2134
A	HOH2139
A	HOH2162
A	HOH2166
A	HOH2240

---

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PEG A 1340

Chain	Residue
A	GLY215
A	ARG281
A	ASP285
A	TRP291
A	HOH2158
A	HOH2159
A	HOH2161
A	HOH2203
A	HOH2208

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PEG A 1341

Chain	Residue
A	ARG133
A	ARG136
A	GLN137
A	ALA140
A	GLY246
A	ACO1334
A	HOH2179

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 1342

Chain	Residue
A	ASP214
A	HOH2121
A	HOH2158
A	HOH2159
A	HOH2160
A	HOH2242

---

Functional Information from PROSITE/UniProt

site_id	PS00889
Number of Residues	18
Details	CNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. VGEiALlrdsp......RSAtVtT

Chain	Residue	Details
A	VAL87-THR104

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22773105","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4AVB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AVC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22773105","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22773105","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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