Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4AKO

Mutations in the neighbourhood of CotA-laccase trinuclear site: E498L mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005507	molecular_function	copper ion binding
A	0016491	molecular_function	oxidoreductase activity
A	0030288	cellular_component	outer membrane-bounded periplasmic space
A	0030435	biological_process	sporulation resulting in formation of a cellular spore
A	0046872	molecular_function	metal ion binding
A	0047705	molecular_function	bilirubin oxidase activity
A	0052716	molecular_function	hydroquinone:oxygen oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CU A 601

Chain	Residue
A	HIS419
A	CYS492
A	HIS497
A	MET502

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CU A 602

Chain	Residue
A	HIS107
A	HIS153
A	HIS493
A	OXY605

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CU A 603

Chain	Residue
A	HIS424
A	HIS491
A	OXY605
A	HIS155

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CU A 604

Chain	Residue
A	HIS105
A	HIS107
A	HIS422
A	HIS424
A	OXY605
A	HOH2189

site_id	AC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE OXY A 605

Chain	Residue
A	HIS105
A	HIS107
A	HIS153
A	HIS155
A	HIS422
A	HIS424
A	HIS491
A	HIS493
A	CU602
A	CU603
A	CU604

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1512

Chain	Residue
A	ASP113
A	TYR133
A	LYS135
A	HOH2550

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 1513

Chain	Residue
A	LYS25
A	TYR69
A	VAL138
A	THR307
A	ALA308
A	TYR309
A	GLU310
A	HOH2551

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 1514

Chain	Residue
A	ASN74
A	LEU76
A	PRO77
A	VAL100
A	SER124
A	LYS125
A	HOH2156

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1515

Chain	Residue
A	GLU188
A	GLU244
A	TYR250
A	HOH2295

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 1516

Chain	Residue
A	ARG136
A	GLU137
A	VAL138
A	PRO247
A	LEU343
A	HOH2244
A	HOH2552

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1517

Chain	Residue
A	PHE292
A	SER293
A	TYR300
A	HOH2530

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 1518

Chain	Residue
A	GLU61
A	ILE173
A	HIS175
A	ASP190
A	HOH2119
A	HOH2291
A	HOH2292
A	HOH2554

site_id	BC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 1519

Chain	Residue
A	ASP268
A	ALA317
A	PRO328
A	ALA332
A	ASN333
A	HOH2370
A	HOH2555

site_id	BC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 1520

Chain	Residue
A	LYS183
A	LEU184
A	SER186
A	GLU348
A	SER349
A	EDO1531
A	HOH2290

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 1521

Chain	Residue
A	ILE200
A	HOH2002

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1522

Chain	Residue
A	GLN362
A	ARG429
A	ALA478
A	THR480
A	HOH2446
A	HOH2502

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 1523

Chain	Residue
A	HIS37
A	GLN38

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1524

Chain	Residue
A	GLU348
A	HOH2236
A	THR130
A	GLY131
A	PHE134
A	LYS346

site_id	CC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1525

Chain	Residue
A	PRO352
A	LYS353
A	TYR354
A	ASN390
A	HOH2438
A	HOH2462

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1526

Chain	Residue
A	ASN75
A	LYS125
A	GLN367
A	LYS402
A	HOH2456

site_id	CC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1527

Chain	Residue
A	ARG64
A	ARG146
A	HOH2129
A	HOH2258
A	HOH2440
A	HOH2442

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1528

Chain	Residue
A	ASN269
A	GLY271
A	ASP272
A	ILE304
A	ASP305
A	TYR309

site_id	CC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1529

Chain	Residue
A	TYR354
A	LEU355
A	ALA356
A	THR377
A	HOH2384

site_id	CC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 1530

Chain	Residue
A	PHE81
A	LEU206
A	PHE207
A	TYR208
A	HOH2160
A	HOH2311
A	HOH2321

site_id	CC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1531

Chain	Residue
A	ASP187
A	TYR189
A	GLN345
A	EDO1520
A	HOH2294
A	HOH2351

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	Domain: {"description":"Plastocyanin-like 1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	77
Details	Domain: {"description":"Plastocyanin-like 2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	78
Details	Domain: {"description":"Plastocyanin-like 3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"description":"type 2 copper site","evidences":[{"source":"PubMed","id":"12637519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14764581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16234932","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20822511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1GSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OF0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W6W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W8E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BHF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2X87","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2X88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZDW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	6
Details	Binding site: {"description":"type 3 copper site","evidences":[{"source":"PubMed","id":"12637519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14764581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16234932","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20822511","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27050268","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1GSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OF0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W6W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W8E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BHF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2X87","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2X88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZDW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YVN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YVU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	3
Details	Binding site: {"description":"type 1 copper site","evidences":[{"source":"PubMed","id":"12637519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14764581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16234932","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20822511","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27050268","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1GSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OF0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W6W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W8E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BHF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2X87","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2X88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZDW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YVN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YVU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"description":"type 1 copper site","evidences":[{"source":"PubMed","id":"12637519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16234932","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20822511","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27050268","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1GSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OF0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W8E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BHF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2X87","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2X88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YVN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YVU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	1
Details	Site: {"description":"Plays a crucial role in the protonation steps","evidences":[{"source":"PubMed","id":"22481612","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	1
Details	Site: {"description":"Plays a crucial role in the protonation steps","evidences":[{"source":"PubMed","id":"20200715","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"20822511","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22481612","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)