Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4ATQ

GABA-transaminase A1R958 in complex with external aldimine PLP-GABA adduct

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008483	molecular_function	transaminase activity
A	0009448	biological_process	gamma-aminobutyric acid metabolic process
A	0016740	molecular_function	transferase activity
A	0019752	biological_process	carboxylic acid metabolic process
A	0030170	molecular_function	pyridoxal phosphate binding
A	0034386	molecular_function	4-aminobutyrate:2-oxoglutarate transaminase activity
A	0042802	molecular_function	identical protein binding
A	0047298	molecular_function	(S)-3-amino-2-methylpropionate transaminase activity
A	0047589	molecular_function	5-aminovalerate transaminase activity
B	0008483	molecular_function	transaminase activity
B	0009448	biological_process	gamma-aminobutyric acid metabolic process
B	0016740	molecular_function	transferase activity
B	0019752	biological_process	carboxylic acid metabolic process
B	0030170	molecular_function	pyridoxal phosphate binding
B	0034386	molecular_function	4-aminobutyrate:2-oxoglutarate transaminase activity
B	0042802	molecular_function	identical protein binding
B	0047298	molecular_function	(S)-3-amino-2-methylpropionate transaminase activity
B	0047589	molecular_function	5-aminovalerate transaminase activity
C	0008483	molecular_function	transaminase activity
C	0009448	biological_process	gamma-aminobutyric acid metabolic process
C	0016740	molecular_function	transferase activity
C	0019752	biological_process	carboxylic acid metabolic process
C	0030170	molecular_function	pyridoxal phosphate binding
C	0034386	molecular_function	4-aminobutyrate:2-oxoglutarate transaminase activity
C	0042802	molecular_function	identical protein binding
C	0047298	molecular_function	(S)-3-amino-2-methylpropionate transaminase activity
C	0047589	molecular_function	5-aminovalerate transaminase activity
D	0008483	molecular_function	transaminase activity
D	0009448	biological_process	gamma-aminobutyric acid metabolic process
D	0016740	molecular_function	transferase activity
D	0019752	biological_process	carboxylic acid metabolic process
D	0030170	molecular_function	pyridoxal phosphate binding
D	0034386	molecular_function	4-aminobutyrate:2-oxoglutarate transaminase activity
D	0042802	molecular_function	identical protein binding
D	0047298	molecular_function	(S)-3-amino-2-methylpropionate transaminase activity
D	0047589	molecular_function	5-aminovalerate transaminase activity
E	0008483	molecular_function	transaminase activity
E	0009448	biological_process	gamma-aminobutyric acid metabolic process
E	0016740	molecular_function	transferase activity
E	0019752	biological_process	carboxylic acid metabolic process
E	0030170	molecular_function	pyridoxal phosphate binding
E	0034386	molecular_function	4-aminobutyrate:2-oxoglutarate transaminase activity
E	0042802	molecular_function	identical protein binding
E	0047298	molecular_function	(S)-3-amino-2-methylpropionate transaminase activity
E	0047589	molecular_function	5-aminovalerate transaminase activity
F	0008483	molecular_function	transaminase activity
F	0009448	biological_process	gamma-aminobutyric acid metabolic process
F	0016740	molecular_function	transferase activity
F	0019752	biological_process	carboxylic acid metabolic process
F	0030170	molecular_function	pyridoxal phosphate binding
F	0034386	molecular_function	4-aminobutyrate:2-oxoglutarate transaminase activity
F	0042802	molecular_function	identical protein binding
F	0047298	molecular_function	(S)-3-amino-2-methylpropionate transaminase activity
F	0047589	molecular_function	5-aminovalerate transaminase activity
G	0008483	molecular_function	transaminase activity
G	0009448	biological_process	gamma-aminobutyric acid metabolic process
G	0016740	molecular_function	transferase activity
G	0019752	biological_process	carboxylic acid metabolic process
G	0030170	molecular_function	pyridoxal phosphate binding
G	0034386	molecular_function	4-aminobutyrate:2-oxoglutarate transaminase activity
G	0042802	molecular_function	identical protein binding
G	0047298	molecular_function	(S)-3-amino-2-methylpropionate transaminase activity
G	0047589	molecular_function	5-aminovalerate transaminase activity
H	0008483	molecular_function	transaminase activity
H	0009448	biological_process	gamma-aminobutyric acid metabolic process
H	0016740	molecular_function	transferase activity
H	0019752	biological_process	carboxylic acid metabolic process
H	0030170	molecular_function	pyridoxal phosphate binding
H	0034386	molecular_function	4-aminobutyrate:2-oxoglutarate transaminase activity
H	0042802	molecular_function	identical protein binding
H	0047298	molecular_function	(S)-3-amino-2-methylpropionate transaminase activity
H	0047589	molecular_function	5-aminovalerate transaminase activity
I	0008483	molecular_function	transaminase activity
I	0009448	biological_process	gamma-aminobutyric acid metabolic process
I	0016740	molecular_function	transferase activity
I	0019752	biological_process	carboxylic acid metabolic process
I	0030170	molecular_function	pyridoxal phosphate binding
I	0034386	molecular_function	4-aminobutyrate:2-oxoglutarate transaminase activity
I	0042802	molecular_function	identical protein binding
I	0047298	molecular_function	(S)-3-amino-2-methylpropionate transaminase activity
I	0047589	molecular_function	5-aminovalerate transaminase activity
J	0008483	molecular_function	transaminase activity
J	0009448	biological_process	gamma-aminobutyric acid metabolic process
J	0016740	molecular_function	transferase activity
J	0019752	biological_process	carboxylic acid metabolic process
J	0030170	molecular_function	pyridoxal phosphate binding
J	0034386	molecular_function	4-aminobutyrate:2-oxoglutarate transaminase activity
J	0042802	molecular_function	identical protein binding
J	0047298	molecular_function	(S)-3-amino-2-methylpropionate transaminase activity
J	0047589	molecular_function	5-aminovalerate transaminase activity
K	0008483	molecular_function	transaminase activity
K	0009448	biological_process	gamma-aminobutyric acid metabolic process
K	0016740	molecular_function	transferase activity
K	0019752	biological_process	carboxylic acid metabolic process
K	0030170	molecular_function	pyridoxal phosphate binding
K	0034386	molecular_function	4-aminobutyrate:2-oxoglutarate transaminase activity
K	0042802	molecular_function	identical protein binding
K	0047298	molecular_function	(S)-3-amino-2-methylpropionate transaminase activity
K	0047589	molecular_function	5-aminovalerate transaminase activity
L	0008483	molecular_function	transaminase activity
L	0009448	biological_process	gamma-aminobutyric acid metabolic process
L	0016740	molecular_function	transferase activity
L	0019752	biological_process	carboxylic acid metabolic process
L	0030170	molecular_function	pyridoxal phosphate binding
L	0034386	molecular_function	4-aminobutyrate:2-oxoglutarate transaminase activity
L	0042802	molecular_function	identical protein binding
L	0047298	molecular_function	(S)-3-amino-2-methylpropionate transaminase activity
L	0047589	molecular_function	5-aminovalerate transaminase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PLP A 1456

