4ARZ

The crystal structure of Gtr1p-Gtr2p complexed with GTP-GDP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000329	cellular_component	fungal-type vacuole membrane
A	0000781	cellular_component	chromosome, telomeric region
A	0003924	molecular_function	GTPase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005770	cellular_component	late endosome
A	0005774	cellular_component	vacuolar membrane
A	0006360	biological_process	transcription by RNA polymerase I
A	0006383	biological_process	transcription by RNA polymerase III
A	0006817	biological_process	phosphate ion transport
A	0006995	biological_process	cellular response to nitrogen starvation
A	0009267	biological_process	cellular response to starvation
A	0010507	biological_process	negative regulation of autophagy
A	0016237	biological_process	microautophagy
A	0016787	molecular_function	hydrolase activity
A	0031509	biological_process	subtelomeric heterochromatin formation
A	0031902	cellular_component	late endosome membrane
A	0032008	biological_process	positive regulation of TOR signaling
A	0032456	biological_process	endocytic recycling
A	0034599	biological_process	cellular response to oxidative stress
A	0042802	molecular_function	identical protein binding
A	0071230	biological_process	cellular response to amino acid stimulus
A	0071986	cellular_component	Ragulator complex
A	1903778	biological_process	protein localization to vacuolar membrane
A	1904263	biological_process	positive regulation of TORC1 signaling
A	1990131	cellular_component	Gtr1-Gtr2 GTPase complex
B	0000166	molecular_function	nucleotide binding
B	0000329	cellular_component	fungal-type vacuole membrane
B	0000785	cellular_component	chromatin
B	0003924	molecular_function	GTPase activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005770	cellular_component	late endosome
B	0005774	cellular_component	vacuolar membrane
B	0006995	biological_process	cellular response to nitrogen starvation
B	0009267	biological_process	cellular response to starvation
B	0010507	biological_process	negative regulation of autophagy
B	0016237	biological_process	microautophagy
B	0016787	molecular_function	hydrolase activity
B	0031902	cellular_component	late endosome membrane
B	0032008	biological_process	positive regulation of TOR signaling
B	0032456	biological_process	endocytic recycling
B	0034599	biological_process	cellular response to oxidative stress
B	0045121	cellular_component	membrane raft
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0071230	biological_process	cellular response to amino acid stimulus
B	0071986	cellular_component	Ragulator complex
B	1903778	biological_process	protein localization to vacuolar membrane
B	1904263	biological_process	positive regulation of TORC1 signaling
B	1990131	cellular_component	Gtr1-Gtr2 GTPase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE GTP A 400

Chain	Residue
A	SER15
A	GLY63
A	GLY64
A	HIS126
A	LYS127
A	ASP129
A	LEU130
A	SER165
A	ILE166
A	MG500
A	GLY16
A	SER17
A	GLY18
A	LYS19
A	SER20
A	SER21
A	ALA40
A	THR41

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site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 500

Chain	Residue
A	SER20
A	THR41
A	GTP400

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site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GDP B 400

Chain	Residue
B	ARG19
B	CYS20
B	GLY21
B	LYS22
B	SER23
B	SER24
B	HIS124
B	LYS125
B	ASP127
B	SER165
B	ILE166
B	PHE167

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21816923","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3R7W","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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