Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4AQ2

resting state of homogentisate 1,2-dioxygenase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0001217	molecular_function	DNA-binding transcription repressor activity
A	0004411	molecular_function	homogentisate 1,2-dioxygenase activity
A	0005506	molecular_function	iron ion binding
A	0005737	cellular_component	cytoplasm
A	0006559	biological_process	L-phenylalanine catabolic process
A	0006570	biological_process	tyrosine metabolic process
A	0006572	biological_process	L-tyrosine catabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0032993	cellular_component	protein-DNA complex
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0046872	molecular_function	metal ion binding
A	0051213	molecular_function	dioxygenase activity
B	0000976	molecular_function	transcription cis-regulatory region binding
B	0001217	molecular_function	DNA-binding transcription repressor activity
B	0004411	molecular_function	homogentisate 1,2-dioxygenase activity
B	0005506	molecular_function	iron ion binding
B	0005737	cellular_component	cytoplasm
B	0006559	biological_process	L-phenylalanine catabolic process
B	0006570	biological_process	tyrosine metabolic process
B	0006572	biological_process	L-tyrosine catabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0032993	cellular_component	protein-DNA complex
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0046872	molecular_function	metal ion binding
B	0051213	molecular_function	dioxygenase activity
C	0000976	molecular_function	transcription cis-regulatory region binding
C	0001217	molecular_function	DNA-binding transcription repressor activity
C	0004411	molecular_function	homogentisate 1,2-dioxygenase activity
C	0005506	molecular_function	iron ion binding
C	0005737	cellular_component	cytoplasm
C	0006559	biological_process	L-phenylalanine catabolic process
C	0006570	biological_process	tyrosine metabolic process
C	0006572	biological_process	L-tyrosine catabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0032993	cellular_component	protein-DNA complex
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0046872	molecular_function	metal ion binding
C	0051213	molecular_function	dioxygenase activity
D	0000976	molecular_function	transcription cis-regulatory region binding
D	0001217	molecular_function	DNA-binding transcription repressor activity
D	0004411	molecular_function	homogentisate 1,2-dioxygenase activity
D	0005506	molecular_function	iron ion binding
D	0005737	cellular_component	cytoplasm
D	0006559	biological_process	L-phenylalanine catabolic process
D	0006570	biological_process	tyrosine metabolic process
D	0006572	biological_process	L-tyrosine catabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0032993	cellular_component	protein-DNA complex
D	0045892	biological_process	negative regulation of DNA-templated transcription
D	0046872	molecular_function	metal ion binding
D	0051213	molecular_function	dioxygenase activity
E	0000976	molecular_function	transcription cis-regulatory region binding
E	0001217	molecular_function	DNA-binding transcription repressor activity
E	0004411	molecular_function	homogentisate 1,2-dioxygenase activity
E	0005506	molecular_function	iron ion binding
E	0005737	cellular_component	cytoplasm
E	0006559	biological_process	L-phenylalanine catabolic process
E	0006570	biological_process	tyrosine metabolic process
E	0006572	biological_process	L-tyrosine catabolic process
E	0016491	molecular_function	oxidoreductase activity
E	0032993	cellular_component	protein-DNA complex
E	0045892	biological_process	negative regulation of DNA-templated transcription
E	0046872	molecular_function	metal ion binding
E	0051213	molecular_function	dioxygenase activity
F	0000976	molecular_function	transcription cis-regulatory region binding
F	0001217	molecular_function	DNA-binding transcription repressor activity
F	0004411	molecular_function	homogentisate 1,2-dioxygenase activity
F	0005506	molecular_function	iron ion binding
F	0005737	cellular_component	cytoplasm
F	0006559	biological_process	L-phenylalanine catabolic process
F	0006570	biological_process	tyrosine metabolic process
F	0006572	biological_process	L-tyrosine catabolic process
F	0016491	molecular_function	oxidoreductase activity
F	0032993	cellular_component	protein-DNA complex
F	0045892	biological_process	negative regulation of DNA-templated transcription
F	0046872	molecular_function	metal ion binding
F	0051213	molecular_function	dioxygenase activity
G	0000976	molecular_function	transcription cis-regulatory region binding
G	0001217	molecular_function	DNA-binding transcription repressor activity
G	0004411	molecular_function	homogentisate 1,2-dioxygenase activity
G	0005506	molecular_function	iron ion binding
G	0005737	cellular_component	cytoplasm
G	0006559	biological_process	L-phenylalanine catabolic process
G	0006570	biological_process	tyrosine metabolic process
G	0006572	biological_process	L-tyrosine catabolic process
G	0016491	molecular_function	oxidoreductase activity
G	0032993	cellular_component	protein-DNA complex
G	0045892	biological_process	negative regulation of DNA-templated transcription
G	0046872	molecular_function	metal ion binding
G	0051213	molecular_function	dioxygenase activity
H	0000976	molecular_function	transcription cis-regulatory region binding
H	0001217	molecular_function	DNA-binding transcription repressor activity
H	0004411	molecular_function	homogentisate 1,2-dioxygenase activity
H	0005506	molecular_function	iron ion binding
H	0005737	cellular_component	cytoplasm
H	0006559	biological_process	L-phenylalanine catabolic process
H	0006570	biological_process	tyrosine metabolic process
H	0006572	biological_process	L-tyrosine catabolic process
H	0016491	molecular_function	oxidoreductase activity
H	0032993	cellular_component	protein-DNA complex
H	0045892	biological_process	negative regulation of DNA-templated transcription
H	0046872	molecular_function	metal ion binding
H	0051213	molecular_function	dioxygenase activity
I	0000976	molecular_function	transcription cis-regulatory region binding
I	0001217	molecular_function	DNA-binding transcription repressor activity
I	0004411	molecular_function	homogentisate 1,2-dioxygenase activity
I	0005506	molecular_function	iron ion binding
I	0005737	cellular_component	cytoplasm
I	0006559	biological_process	L-phenylalanine catabolic process
I	0006570	biological_process	tyrosine metabolic process
I	0006572	biological_process	L-tyrosine catabolic process
I	0016491	molecular_function	oxidoreductase activity
I	0032993	cellular_component	protein-DNA complex
I	0045892	biological_process	negative regulation of DNA-templated transcription
I	0046872	molecular_function	metal ion binding
I	0051213	molecular_function	dioxygenase activity
J	0000976	molecular_function	transcription cis-regulatory region binding
J	0001217	molecular_function	DNA-binding transcription repressor activity
J	0004411	molecular_function	homogentisate 1,2-dioxygenase activity
J	0005506	molecular_function	iron ion binding
J	0005737	cellular_component	cytoplasm
J	0006559	biological_process	L-phenylalanine catabolic process
J	0006570	biological_process	tyrosine metabolic process
J	0006572	biological_process	L-tyrosine catabolic process
J	0016491	molecular_function	oxidoreductase activity
J	0032993	cellular_component	protein-DNA complex
J	0045892	biological_process	negative regulation of DNA-templated transcription
J	0046872	molecular_function	metal ion binding
J	0051213	molecular_function	dioxygenase activity
K	0000976	molecular_function	transcription cis-regulatory region binding
K	0001217	molecular_function	DNA-binding transcription repressor activity
K	0004411	molecular_function	homogentisate 1,2-dioxygenase activity
K	0005506	molecular_function	iron ion binding
K	0005737	cellular_component	cytoplasm
K	0006559	biological_process	L-phenylalanine catabolic process
K	0006570	biological_process	tyrosine metabolic process
K	0006572	biological_process	L-tyrosine catabolic process
K	0016491	molecular_function	oxidoreductase activity
K	0032993	cellular_component	protein-DNA complex
K	0045892	biological_process	negative regulation of DNA-templated transcription
K	0046872	molecular_function	metal ion binding
K	0051213	molecular_function	dioxygenase activity
L	0000976	molecular_function	transcription cis-regulatory region binding
L	0001217	molecular_function	DNA-binding transcription repressor activity
L	0004411	molecular_function	homogentisate 1,2-dioxygenase activity
L	0005506	molecular_function	iron ion binding
L	0005737	cellular_component	cytoplasm
L	0006559	biological_process	L-phenylalanine catabolic process
L	0006570	biological_process	tyrosine metabolic process
L	0006572	biological_process	L-tyrosine catabolic process
L	0016491	molecular_function	oxidoreductase activity
L	0032993	cellular_component	protein-DNA complex
L	0045892	biological_process	negative regulation of DNA-templated transcription
L	0046872	molecular_function	metal ion binding
L	0051213	molecular_function	dioxygenase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE A 800

