4AT2
The crystal structure of 3-ketosteroid-delta4-(5alpha)-dehydrogenase from Rhodococcus jostii RHA1 in complex with 4-androstene-3,17- dione
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003865 | molecular_function | 3-oxo-5-alpha-steroid 4-dehydrogenase activity |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0008202 | biological_process | steroid metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0033765 | molecular_function | steroid dehydrogenase activity, acting on the CH-CH group of donors |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE ASD A 1490 |
| Chain | Residue |
| A | TRP136 |
| A | HOH2617 |
| A | GLU290 |
| A | ALA292 |
| A | TYR319 |
| A | TYR466 |
| A | SER468 |
| A | GLY469 |
| A | FAD1492 |
| A | HOH2616 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 1491 |
| Chain | Residue |
| A | ALA264 |
| A | HOH2618 |
| site_id | AC3 |
| Number of Residues | 41 |
| Details | BINDING SITE FOR RESIDUE FAD A 1492 |
| Chain | Residue |
| A | GLY28 |
| A | GLY30 |
| A | ILE31 |
| A | ALA32 |
| A | LEU50 |
| A | GLU51 |
| A | ARG52 |
| A | THR53 |
| A | GLY58 |
| A | ALA59 |
| A | THR60 |
| A | ALA63 |
| A | GLY64 |
| A | GLY65 |
| A | PHE66 |
| A | THR175 |
| A | MET203 |
| A | VAL205 |
| A | ALA239 |
| A | THR240 |
| A | GLY241 |
| A | GLY262 |
| A | ILE265 |
| A | GLU267 |
| A | HIS268 |
| A | PHE427 |
| A | GLY455 |
| A | ARG456 |
| A | TYR466 |
| A | GLY469 |
| A | THR470 |
| A | SER471 |
| A | LEU472 |
| A | ASD1490 |
| A | HOH2034 |
| A | HOH2079 |
| A | HOH2086 |
| A | HOH2103 |
| A | HOH2366 |
| A | HOH2602 |
| A | HOH2618 |
