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4AOW

Crystal structure of the human Rack1 protein at a resolution of 2.45 angstrom

Functional Information from GO Data
ChainGOidnamespacecontents
A0001891cellular_componentphagocytic cup
A0001934biological_processpositive regulation of protein phosphorylation
A0002181biological_processcytoplasmic translation
A0003723molecular_functionRNA binding
A0005080molecular_functionprotein kinase C binding
A0005102molecular_functionsignaling receptor binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0005840cellular_componentribosome
A0005886cellular_componentplasma membrane
A0006412biological_processtranslation
A0006417biological_processregulation of translation
A0006915biological_processapoptotic process
A0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
A0007369biological_processgastrulation
A0008047molecular_functionenzyme activator activity
A0008200molecular_functionion channel inhibitor activity
A0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
A0010629biological_processnegative regulation of gene expression
A0015935cellular_componentsmall ribosomal subunit
A0016567biological_processprotein ubiquitination
A0017148biological_processnegative regulation of translation
A0019899molecular_functionenzyme binding
A0019903molecular_functionprotein phosphatase binding
A0022627cellular_componentcytosolic small ribosomal subunit
A0030178biological_processnegative regulation of Wnt signaling pathway
A0030292molecular_functionprotein tyrosine kinase inhibitor activity
A0030308biological_processnegative regulation of cell growth
A0030332molecular_functioncyclin binding
A0030335biological_processpositive regulation of cell migration
A0030425cellular_componentdendrite
A0030496cellular_componentmidbody
A0030971molecular_functionreceptor tyrosine kinase binding
A0031334biological_processpositive regulation of protein-containing complex assembly
A0032091biological_processnegative regulation of protein binding
A0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
A0032880biological_processregulation of protein localization
A0033137biological_processnegative regulation of peptidyl-serine phosphorylation
A0035591molecular_functionsignaling adaptor activity
A0042169molecular_functionSH2 domain binding
A0042803molecular_functionprotein homodimerization activity
A0042995cellular_componentcell projection
A0042998biological_processpositive regulation of Golgi to plasma membrane protein transport
A0043005cellular_componentneuron projection
A0043022molecular_functionribosome binding
A0043025cellular_componentneuronal cell body
A0043065biological_processpositive regulation of apoptotic process
A0043204cellular_componentperikaryon
A0043473biological_processpigmentation
A0043547biological_processpositive regulation of GTPase activity
A0044297cellular_componentcell body
A0045182molecular_functiontranslation regulator activity
A0045296molecular_functioncadherin binding
A0045879biological_processnegative regulation of smoothened signaling pathway
A0048471cellular_componentperinuclear region of cytoplasm
A0048511biological_processrhythmic process
A0050765biological_processnegative regulation of phagocytosis
A0051302biological_processregulation of cell division
A0051434molecular_functionBH3 domain binding
A0051726biological_processregulation of cell cycle
A0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0051901biological_processpositive regulation of mitochondrial depolarization
A0060090molecular_functionmolecular adaptor activity
A0070062cellular_componentextracellular exosome
A0071333biological_processcellular response to glucose stimulus
A0071363biological_processcellular response to growth factor stimulus
A0072344biological_processrescue of stalled ribosome
A0106070biological_processregulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
A1900102biological_processnegative regulation of endoplasmic reticulum unfolded protein response
A1903751biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
A1990630cellular_componentIRE1-RACK1-PP2A complex
A1990904cellular_componentribonucleoprotein complex
A2000114biological_processregulation of establishment of cell polarity
A2000543biological_processpositive regulation of gastrulation
A2001244biological_processpositive regulation of intrinsic apoptotic signaling pathway
B0001891cellular_componentphagocytic cup
B0001934biological_processpositive regulation of protein phosphorylation
B0002181biological_processcytoplasmic translation
B0003723molecular_functionRNA binding
B0005080molecular_functionprotein kinase C binding
B0005102molecular_functionsignaling receptor binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0005840cellular_componentribosome
B0005886cellular_componentplasma membrane
B0006412biological_processtranslation
B0006417biological_processregulation of translation
B0006915biological_processapoptotic process
B0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
B0007369biological_processgastrulation
B0008047molecular_functionenzyme activator activity
B0008200molecular_functionion channel inhibitor activity
B0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
B0010629biological_processnegative regulation of gene expression
B0015935cellular_componentsmall ribosomal subunit
B0016567biological_processprotein ubiquitination
B0017148biological_processnegative regulation of translation
B0019899molecular_functionenzyme binding
B0019903molecular_functionprotein phosphatase binding
B0022627cellular_componentcytosolic small ribosomal subunit
B0030178biological_processnegative regulation of Wnt signaling pathway
B0030292molecular_functionprotein tyrosine kinase inhibitor activity
B0030308biological_processnegative regulation of cell growth
B0030332molecular_functioncyclin binding
B0030335biological_processpositive regulation of cell migration
B0030425cellular_componentdendrite
B0030496cellular_componentmidbody
B0030971molecular_functionreceptor tyrosine kinase binding
B0031334biological_processpositive regulation of protein-containing complex assembly
B0032091biological_processnegative regulation of protein binding
B0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
B0032880biological_processregulation of protein localization
B0033137biological_processnegative regulation of peptidyl-serine phosphorylation
B0035591molecular_functionsignaling adaptor activity
B0042169molecular_functionSH2 domain binding
