4AUL
Crystal structure, recombinant expression and mutagenesis studies of the bifunctional catalase-phenol oxidase from Scytalidium thermophilum
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004096 | molecular_function | catalase activity |
| A | 0004097 | molecular_function | catechol oxidase activity |
| A | 0004601 | molecular_function | peroxidase activity |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0020037 | molecular_function | heme binding |
| A | 0042744 | biological_process | hydrogen peroxide catabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| B | 0004096 | molecular_function | catalase activity |
| B | 0004097 | molecular_function | catechol oxidase activity |
| B | 0004601 | molecular_function | peroxidase activity |
| B | 0006979 | biological_process | response to oxidative stress |
| B | 0020037 | molecular_function | heme binding |
| B | 0042744 | biological_process | hydrogen peroxide catabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0098869 | biological_process | cellular oxidant detoxification |
| C | 0004096 | molecular_function | catalase activity |
| C | 0004097 | molecular_function | catechol oxidase activity |
| C | 0004601 | molecular_function | peroxidase activity |
| C | 0006979 | biological_process | response to oxidative stress |
| C | 0020037 | molecular_function | heme binding |
| C | 0042744 | biological_process | hydrogen peroxide catabolic process |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0098869 | biological_process | cellular oxidant detoxification |
| D | 0004096 | molecular_function | catalase activity |
| D | 0004097 | molecular_function | catechol oxidase activity |
| D | 0004601 | molecular_function | peroxidase activity |
| D | 0006979 | biological_process | response to oxidative stress |
| D | 0020037 | molecular_function | heme binding |
| D | 0042744 | biological_process | hydrogen peroxide catabolic process |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE HEM A 754 |
| Chain | Residue |
| A | ARG79 |
| A | PHE168 |
| A | VAL228 |
| A | HIS229 |
| A | PHE345 |
| A | LEU361 |
| A | ARG365 |
| A | SER368 |
| A | TYR369 |
| A | THR372 |
| A | GLN373 |
| A | VAL81 |
| A | ARG376 |
| A | HOH2118 |
| A | HOH2184 |
| A | HOH2443 |
| C | ASP72 |
| A | ASN82 |
| A | ARG119 |
| A | GLY138 |
| A | VAL153 |
| A | GLY154 |
| A | ASN155 |
| A | PHE160 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 1699 |
| Chain | Residue |
| A | ARG178 |
| A | HIS190 |
| A | SER192 |
| A | HOH2771 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA A 1700 |
| Chain | Residue |
| A | THR437 |
| A | HOH2773 |
| B | ARG449 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1701 |
| Chain | Residue |
| A | HOH2471 |
| A | HOH2472 |
| A | HOH2774 |
| A | HOH2775 |
| A | HOH2776 |
| A | HOH2777 |
| site_id | AC5 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE HEM B 754 |
| Chain | Residue |
| B | ARG79 |
| B | VAL81 |
| B | ASN82 |
| B | ARG119 |
| B | GLY138 |
| B | VAL153 |
| B | GLY154 |
| B | ASN155 |
| B | PHE160 |
| B | PHE168 |
| B | VAL228 |
| B | HIS229 |
| B | PHE345 |
| B | LEU361 |
| B | ARG365 |
| B | SER368 |
| B | TYR369 |
| B | THR372 |
| B | GLN373 |
| B | ARG376 |
| B | HOH2109 |
| B | HOH2165 |
| B | HOH2409 |
| D | ASP72 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 1699 |
| Chain | Residue |
| A | HOH2523 |
| B | HIS190 |
| B | ASP191 |
| B | SER192 |
| B | HOH2709 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CA B 1700 |
| Chain | Residue |
| B | SER255 |
| B | HOH2272 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA B 1701 |
| Chain | Residue |
| A | ARG449 |
| A | HOH2570 |
| B | THR437 |
| B | HOH2710 |
| site_id | AC9 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE HEM C 754 |
| Chain | Residue |
| A | ASP72 |
| C | ARG79 |
| C | VAL81 |
| C | ASN82 |
| C | ARG119 |
| C | GLY138 |
| C | VAL153 |
| C | GLY154 |
| C | ASN155 |
| C | PHE160 |
| C | ALA165 |
| C | PHE168 |
| C | HIS229 |
| C | PHE345 |
| C | LEU361 |
| C | ARG365 |
| C | SER368 |
| C | TYR369 |
| C | THR372 |
| C | GLN373 |
| C | ARG376 |
| C | HOH2038 |
| C | HOH2087 |
| C | HOH2299 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA C 1699 |
| Chain | Residue |
| C | HOH2156 |
| C | ARG178 |
| C | HIS190 |
| C | SER192 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CA C 1700 |
| Chain | Residue |
| C | SER255 |
| C | HOH2189 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA C 1701 |
| Chain | Residue |
| C | HIS214 |
| C | LYS253 |
| C | HOH2127 |
| site_id | BC4 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE HEM D 754 |
| Chain | Residue |
| B | ASP72 |
| D | ARG79 |
| D | VAL81 |
| D | ASN82 |
| D | ARG119 |
| D | GLY138 |
| D | VAL153 |
| D | GLY154 |
| D | ASN155 |
| D | PHE160 |
| D | ALA165 |
| D | PHE168 |
| D | VAL228 |
| D | HIS229 |
| D | PHE345 |
| D | LEU361 |
| D | ARG365 |
| D | SER368 |
| D | TYR369 |
| D | THR372 |
| D | GLN373 |
| D | ARG376 |
| D | HOH2033 |
| D | HOH2080 |
| D | HOH2271 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA D 1699 |
| Chain | Residue |
| D | ARG178 |
| D | HIS190 |
| D | SER192 |
| D | HOH2469 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA D 1700 |
| Chain | Residue |
| D | SER255 |
| D | HOH2166 |
| D | HOH2208 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA D 1701 |
| Chain | Residue |
| A | LYS323 |
| D | ALA431 |
| D | ARG433 |
Functional Information from PROSITE/UniProt
