4ANJ
MYOSIN VI (MDinsert2-GFP fusion) PRE-POWERSTROKE STATE (MG.ADP.AlF4)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003674 | molecular_function | molecular_function |
| A | 0003774 | molecular_function | cytoskeletal motor activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005575 | cellular_component | cellular_component |
| A | 0006091 | biological_process | generation of precursor metabolites and energy |
| A | 0008218 | biological_process | bioluminescence |
| A | 0016459 | cellular_component | myosin complex |
| A | 0051015 | molecular_function | actin filament binding |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005813 | cellular_component | centrosome |
| B | 0005814 | cellular_component | centriole |
| B | 0005819 | cellular_component | spindle |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0005938 | cellular_component | cell cortex |
| B | 0007099 | biological_process | centriole replication |
| B | 0007605 | biological_process | sensory perception of sound |
| B | 0007608 | biological_process | sensory perception of smell |
| B | 0016028 | cellular_component | rhabdomere |
| B | 0016056 | biological_process | G protein-coupled opsin signaling pathway |
| B | 0016059 | biological_process | negative regulation of opsin-mediated signaling pathway |
| B | 0016060 | biological_process | negative regulation of phospholipase C-activating phototransduction signaling pathway |
| B | 0016247 | molecular_function | channel regulator activity |
| B | 0030048 | biological_process | actin filament-based movement |
| B | 0030234 | molecular_function | enzyme regulator activity |
| B | 0030496 | cellular_component | midbody |
| B | 0031475 | cellular_component | myosin V complex |
| B | 0031476 | cellular_component | myosin VI complex |
| B | 0031477 | cellular_component | myosin VII complex |
| B | 0031489 | molecular_function | myosin V binding |
| B | 0032036 | molecular_function | myosin heavy chain binding |
| B | 0042052 | biological_process | rhabdomere development |
| B | 0046716 | biological_process | muscle cell cellular homeostasis |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0048102 | biological_process | autophagic cell death |
| B | 0050911 | biological_process | detection of chemical stimulus involved in sensory perception of smell |
| B | 0051383 | biological_process | kinetochore organization |
| B | 0070855 | molecular_function | myosin VI head/neck binding |
| B | 0071361 | biological_process | cellular response to ethanol |
| B | 0072499 | biological_process | photoreceptor cell axon guidance |
| B | 0072686 | cellular_component | mitotic spindle |
| B | 0097431 | cellular_component | mitotic spindle pole |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE ADP A 2230 |
| Chain | Residue |
| A | ASN98 |
| A | LYS157 |
| A | THR158 |
| A | GLU159 |
| A | PHE163 |
| A | ASN200 |
| A | HOH2022 |
| A | HOH2034 |
| A | MG2231 |
| A | ALF2232 |
| A | PRO99 |
| A | TYR100 |
| A | PHE101 |
| A | ASP102 |
| A | TYR107 |
| A | GLY154 |
| A | ALA155 |
| A | GLY156 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 2231 |
| Chain | Residue |
| A | THR158 |
| A | SER204 |
| A | HOH2034 |
| A | HOH2035 |
| A | ADP2230 |
| A | ALF2232 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE ALF A 2232 |
| Chain | Residue |
| A | SER153 |
| A | GLY154 |
| A | LYS157 |
| A | ASN200 |
| A | SER203 |
| A | SER204 |
| A | ILE457 |
| A | ALA458 |
| A | GLY459 |
| A | HOH2034 |
| A | HOH2035 |
| A | ADP2230 |
| A | MG2231 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA B 1147 |
| Chain | Residue |
| B | ASP56 |
| B | THR62 |
| B | GLU67 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA B 1148 |
| Chain | Residue |
| B | ASP95 |
| B | ASN97 |
| B | PHE99 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA B 1149 |
| Chain | Residue |
| B | ASP129 |
| B | ASP131 |
| B | GLN135 |
| B | GLU140 |
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL |
| Chain | Residue | Details |
| B | ASP20-LEU32 | |
| B | ASP56-PHE68 | |
| B | ASP93-LEU105 | |
| B | ASP129-PHE141 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 19 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 |
| Chain | Residue | Details |
| B | ASP20 | |
| B | GLU67 | |
| B | ASP93 | |
| B | ASP95 | |
| B | ASN97 | |
| B | GLU104 | |
| B | ASP129 | |
| B | ASP131 | |
| B | ASP133 | |
| B | GLN135 | |
| B | GLU140 | |
| B | ASP22 | |
| B | ASP24 | |
| B | THR26 | |
| B | GLU31 | |
| B | ASP56 | |
| B | ASP58 | |
| B | ASN60 | |
| B | THR62 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | SITE: Not N6-methylated |
| Chain | Residue | Details |
| B | LYS115 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0000250 |
| Chain | Residue | Details |
| B | ALA1 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N6,N6,N6-trimethyllysine => ECO:0000269|PubMed:17610210 |
| Chain | Residue | Details |
| B | LYS94 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: (Z)-2,3-didehydrotyrosine => ECO:0000269|PubMed:8448132 |
| Chain | Residue | Details |
| A | VAL1068 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | CROSSLNK: 5-imidazolinone (Ser-Gly) => ECO:0000269|PubMed:8448132 |
| Chain | Residue | Details |
| A | CR21065 | |
| A | GLN1069 |
