4AST

The apo structure of a bacterial aldo-keto reductase AKR14A1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006974	biological_process	DNA damage response
A	0008106	molecular_function	alcohol dehydrogenase (NADP+) activity
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0051596	biological_process	methylglyoxal catabolic process
A	1990002	molecular_function	methylglyoxal reductase (NADPH) (acetol producing) activity
B	0006974	biological_process	DNA damage response
B	0008106	molecular_function	alcohol dehydrogenase (NADP+) activity
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0051596	biological_process	methylglyoxal catabolic process
B	1990002	molecular_function	methylglyoxal reductase (NADPH) (acetol producing) activity
C	0006974	biological_process	DNA damage response
C	0008106	molecular_function	alcohol dehydrogenase (NADP+) activity
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0051596	biological_process	methylglyoxal catabolic process
C	1990002	molecular_function	methylglyoxal reductase (NADPH) (acetol producing) activity
D	0006974	biological_process	DNA damage response
D	0008106	molecular_function	alcohol dehydrogenase (NADP+) activity
D	0016491	molecular_function	oxidoreductase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0051596	biological_process	methylglyoxal catabolic process
D	1990002	molecular_function	methylglyoxal reductase (NADPH) (acetol producing) activity
E	0006974	biological_process	DNA damage response
E	0008106	molecular_function	alcohol dehydrogenase (NADP+) activity
E	0016491	molecular_function	oxidoreductase activity
E	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
E	0051596	biological_process	methylglyoxal catabolic process
E	1990002	molecular_function	methylglyoxal reductase (NADPH) (acetol producing) activity
F	0006974	biological_process	DNA damage response
F	0008106	molecular_function	alcohol dehydrogenase (NADP+) activity
F	0016491	molecular_function	oxidoreductase activity
F	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
F	0051596	biological_process	methylglyoxal catabolic process
F	1990002	molecular_function	methylglyoxal reductase (NADPH) (acetol producing) activity
G	0006974	biological_process	DNA damage response
G	0008106	molecular_function	alcohol dehydrogenase (NADP+) activity
G	0016491	molecular_function	oxidoreductase activity
G	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
G	0051596	biological_process	methylglyoxal catabolic process
G	1990002	molecular_function	methylglyoxal reductase (NADPH) (acetol producing) activity
H	0006974	biological_process	DNA damage response
H	0008106	molecular_function	alcohol dehydrogenase (NADP+) activity
H	0016491	molecular_function	oxidoreductase activity
H	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
H	0051596	biological_process	methylglyoxal catabolic process
H	1990002	molecular_function	methylglyoxal reductase (NADPH) (acetol producing) activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	88
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23103600","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4AUB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	32
Details	Site: {"description":"Important for catalysis","evidences":[{"source":"PubMed","id":"22393408","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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