4AR1

Crystal Structure of the Peptidase Domain of Collagenase H from Clostridium histolyticum at 2.01 Angstrom resolution.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0005576	cellular_component	extracellular region
A	0006508	biological_process	proteolysis
A	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1722

Chain	Residue
A	ASP421
A	HIS455
A	HIS459
A	GLU487

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 1723

Chain	Residue
A	HOH2058
A	GLU430
A	GLY463
A	VAL467
A	GLY469
A	HOH2041

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Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. LFRHEYTHYL

Chain	Residue	Details
A	LEU452-LEU461

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	112
Details	Region: {"description":"Helper subdomain","evidences":[{"source":"PubMed","id":"23703618","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"9452493","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23703618","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4AR1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23703618","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28820255","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4AR1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ARF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O7E","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23703618","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28820255","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10217773","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4AR1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ARF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O7E","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23703618","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28820255","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10217773","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4AR1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ARF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O7E","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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