Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 1712 |
| Chain | Residue |
| A | ILE118 |
| A | LEU119 |
| A | SER120 |
| A | ASP121 |
| A | ASP446 |
| A | ASN525 |
| A | HOH2516 |
| A | HOH2613 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 1713 |
| Chain | Residue |
| A | GLU227 |
| A | PHE228 |
| A | ILE276 |
| A | LYS281 |
| A | HOH2614 |
| A | HOH2615 |
| A | ALA226 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL A 1714 |
| Chain | Residue |
| A | PRO568 |
| A | ASP569 |
| A | PHE571 |
| A | ASP627 |
| A | ILE628 |
| A | GLN629 |
| A | PRO631 |
| A | ASN668 |
| A | HOH2526 |
| A | HOH2590 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 1715 |
| Chain | Residue |
| A | GLU239 |
| A | ASP291 |
| A | TYR292 |
| A | HOH2320 |
| A | HOH2322 |
| A | HOH2376 |
| A | HOH2378 |
Functional Information from PROSITE/UniProt
| site_id | PS00708 |
| Number of Residues | 31 |
| Details | PRO_ENDOPEP_SER Prolyl endopeptidase family serine active site. DfqcAaeyLikegytspkrltinGgSnGGLL |
| Chain | Residue | Details |
| A | ASP529-LEU559 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PROSITE-ProRule","id":"PRU10084","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1900195","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Charge relay system"} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PROSITE-ProRule","id":"PRU10084","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"2064618","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"UniProtKB","id":"P48147","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P48147","evidenceCode":"ECO:0000250"}]} |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 901 |
| Chain | Residue | Details |
| A | TYR473 | electrostatic stabiliser |
| A | SER554 | covalent catalysis, proton shuttle (general acid/base) |
| A | ASP641 | electrostatic stabiliser, modifies pKa |
| A | HIS680 | proton shuttle (general acid/base) |
