4AT0
The crystal structure of 3-ketosteroid-delta4-(5alpha)-dehydrogenase from Rhodococcus jostii RHA1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003865 | molecular_function | 3-oxo-5-alpha-steroid 4-dehydrogenase activity |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0008202 | biological_process | steroid metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0033765 | molecular_function | steroid dehydrogenase activity, acting on the CH-CH group of donors |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT A 1490 |
| Chain | Residue |
| A | TYR466 |
| A | SER468 |
| A | GLY469 |
| A | ACT1491 |
| A | FAD1493 |
| A | HOH2447 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT A 1491 |
| Chain | Residue |
| A | FAD1493 |
| A | HOH2447 |
| A | HOH2605 |
| A | GLY64 |
| A | GLU137 |
| A | ACT1490 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 1492 |
| Chain | Residue |
| A | ALA95 |
| A | GLY97 |
| A | ARG322 |
| A | HOH2164 |
| A | HOH2451 |
| A | HOH2606 |
| site_id | AC4 |
| Number of Residues | 41 |
| Details | BINDING SITE FOR RESIDUE FAD A 1493 |
| Chain | Residue |
| A | GLY28 |
| A | GLY30 |
| A | ILE31 |
| A | ALA32 |
| A | LEU50 |
| A | GLU51 |
| A | ARG52 |
| A | THR53 |
| A | GLY58 |
| A | ALA59 |
| A | THR60 |
| A | ALA63 |
| A | GLY64 |
| A | GLY65 |
| A | PHE66 |
| A | MET203 |
| A | VAL205 |
| A | ALA239 |
| A | THR240 |
| A | GLY241 |
| A | GLY262 |
| A | ILE265 |
| A | GLU267 |
| A | HIS268 |
| A | PHE427 |
| A | GLY455 |
| A | ARG456 |
| A | TYR466 |
| A | GLY469 |
| A | THR470 |
| A | SER471 |
| A | LEU472 |
| A | ACT1490 |
| A | ACT1491 |
| A | HOH2039 |
| A | HOH2086 |
| A | HOH2094 |
| A | HOH2110 |
| A | HOH2363 |
| A | HOH2593 |
| A | HOH2608 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 1494 |
| Chain | Residue |
| A | ALA263 |
| A | ALA264 |
| A | HOH2608 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 284 |
| Details | Region: {"description":"F1","evidences":[{"source":"PubMed","id":"22833669","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 133 |
| Details | Region: {"description":"Substrate-binding domain","evidences":[{"source":"PubMed","id":"22833669","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"22833669","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 13 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22833669","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4AT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AT2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Site: {"description":"Important for catalytic activity","evidences":[{"source":"PubMed","id":"22833669","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
