4AOR
Cationic trypsin in complex with the Spinacia oleracea trypsin inhibitor III (SOTI-III)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004175 | molecular_function | endopeptidase activity |
A | 0004252 | molecular_function | serine-type endopeptidase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005576 | cellular_component | extracellular region |
A | 0005615 | cellular_component | extracellular space |
A | 0006508 | biological_process | proteolysis |
A | 0007586 | biological_process | digestion |
A | 0008236 | molecular_function | serine-type peptidase activity |
A | 0046872 | molecular_function | metal ion binding |
A | 0097180 | cellular_component | serine protease inhibitor complex |
A | 0097655 | molecular_function | serpin family protein binding |
B | 0004175 | molecular_function | endopeptidase activity |
B | 0004252 | molecular_function | serine-type endopeptidase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005576 | cellular_component | extracellular region |
B | 0005615 | cellular_component | extracellular space |
B | 0006508 | biological_process | proteolysis |
B | 0007586 | biological_process | digestion |
B | 0008236 | molecular_function | serine-type peptidase activity |
B | 0046872 | molecular_function | metal ion binding |
B | 0097180 | cellular_component | serine protease inhibitor complex |
B | 0097655 | molecular_function | serpin family protein binding |
C | 0004175 | molecular_function | endopeptidase activity |
C | 0004252 | molecular_function | serine-type endopeptidase activity |
C | 0005515 | molecular_function | protein binding |
C | 0005576 | cellular_component | extracellular region |
C | 0005615 | cellular_component | extracellular space |
C | 0006508 | biological_process | proteolysis |
C | 0007586 | biological_process | digestion |
C | 0008236 | molecular_function | serine-type peptidase activity |
C | 0046872 | molecular_function | metal ion binding |
C | 0097180 | cellular_component | serine protease inhibitor complex |
C | 0097655 | molecular_function | serpin family protein binding |
D | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
D | 0010466 | biological_process | negative regulation of peptidase activity |
E | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
E | 0010466 | biological_process | negative regulation of peptidase activity |
F | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
F | 0010466 | biological_process | negative regulation of peptidase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE GOL A 1247 |
Chain | Residue |
A | LYS66 |
A | SER67 |
A | GLY68 |
A | ILE69 |
A | ALA90 |
A | SER93 |
A | HOH2063 |
A | HOH2210 |
B | SER134 |
site_id | AC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL A 1248 |
Chain | Residue |
A | GLN138 |
A | LEU140 |
A | VAL205 |
A | CYS206 |
A | SER207 |
A | GLY208 |
A | HOH2211 |
E | HOH2014 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL A 1249 |
Chain | Residue |
A | GLN138 |
A | PRO164 |
A | TYR188 |
A | HOH2178 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL A 1250 |
Chain | Residue |
A | HIS96 |
A | ASN106 |
A | ASN182 |
A | TYR235 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CL A 1251 |
Chain | Residue |
A | ARG72 |
A | GLU75 |
A | ILE78 |
A | HOH2029 |
site_id | AC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL A 1252 |
Chain | Residue |
A | ASN100 |
A | ASN105 |
A | HOH2105 |
site_id | AC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE IMD A 1253 |
Chain | Residue |
A | ASN42 |
A | TYR45 |
A | HIS46 |
A | ILE78 |
A | ASN79 |
D | PHE14 |
site_id | AC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE IMD A 1254 |
Chain | Residue |
A | ASN102 |
A | THR103 |
A | GLN178 |
A | TRP216 |
A | HOH2104 |
C | PHE87 |
site_id | AC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 1255 |
Chain | Residue |
A | GLU75 |
A | ASN77 |
A | VAL80 |
A | GLU85 |
A | HOH2068 |
A | HOH2069 |
site_id | BC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL B 1247 |
Chain | Residue |
B | TYR175 |
B | GLN178 |
B | SER218 |
B | IMD1250 |
E | ILE30 |
site_id | BC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE IMD B 1248 |
Chain | Residue |
B | LYS66 |
B | GLY68 |
B | ILE69 |
B | ALA90 |
B | SER93 |
site_id | BC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE IMD B 1249 |
Chain | Residue |
B | TYR45 |
B | HIS46 |
B | ILE78 |
B | ASN79 |
site_id | BC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE IMD B 1250 |
Chain | Residue |
B | ASN102 |
B | THR103 |
B | GLN178 |
B | GOL1247 |
B | IMD1251 |
B | HOH2089 |
site_id | BC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE IMD B 1251 |
Chain | Residue |
B | SER101 |
B | ASN102 |
B | IMD1250 |
E | HIS28 |
site_id | BC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA B 1252 |
Chain | Residue |
B | GLU75 |
B | ASN77 |
B | VAL80 |
B | GLU85 |
B | HOH2059 |
B | HOH2060 |
site_id | BC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CA B 1253 |
Chain | Residue |
B | SER170 |
B | HOH2141 |
B | HOH2187 |
site_id | BC8 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE MES B 1254 |
Chain | Residue |
A | PRO129 |
A | THR130 |
A | SER131 |
A | CYS233 |
A | VAL236 |
A | SER237 |
A | LYS240 |
A | HOH2197 |
B | SER237 |
B | TRP238 |
B | GLN241 |
B | HOH2082 |
B | HOH2177 |
site_id | BC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL C 1247 |
Chain | Residue |
C | TRP216 |
C | ASN102 |
C | THR103 |
C | GLN178 |
site_id | CC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE IMD C 1248 |
Chain | Residue |
C | ASN42 |
C | TYR45 |
C | HIS46 |
C | ILE78 |
C | ASN79 |
F | PHE14 |
site_id | CC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA C 1249 |
Chain | Residue |
A | HOH2172 |
C | GLU75 |
C | ASN77 |
C | VAL80 |
C | GLU85 |
C | HOH2051 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 3 |
Details | SITE: Reactive bond for trypsin => ECO:0000250|UniProtKB:P84779 |
Chain | Residue | Details |
D | ARG32 | |
E | ARG32 | |
F | ARG32 | |
B | HIS63 | |
B | ASP107 | |
B | SER200 | |
C | HIS63 | |
C | ASP107 | |
C | SER200 |
site_id | SWS_FT_FI2 |
Number of Residues | 21 |
Details | BINDING: |
Chain | Residue | Details |
A | GLU75 | |
B | VAL80 | |
B | GLU85 | |
B | ASP194 | |
B | GLN197 | |
B | SER200 | |
C | GLU75 | |
C | ASN77 | |
C | VAL80 | |
C | GLU85 | |
C | ASP194 | |
A | ASN77 | |
C | GLN197 | |
C | SER200 | |
A | VAL80 | |
A | GLU85 | |
A | ASP194 | |
A | GLN197 | |
A | SER200 | |
B | GLU75 | |
B | ASN77 |