4ARE

Crystal structure of the collagenase Unit of collagenase G from Clostridium histolyticum at 2.19 angstrom resolution.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0005576	cellular_component	extracellular region
A	0006508	biological_process	proteolysis
A	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN A 1790

Chain	Residue
A	HIS523
A	GLU524
A	HIS527
A	GLU555
A	HOH2168
A	HOH2169

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site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE P6G A 1791

Chain	Residue
A	TRP337
A	ASP340
A	TYR344
A	HOH2267
A	PRO278
A	ASP279
A	TYR280

---

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE FLC A 1792

Chain	Residue
A	SER568
A	VAL570
A	TYR618
A	GLU619
A	MET622
A	TRP736
A	ASP737
A	LYS741
A	HOH2117
A	HOH2196
A	HOH2251

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE TRS A 1793

Chain	Residue
A	TYR344
A	LYS348
A	ARG382
A	TRP385
A	HOH2269

---

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. LFRHEYTHYL

Chain	Residue	Details
A	LEU520-LEU529

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000305|PubMed:11121400

Chain	Residue	Details
A	GLU524

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q899Y1, ECO:0000303|PubMed:23703618

Chain	Residue	Details
A	GLU498
A	ALA531
A	VAL535
A	GLY537

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:21947205, ECO:0000269|PubMed:23703618, ECO:0007744|PDB:2Y50, ECO:0007744|PDB:2Y6I, ECO:0007744|PDB:4ARE

Chain	Residue	Details
A	HIS523
A	HIS527

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:21947205, ECO:0000269|PubMed:23703618, ECO:0007744|PDB:2Y50, ECO:0007744|PDB:2Y6I, ECO:0007744|PDB:4ARE

Chain	Residue	Details
A	GLU555

---