4AT2

The crystal structure of 3-ketosteroid-delta4-(5alpha)-dehydrogenase from Rhodococcus jostii RHA1 in complex with 4-androstene-3,17- dione

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0008202	biological_process	steroid metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0033765	molecular_function	steroid dehydrogenase activity, acting on the CH-CH group of donors

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ASD A 1490

Chain	Residue
A	TRP136
A	HOH2617
A	GLU290
A	ALA292
A	TYR319
A	TYR466
A	SER468
A	GLY469
A	FAD1492
A	HOH2616

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site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 1491

Chain	Residue
A	ALA264
A	HOH2618

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site_id	AC3
Number of Residues	41
Details	BINDING SITE FOR RESIDUE FAD A 1492

Chain	Residue
A	GLY28
A	GLY30
A	ILE31
A	ALA32
A	LEU50
A	GLU51
A	ARG52
A	THR53
A	GLY58
A	ALA59
A	THR60
A	ALA63
A	GLY64
A	GLY65
A	PHE66
A	THR175
A	MET203
A	VAL205
A	ALA239
A	THR240
A	GLY241
A	GLY262
A	ILE265
A	GLU267
A	HIS268
A	PHE427
A	GLY455
A	ARG456
A	TYR466
A	GLY469
A	THR470
A	SER471
A	LEU472
A	ASD1490
A	HOH2034
A	HOH2079
A	HOH2086
A	HOH2103
A	HOH2366
A	HOH2602
A	HOH2618

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