4ASZ

Crystal structure of apo TrkB kinase domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
A	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
A	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	29
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFGKVFlAecynlcpeqdkil.....VAVK

Chain	Residue	Details
A	LEU560-LYS588

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site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDLATRNCLV

Chain	Residue	Details
A	PHE688-VAL700

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site_id	PS00239
Number of Residues	9
Details	RECEPTOR_TYR_KIN_II Receptor tyrosine kinase class II signature. DVYstdYYR

Chain	Residue	Details
A	ASP716-ARG724

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028

Chain	Residue	Details
A	ILE676

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	THR544
A	GLU572

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Interaction with SH2D1A => ECO:0000250

Chain	Residue	Details
A	VAL706

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site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Interaction with PLCG1 => ECO:0000250

Chain	Residue	Details
A	LYS817

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site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000250|UniProtKB:Q63604

Chain	Residue	Details
A	GLU702
A	VAL706
A	LYS707
A	LYS817

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