4ALL
Crystal structure of S. aureus FabI in complex with NADP and triclosan (P212121)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0141148 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADPH) activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0141148 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADPH) activity |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| C | 0006633 | biological_process | fatty acid biosynthetic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0141148 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADPH) activity |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| D | 0006633 | biological_process | fatty acid biosynthetic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0141148 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADPH) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE TCL A 1257 |
| Chain | Residue |
| A | ALA95 |
| A | PHE96 |
| A | ALA97 |
| A | LEU102 |
| A | TYR147 |
| A | TYR157 |
| A | MET160 |
| A | SER197 |
| A | NAP1258 |
| site_id | AC2 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE NAP A 1258 |
| Chain | Residue |
| A | GLY13 |
| A | ILE14 |
| A | ALA15 |
| A | SER19 |
| A | ILE20 |
| A | ARG40 |
| A | LYS41 |
| A | SER44 |
| A | ILE65 |
| A | ASP66 |
| A | VAL67 |
| A | SER93 |
| A | ILE94 |
| A | ALA95 |
| A | ILE120 |
| A | THR145 |
| A | THR146 |
| A | TYR147 |
| A | LYS164 |
| A | ALA190 |
| A | GLY191 |
| A | PRO192 |
| A | ILE193 |
| A | THR195 |
| A | LEU196 |
| A | SER197 |
| A | TCL1257 |
| site_id | AC3 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE NAP B 1257 |
| Chain | Residue |
| B | GLY13 |
| B | ILE14 |
| B | ALA15 |
| B | SER19 |
| B | ILE20 |
| B | ARG40 |
| B | LYS41 |
| B | SER44 |
| B | ILE65 |
| B | ASP66 |
| B | VAL67 |
| B | SER93 |
| B | ILE94 |
| B | ALA95 |
| B | ILE120 |
| B | THR145 |
| B | THR146 |
| B | TYR147 |
| B | LYS164 |
| B | ALA190 |
| B | PRO192 |
| B | ILE193 |
| B | THR195 |
| B | SER197 |
| B | TCL1258 |
| B | HOH2001 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE TCL D 1257 |
| Chain | Residue |
| D | ALA97 |
| D | LEU102 |
| D | TYR147 |
| D | TYR157 |
| D | MET160 |
| D | SER197 |
| D | NAP1258 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE TCL B 1258 |
| Chain | Residue |
| B | ALA97 |
| B | LEU102 |
| B | TYR147 |
| B | TYR157 |
| B | MET160 |
| B | SER197 |
| B | NAP1257 |
| site_id | AC6 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE NAP C 1257 |
| Chain | Residue |
| C | GLY13 |
| C | ILE14 |
| C | ALA15 |
| C | SER19 |
| C | ILE20 |
| C | ARG40 |
| C | LYS41 |
| C | SER44 |
| C | ILE65 |
| C | ASP66 |
| C | VAL67 |
| C | SER93 |
| C | ILE94 |
| C | ALA95 |
| C | THR145 |
| C | THR146 |
| C | TYR147 |
| C | LYS164 |
| C | PRO192 |
| C | ILE193 |
| C | THR195 |
| C | SER197 |
| C | TCL1258 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE TCL C 1258 |
| Chain | Residue |
| C | ALA97 |
| C | LEU102 |
| C | TYR147 |
| C | TYR157 |
| C | MET160 |
| C | SER197 |
| C | ALA198 |
| C | VAL201 |
| C | NAP1257 |
| site_id | AC8 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE NAP D 1258 |
| Chain | Residue |
| D | GLY13 |
| D | ILE14 |
| D | ALA15 |
| D | SER19 |
| D | ILE20 |
| D | ARG40 |
| D | LYS41 |
| D | ILE65 |
| D | ASP66 |
| D | VAL67 |
| D | SER93 |
| D | ILE94 |
| D | ALA95 |
| D | ILE120 |
| D | THR145 |
| D | THR146 |
| D | TYR147 |
| D | LYS164 |
| D | PRO192 |
| D | ILE193 |
| D | THR195 |
| D | SER197 |
| D | TCL1257 |