Chain	Residue
A	SER133
A	LYS295
A	ABU1457
A	HOH2057
A	HOH2076
B	THR324
A	GLY134
A	ALA135
A	TYR161
A	HIS162
A	GLU233
A	ASP266
A	VAL268
A	GLN269

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE ABU A 1457

Chain	Residue
A	TYR161
A	ARG164
A	GLU238
A	LYS295
A	PLP1456
A	HOH2057
B	MET102
B	GLY323
B	THR324

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE PLP B 1456

Chain	Residue
A	THR324
A	HOH2042
A	HOH2043
B	SER133
B	GLY134
B	ALA135
B	TYR161
B	HIS162
B	GLU233
B	ASP266
B	VAL268
B	GLN269
B	LYS295
B	ABU1457
B	HOH2077

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ABU B 1457

Chain	Residue
A	MET102
A	GLY323
A	THR324
B	TYR161
B	ARG164
B	GLU238
B	LYS295
B	PLP1456

site_id	AC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PLP C 1456

Chain	Residue
C	SER133
C	GLY134
C	ALA135
C	TYR161
C	HIS162
C	GLU233
C	ASP266
C	VAL268
C	GLN269
C	LYS295
C	ABU1457
C	HOH2033
D	THR324

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ABU C 1457

Chain	Residue
C	TYR161
C	ARG164
C	LYS295
C	PLP1456
D	MET102
D	GLY323
D	THR324

site_id	AC7
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PLP D 1456

Chain	Residue
C	THR324
D	SER133
D	GLY134
D	ALA135
D	TYR161
D	HIS162
D	GLU233
D	ASP266
D	VAL268
D	GLN269
D	LYS295
D	ABU1457
D	HOH2019
D	HOH2030

