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4AJL

rat LDHA in complex with 3-(ethylcarbamoylamino)-N-(2-methyl-1,3- benzothiazol-6-yl)propanamide

Functional Information from GO Data
ChainGOidnamespacecontents
A0001666biological_processresponse to hypoxia
A0001889biological_processliver development
A0003824molecular_functioncatalytic activity
A0004457molecular_functionlactate dehydrogenase activity
A0004459molecular_functionL-lactate dehydrogenase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0006089biological_processlactate metabolic process
A0006090biological_processpyruvate metabolic process
A0007519biological_processskeletal muscle tissue development
A0007584biological_processresponse to nutrient
A0009410biological_processresponse to xenobiotic stimulus
A0009749biological_processresponse to glucose
A0014070biological_processresponse to organic cyclic compound
A0016491molecular_functionoxidoreductase activity
A0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A0019661biological_processglucose catabolic process to lactate via pyruvate
A0019674biological_processNAD metabolic process
A0019752biological_processcarboxylic acid metabolic process
A0019900molecular_functionkinase binding
A0031668biological_processcellular response to extracellular stimulus
A0035686cellular_componentsperm fibrous sheath
A0042542biological_processresponse to hydrogen peroxide
A0042802molecular_functionidentical protein binding
A0042867biological_processpyruvate catabolic process
A0043065biological_processpositive regulation of apoptotic process
A0043627biological_processresponse to estrogen
A0051287molecular_functionNAD binding
A0051591biological_processresponse to cAMP
A1990204cellular_componentoxidoreductase complex
B0001666biological_processresponse to hypoxia
B0001889biological_processliver development
B0003824molecular_functioncatalytic activity
B0004457molecular_functionlactate dehydrogenase activity
B0004459molecular_functionL-lactate dehydrogenase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0006089biological_processlactate metabolic process
B0006090biological_processpyruvate metabolic process
B0007519biological_processskeletal muscle tissue development
B0007584biological_processresponse to nutrient
B0009410biological_processresponse to xenobiotic stimulus
B0009749biological_processresponse to glucose
B0014070biological_processresponse to organic cyclic compound
B0016491molecular_functionoxidoreductase activity
B0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B0019661biological_processglucose catabolic process to lactate via pyruvate
B0019674biological_processNAD metabolic process
B0019752biological_processcarboxylic acid metabolic process
B0019900molecular_functionkinase binding
B0031668biological_processcellular response to extracellular stimulus
B0035686cellular_componentsperm fibrous sheath
B0042542biological_processresponse to hydrogen peroxide
B0042802molecular_functionidentical protein binding
B0042867biological_processpyruvate catabolic process
B0043065biological_processpositive regulation of apoptotic process
B0043627biological_processresponse to estrogen
B0051287molecular_functionNAD binding
B0051591biological_processresponse to cAMP
B1990204cellular_componentoxidoreductase complex
C0001666biological_processresponse to hypoxia
C0001889biological_processliver development
C0003824molecular_functioncatalytic activity
C0004457molecular_functionlactate dehydrogenase activity
C0004459molecular_functionL-lactate dehydrogenase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005829cellular_componentcytosol
C0006089biological_processlactate metabolic process
C0006090biological_processpyruvate metabolic process
C0007519biological_processskeletal muscle tissue development
C0007584biological_processresponse to nutrient
C0009410biological_processresponse to xenobiotic stimulus
C0009749biological_processresponse to glucose
C0014070biological_processresponse to organic cyclic compound
C0016491molecular_functionoxidoreductase activity
C0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C0019661biological_processglucose catabolic process to lactate via pyruvate
C0019674biological_processNAD metabolic process
C0019752biological_processcarboxylic acid metabolic process
C0019900molecular_functionkinase binding
C0031668biological_processcellular response to extracellular stimulus
C0035686cellular_componentsperm fibrous sheath
C0042542biological_processresponse to hydrogen peroxide
C0042802molecular_functionidentical protein binding
C0042867biological_processpyruvate catabolic process
C0043065biological_processpositive regulation of apoptotic process
C0043627biological_processresponse to estrogen
C0051287molecular_functionNAD binding
C0051591biological_processresponse to cAMP
C1990204cellular_componentoxidoreductase complex
D0001666biological_processresponse to hypoxia
D0001889biological_processliver development
D0003824molecular_functioncatalytic activity
D0004457molecular_functionlactate dehydrogenase activity
D0004459molecular_functionL-lactate dehydrogenase activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005829cellular_componentcytosol
D0006089biological_processlactate metabolic process
D0006090biological_processpyruvate metabolic process
D0007519biological_processskeletal muscle tissue development
D0007584biological_processresponse to nutrient
D0009410biological_processresponse to xenobiotic stimulus
D0009749biological_processresponse to glucose
D0014070biological_processresponse to organic cyclic compound
D0016491molecular_functionoxidoreductase activity
D0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D0019661biological_processglucose catabolic process to lactate via pyruvate
D0019674biological_processNAD metabolic process
D0019752biological_processcarboxylic acid metabolic process
D0019900molecular_functionkinase binding
D0031668biological_processcellular response to extracellular stimulus
D0035686cellular_componentsperm fibrous sheath
D0042542biological_processresponse to hydrogen peroxide
D0042802molecular_functionidentical protein binding
D0042867biological_processpyruvate catabolic process
D0043065biological_processpositive regulation of apoptotic process
D0043627biological_processresponse to estrogen
D0051287molecular_functionNAD binding
D0051591biological_processresponse to cAMP
D1990204cellular_componentoxidoreductase complex
Functional Information from PDB Data
site_idAC1
Number of Residues12
DetailsBINDING SITE FOR RESIDUE GOL C 1332
ChainResidue
CASN163
CHOH2236
CHOH2246
DLEU69
CSER166
CALA167
CARG170
CVAL269
CHIS270
CPRO271
CMLI1338
CHOH2189

