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4AQ5

Gating movement in acetylcholine receptor analysed by time-resolved electron cryo-microscopy (closed class)

Functional Information from GO Data
ChainGOidnamespacecontents
A0004888molecular_functiontransmembrane signaling receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
A0006811biological_processmonoatomic ion transport
A0016020cellular_componentmembrane
A0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
A0034220biological_processmonoatomic ion transmembrane transport
A0045211cellular_componentpostsynaptic membrane
B0004888molecular_functiontransmembrane signaling receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
B0006811biological_processmonoatomic ion transport
B0016020cellular_componentmembrane
B0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
B0034220biological_processmonoatomic ion transmembrane transport
B0045211cellular_componentpostsynaptic membrane
C0004888molecular_functiontransmembrane signaling receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
C0006811biological_processmonoatomic ion transport
C0016020cellular_componentmembrane
C0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
C0034220biological_processmonoatomic ion transmembrane transport
C0045211cellular_componentpostsynaptic membrane
D0004888molecular_functiontransmembrane signaling receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
D0006811biological_processmonoatomic ion transport
D0016020cellular_componentmembrane
D0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
D0034220biological_processmonoatomic ion transmembrane transport
D0045211cellular_componentpostsynaptic membrane
E0004888molecular_functiontransmembrane signaling receptor activity
E0005216molecular_functionmonoatomic ion channel activity
E0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
E0005886cellular_componentplasma membrane
E0005892cellular_componentacetylcholine-gated channel complex
E0006811biological_processmonoatomic ion transport
E0007165biological_processsignal transduction
E0007268biological_processchemical synaptic transmission
E0016020cellular_componentmembrane
E0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
E0034220biological_processmonoatomic ion transmembrane transport
E0042391biological_processregulation of membrane potential
E0043005cellular_componentneuron projection
E0045202cellular_componentsynapse
E0045211cellular_componentpostsynaptic membrane
E0050877biological_processnervous system process
E0060078biological_processregulation of postsynaptic membrane potential
E0060079biological_processexcitatory postsynaptic potential
E0095500biological_processacetylcholine receptor signaling pathway
Functional Information from PROSITE/UniProt
site_idPS00236
Number of Residues15
DetailsNEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CpIaVtyFPfDwqnC
ChainResidueDetails
ECYS127-CYS141
CCYS130-CYS144
BCYS128-CYS142
ACYS128-CYS142

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues418
DetailsTOPO_DOM: Extracellular
ChainResidueDetails
ASER1-ILE210
DSER1-ILE210

site_idSWS_FT_FI2
Number of Residues158
DetailsTRANSMEM: Helical
ChainResidueDetails
APRO211-LEU235
AMET243-VAL261
ATYR277-ILE296
AILE409-ALA427
DPRO211-LEU235
DMET243-VAL261
DTYR277-ILE296
DILE409-ALA427

site_idSWS_FT_FI3
Number of Residues222
DetailsTOPO_DOM: Cytoplasmic
ChainResidueDetails
AASN297-HIS408
DASN297-HIS408

site_idSWS_FT_FI4
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN141
DASN141

226707

PDB entries from 2024-10-30

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