B0042803molecular_functionprotein homodimerization activity
B0042995cellular_componentcell projection
B0042998biological_processpositive regulation of Golgi to plasma membrane protein transport
B0043005cellular_componentneuron projection
B0043022molecular_functionribosome binding
B0043025cellular_componentneuronal cell body
B0043065biological_processpositive regulation of apoptotic process
B0043204cellular_componentperikaryon
B0043473biological_processpigmentation
B0043547biological_processpositive regulation of GTPase activity
B0044297cellular_componentcell body
B0045182molecular_functiontranslation regulator activity
B0045296molecular_functioncadherin binding
B0045879biological_processnegative regulation of smoothened signaling pathway
B0048471cellular_componentperinuclear region of cytoplasm
B0048511biological_processrhythmic process
B0050765biological_processnegative regulation of phagocytosis
B0051302biological_processregulation of cell division
B0051434molecular_functionBH3 domain binding
B0051726biological_processregulation of cell cycle
B0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0051901biological_processpositive regulation of mitochondrial depolarization
B0060090molecular_functionmolecular adaptor activity
B0070062cellular_componentextracellular exosome
B0071333biological_processcellular response to glucose stimulus
B0071363biological_processcellular response to growth factor stimulus
B0072344biological_processrescue of stalled ribosome
B0106070biological_processregulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
B1900102biological_processnegative regulation of endoplasmic reticulum unfolded protein response
B1903751biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
B1990630cellular_componentIRE1-RACK1-PP2A complex
B1990904cellular_componentribonucleoprotein complex
B2000114biological_processregulation of establishment of cell polarity
B2000543biological_processpositive regulation of gastrulation
B2001244biological_processpositive regulation of intrinsic apoptotic signaling pathway
C0001891cellular_componentphagocytic cup
C0001934biological_processpositive regulation of protein phosphorylation
C0002181biological_processcytoplasmic translation
C0003723molecular_functionRNA binding
C0005080molecular_functionprotein kinase C binding
C0005102molecular_functionsignaling receptor binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005829cellular_componentcytosol
C0005840cellular_componentribosome
C0005886cellular_componentplasma membrane
C0006412biological_processtranslation
C0006417biological_processregulation of translation
C0006915biological_processapoptotic process
C0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
C0007369biological_processgastrulation
C0008047molecular_functionenzyme activator activity
C0008200molecular_functionion channel inhibitor activity
C0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
C0010629biological_processnegative regulation of gene expression
C0015935cellular_componentsmall ribosomal subunit
C0016567biological_processprotein ubiquitination
C0017148biological_processnegative regulation of translation
C0019899molecular_functionenzyme binding
C0019903molecular_functionprotein phosphatase binding
C0022627cellular_componentcytosolic small ribosomal subunit
C0030178biological_processnegative regulation of Wnt signaling pathway
C0030292molecular_functionprotein tyrosine kinase inhibitor activity
C0030308biological_processnegative regulation of cell growth
C0030332molecular_functioncyclin binding
C0030335biological_processpositive regulation of cell migration
C0030425cellular_componentdendrite
C0030496cellular_componentmidbody
C0030971molecular_functionreceptor tyrosine kinase binding
C0031334biological_processpositive regulation of protein-containing complex assembly
C0032091biological_processnegative regulation of protein binding
C0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
C0032880biological_processregulation of protein localization
C0033137biological_processnegative regulation of peptidyl-serine phosphorylation
C0035591molecular_functionsignaling adaptor activity
C0042169molecular_functionSH2 domain binding
C0042803molecular_functionprotein homodimerization activity
C0042995cellular_componentcell projection
C0042998biological_processpositive regulation of Golgi to plasma membrane protein transport
C0043005cellular_componentneuron projection
C0043022molecular_functionribosome binding
C0043025cellular_componentneuronal cell body
C0043065biological_processpositive regulation of apoptotic process
C0043204cellular_componentperikaryon
C0043473biological_processpigmentation
C0043547biological_processpositive regulation of GTPase activity
C0044297cellular_componentcell body
C0045182molecular_functiontranslation regulator activity
C0045296molecular_functioncadherin binding
C0045879biological_processnegative regulation of smoothened signaling pathway
C0048471cellular_componentperinuclear region of cytoplasm
C0048511biological_processrhythmic process
C0050765biological_processnegative regulation of phagocytosis
C0051302biological_processregulation of cell division
C0051434molecular_functionBH3 domain binding
C0051726biological_processregulation of cell cycle
C0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C0051901biological_processpositive regulation of mitochondrial depolarization
C0060090molecular_functionmolecular adaptor activity
C0070062cellular_componentextracellular exosome
C0071333biological_processcellular response to glucose stimulus
C0071363biological_processcellular response to growth factor stimulus
C0072344biological_processrescue of stalled ribosome
C0106070biological_processregulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
C1900102biological_processnegative regulation of endoplasmic reticulum unfolded protein response
C1903751biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
C1990630cellular_componentIRE1-RACK1-PP2A complex
C1990904cellular_componentribonucleoprotein complex
C2000114biological_processregulation of establishment of cell polarity
C2000543biological_processpositive regulation of gastrulation
C2001244biological_processpositive regulation of intrinsic apoptotic signaling pathway
Functional Information from PDB Data
site_idAC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL B 1315
ChainResidue
BTRP83
BASP84
BGLY85
BLYS106
BASP107
CPRO243
CALA293