Chain	Residue
A	HIS331
A	GLU337
A	HIS367
A	HOH2432
A	HOH2433

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE B 800

Chain	Residue
B	HOH2426
B	HIS331
B	GLU337
B	HIS367
B	HOH2425

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE C 800

Chain	Residue
C	HIS331
C	GLU337
C	HIS367
C	HOH2391
C	HOH2392

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE D 800

Chain	Residue
D	HIS331
D	GLU337
D	HIS367
D	HOH2399
D	HOH2400

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE E 800

Chain	Residue
E	HIS331
E	GLU337
E	HIS367
E	HOH2403
E	HOH2404

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE F 800

Chain	Residue
F	HIS331
F	GLU337
F	HIS367
F	HOH2363
F	HOH2364

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE G 800

Chain	Residue
G	HIS331
G	GLU337
G	HIS367
G	HOH2392
G	HOH2393

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE H 800

Chain	Residue
H	HIS331
H	GLU337
H	HIS367
H	HOH2429
H	HOH2430

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE I 800

Chain	Residue
I	HIS331
I	GLU337
I	HIS367
I	HOH2376
I	HOH2377

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE J 800

Chain	Residue
J	HIS331
J	GLU337
J	HIS367
J	HOH2380
J	HOH2381

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE K 800

Chain	Residue
K	HIS331
K	GLU337
K	HIS367
K	HOH2362
K	HOH2363

site_id	BC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE B3P K 1434

Chain	Residue
A	GLU77
A	ARG78
A	HOH2163
A	HOH2164
K	GLU141
K	ARG142
K	GLN240
K	HOH2180
K	HOH2184
K	HOH2222
K	HOH2226

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE L 800

Chain	Residue
L	HIS331
L	GLU337
L	HIS367
L	HOH2337
L	HOH2338

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00334","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23858455","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	24
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00334","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23858455","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)