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ABU D 1457

Chain	Residue
C	MET102
D	TYR161
D	ARG164
D	GLU238
D	LYS295
D	PLP1456
D	HOH2019
D	HOH2021

site_id	AC9
Number of Residues	15
Details	BINDING SITE FOR RESIDUE PLP E 1456

Chain	Residue
E	HOH2064
E	HOH2078
E	HOH2079
F	THR324
E	SER133
E	GLY134
E	ALA135
E	TYR161
E	HIS162
E	GLU233
E	ASP266
E	VAL268
E	GLN269
E	LYS295
E	ABU1457

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ABU E 1457

Chain	Residue
E	TYR161
E	ARG164
E	GLU238
E	LYS295
E	PLP1456
F	MET102
F	GLY323

site_id	BC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE PLP F 1456

Chain	Residue
E	THR324
E	HOH2035
F	SER133
F	GLY134
F	ALA135
F	TYR161
F	HIS162
F	GLU233
F	ASP266
F	VAL268
F	GLN269
F	LYS295
F	ABU1457
F	HOH2034
F	HOH2036
F	HOH2056
F	HOH2066

site_id	BC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE ABU F 1457

Chain	Residue
E	GLY323
E	THR324
F	TYR161
F	ARG164
F	TYR178
F	GLU238
F	LYS295
F	PLP1456
F	HOH2034

site_id	BC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PLP I 1457

Chain	Residue
I	SER133
I	GLY134
I	ALA135
I	TYR161
I	HIS162
I	GLU233
I	ASP266
I	VAL268
I	GLN269
I	LYS295
I	ABU1458
I	HOH2005
L	THR324

site_id	BC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ABU I 1458

Chain	Residue
I	TYR161
I	ARG164
I	GLU238
I	LYS295
I	PLP1457
L	MET102
L	GLY323
L	THR324

site_id	BC6
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PLP J 1456

Chain	Residue
J	SER133
J	GLY134
J	ALA135
J	TYR161
J	HIS162
J	GLU233
J	ASP266
J	LYS295
J	ABU1457
K	GLY323
K	THR324

site_id	BC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE ABU J 1457

Chain	Residue
J	TYR161
J	ARG164
J	TYR178
J	GLU238
J	LYS295
J	PLP1456
K	MET102
K	GLY323
K	THR324

site_id	BC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PLP K 1456

Chain	Residue
J	THR324
K	GLY134
K	ALA135
K	TYR161
K	HIS162
K	GLU233
K	ASP266
K	GLN269
K	LYS295
K	ABU1457
K	HOH2004

site_id	BC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ABU K 1457

Chain	Residue
J	MET102
J	GLY323
J	THR324
K	TYR161
K	ARG164
K	GLU238
K	LYS295
K	PLP1456

site_id	CC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PLP G 1456

Chain	Residue
G	SER133
G	GLY134
G	ALA135
G	TYR161
G	HIS162
G	GLU233
G	ASP266
G	GLN269
G	LYS295
G	ABU1457
H	THR324

site_id	CC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ABU G 1457

Chain	Residue
G	TYR161
G	ARG164
G	TYR178
G	GLU238
G	LYS295
G	PLP1456
H	MET102
H	THR324

site_id	CC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PLP H 1456

Chain	Residue
G	THR324
H	SER133
H	GLY134
H	ALA135
H	TYR161
H	HIS162
H	GLU233
H	ASP266
H	VAL268
H	GLN269
H	LYS295
H	ABU1457

site_id	CC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ABU H 1457

Chain	Residue
G	MET102
G	GLY323
G	THR324
H	TYR161
H	ARG164
H	GLU238
H	LYS295
H	PLP1456

site_id	CC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PLP L 1456

Chain	Residue
I	THR324
L	SER133
L	GLY134
L	ALA135
L	TYR161
L	HIS162
L	GLU233
L	ASP266
L	GLN269
L	LYS295
L	ABU1457

site_id	CC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ABU L 1457

Chain	Residue
I	MET102
I	THR324
L	TYR161
L	ARG164
L	TYR178
L	GLU238
L	LYS295
L	PLP1456

Functional Information from PROSITE/UniProt

site_id	PS00600
Number of Residues	38
Details	AA_TRANSFER_CLASS_3 Aminotransferases class-III pyridoxal-phosphate attachment site. FIaDEVqs.GFcRtGewfavdhegvvp....DIItmAKgiaGG

Chain	Residue	Details
A	PHE263-GLY300

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)