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL B 1316
ChainResidue
BALA112
BPHE113
BARG155
BPHE156
BVAL70
BVAL111

Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. ALSGswDgTLRLWDL
ChainResidueDetails
AALA78-LEU92
AILE120-THR134
AILE165-LEU179
ACYS207-LEU221

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsMOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378
ChainResidueDetails
AMET1
BMET1
CMET1

site_idSWS_FT_FI2
Number of Residues3
DetailsMOD_RES: N-acetylthreonine; in Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed => ECO:0000269|Ref.9, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378
ChainResidueDetails
ATHR2
BTHR2
CTHR2

site_idSWS_FT_FI3
Number of Residues9
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
CTHR6
CTHR10
CTHR96
ATHR6
ATHR10
ATHR96
BTHR6
BTHR10
BTHR96

site_idSWS_FT_FI4
Number of Residues3
DetailsMOD_RES: Phosphotyrosine; by ABL1 => ECO:0000305|PubMed:19423701
ChainResidueDetails
ATYR52
BTYR52
CTYR52

site_idSWS_FT_FI5
Number of Residues3
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
CLYS130
ALYS130
BLYS130

site_idSWS_FT_FI6
Number of Residues3
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P68040
ChainResidueDetails
CLYS183
ALYS183
BLYS183

site_idSWS_FT_FI7
Number of Residues3
DetailsMOD_RES: Phosphotyrosine => ECO:0000269|PubMed:11279199
ChainResidueDetails
CTYR228
ATYR228
BTYR228

site_idSWS_FT_FI8
Number of Residues3
DetailsMOD_RES: Phosphoserine; by viral VacV B1 kinase => ECO:0000269|PubMed:28636603, ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER276
CSER276
ASER276

site_idSWS_FT_FI9
Number of Residues3
DetailsMOD_RES: Phosphothreonine; by viral VacV B1 kinase => ECO:0000269|PubMed:28636603
ChainResidueDetails
ATHR277
BTHR277
CTHR277

site_idSWS_FT_FI10
Number of Residues6
DetailsMOD_RES: Phosphoserine; by viral VacV B1 kinase => ECO:0000269|PubMed:28636603
ChainResidueDetails
ASER278
ASER279
BSER278
BSER279
CSER278
CSER279

site_idSWS_FT_FI11
Number of Residues3
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P68040
ChainResidueDetails
ATHR316
BTHR316
CTHR316

221051

PDB entries from 2024-06-12

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