site_idAC2
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GOL C 1334
ChainResidue
BSER201
BGLY202
BASN204
BGLY207
CSER201
CGLY202
CGLY207
CSER209

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL B 1332
ChainResidue
AMET40
AHOH2048
BMET40
BASP42
BPHE70
BLEU71
BHOH2092

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL D 1332
ChainResidue
CLYS41
DMET40
DASP42
DHOH2034
DHOH2061

site_idAC5
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GOL A 1332
ChainResidue
ASER201
AGLY202
AASN204
AGLY207
ASER209
DGLY202
DASN204
DGLY207

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE GOL C 1335
ChainResidue
CSER104
CASN107
CHOH2274
CHOH2276

site_idAC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE DMS C 1333
ChainResidue
CGLY96
CALA97
C88W1336
CHOH2272
CHOH2273

site_idAC8
Number of Residues12
DetailsBINDING SITE FOR RESIDUE 88W A 1333
ChainResidue
AGLY26
AGLY28
AASP51
AVAL52
ATHR94
AALA95
AGLY96
APHE118
AILE119
AHOH2031
AHOH2035
AHOH2124

site_idAC9
Number of Residues10
DetailsBINDING SITE FOR RESIDUE 88W B 1333
ChainResidue
BASP51
BVAL52
BTHR94
BALA95
BGLY96
BARG98
BILE119
BHOH2032
BHOH2036
BHOH2106

site_idBC1
Number of Residues13
DetailsBINDING SITE FOR RESIDUE 88W C 1336
ChainResidue
CGLY28
CASP51
CVAL52
CTHR94
CALA95
CGLY96
CPHE118
CILE119
CDMS1333
CHOH2018
CHOH2022
CHOH2045
CHOH2093

site_idBC2
Number of Residues10
DetailsBINDING SITE FOR RESIDUE 88W D 1333
ChainResidue
DGLY28
DASP51
DVAL52
DTHR94
DALA95
DGLY96
DILE119
DHOH2020
DHOH2024
DHOH2076

site_idBC3
Number of Residues8
DetailsBINDING SITE FOR RESIDUE MLI C 1337
ChainResidue
CHIS192
CALA237
CTHR247
CGLN99
CARG105
CASN137
CLEU164
CARG168

site_idBC4
Number of Residues9
DetailsBINDING SITE FOR RESIDUE MLI A 1334
ChainResidue
AARG105
AASN137
ALEU164
AARG168
AHIS192
AALA237
ATHR247
AHOH2201
AHOH2302

site_idBC5
Number of Residues11
DetailsBINDING SITE FOR RESIDUE MLI B 1334
ChainResidue
BARG170
BHIS185
BTRP187
BVAL269
BHOH2195
BHOH2210
BHOH2281
BHOH2325
BHOH2326
CSER183
CHIS185

site_idBC6
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MLI B 1335
ChainResidue
BGLN99
BARG105
BASN137
BARG168
BHIS192
BALA237
BTHR247

site_idBC7
Number of Residues10
DetailsBINDING SITE FOR RESIDUE MLI A 1335
ChainResidue
AARG170
AHIS185
AVAL269
AHOH2230
AHOH2254
AHOH2327
AHOH2356
AHOH2357
DSER183
DHIS185

site_idBC8
Number of Residues12
DetailsBINDING SITE FOR RESIDUE MLI C 1338
ChainResidue
BSER183
BHIS185
BHOH2205
BHOH2206
BHOH2207
CARG170
CHIS185
CVAL269
CGOL1332
CHOH2177
CHOH2243
CHOH2246

site_idBC9
Number of Residues10
DetailsBINDING SITE FOR RESIDUE MLI D 1334
ChainResidue
DARG105
DASN137
DLEU164
DARG168
DHIS192
DALA237
DTHR247
DHOH2092
DHOH2120
DHOH2185

site_idCC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE MLI D 1335
ChainResidue
ASER183
AHIS185
AHOH2249
AHOH2250
AHOH2251
DARG170
DHIS185
DVAL269
DHOH2144
DHOH2199

Functional Information from PROSITE/UniProt
site_idPS00064
Number of Residues7
DetailsL_LDH L-lactate dehydrogenase active site. LGEHGDS
ChainResidueDetails
ALEU189-SER195

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Proton acceptor => ECO:0000250
ChainResidueDetails
AHIS192
BHIS192
CHIS192
DHIS192

site_idSWS_FT_FI2
Number of Residues24
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AGLY28
BASN137
BARG168
BTHR247
CGLY28
CARG98
CARG105
CASN137
CARG168
CTHR247
DGLY28
AARG98
DARG98
DARG105
DASN137
DARG168
DTHR247
AARG105
AASN137
AARG168
ATHR247
BGLY28
BARG98
BARG105

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: N-acetylalanine => ECO:0000269|Ref.3
ChainResidueDetails
AALA1
BALA1
CALA1
DALA1

site_idSWS_FT_FI4
Number of Residues12
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P06151
ChainResidueDetails
ALYS4
DLYS4
DLYS117
DLYS317
ALYS117
ALYS317
BLYS4
BLYS117
BLYS317
CLYS4
CLYS117
CLYS317

site_idSWS_FT_FI5
Number of Residues12
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P00338
ChainResidueDetails
ALYS13
DLYS13
DLYS80
DLYS125
ALYS80
ALYS125
BLYS13
BLYS80
BLYS125
CLYS13
CLYS80
CLYS125

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P00338
ChainResidueDetails
ALYS56
BLYS56
CLYS56
DLYS56

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903
ChainResidueDetails
ASER212
BSER212
CSER212
DSER212

site_idSWS_FT_FI8
Number of Residues12
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P06151
ChainResidueDetails
ALYS223
DLYS223
DLYS231
DLYS242
ALYS231
ALYS242
BLYS223
BLYS231
BLYS242
CLYS223
CLYS231
CLYS242

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:22673903
ChainResidueDetails
ATYR238
BTYR238
CTYR238
DTYR238

site_idSWS_FT_FI10
Number of Residues8
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:22673903
ChainResidueDetails
ATHR308
ATHR321
BTHR308
BTHR321
CTHR308
CTHR321
DTHR308
DTHR321

site_idSWS_FT_FI11
Number of Residues8
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000250|UniProtKB:P00338
ChainResidueDetails
ALYS56
BLYS56
CLYS56
DLYS56

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PDB entries from 2024-03-27

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