Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4AJ9

Catalase 3 from Neurospora crassa

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004096	molecular_function	catalase activity
A	0004601	molecular_function	peroxidase activity
A	0005829	cellular_component	cytosol
A	0006979	biological_process	response to oxidative stress
A	0020037	molecular_function	heme binding
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0046872	molecular_function	metal ion binding
A	0098869	biological_process	cellular oxidant detoxification
B	0004096	molecular_function	catalase activity
B	0004601	molecular_function	peroxidase activity
B	0005829	cellular_component	cytosol
B	0006979	biological_process	response to oxidative stress
B	0020037	molecular_function	heme binding
B	0042744	biological_process	hydrogen peroxide catabolic process
B	0046872	molecular_function	metal ion binding
B	0098869	biological_process	cellular oxidant detoxification
C	0004096	molecular_function	catalase activity
C	0004601	molecular_function	peroxidase activity
C	0005829	cellular_component	cytosol
C	0006979	biological_process	response to oxidative stress
C	0020037	molecular_function	heme binding
C	0042744	biological_process	hydrogen peroxide catabolic process
C	0046872	molecular_function	metal ion binding
C	0098869	biological_process	cellular oxidant detoxification
D	0004096	molecular_function	catalase activity
D	0004601	molecular_function	peroxidase activity
D	0005829	cellular_component	cytosol
D	0006979	biological_process	response to oxidative stress
D	0020037	molecular_function	heme binding
D	0042744	biological_process	hydrogen peroxide catabolic process
D	0046872	molecular_function	metal ion binding
D	0098869	biological_process	cellular oxidant detoxification

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT A 1716

Chain	Residue
A	VAL143
A	ASP155
A	VAL156
A	PHE181
A	VAL195

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT B 1718

Chain	Residue
B	VAL195
B	VAL143
B	ASP155
B	VAL156
B	PHE181

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT C 1721

Chain	Residue
C	VAL143
C	ALA144
C	ASP155
C	VAL156
C	PHE181
C	VAL195

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT D 1717

Chain	Residue
D	VAL143
D	ASP155
D	VAL156
D	PHE181
D	VAL195

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ACT A 1717

Chain	Residue
A	ASN176
A	ASN234
A	PRO237
A	HIS242
A	MET243
A	ALA274
A	ILE558
A	HOH2196

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT B 1719

Chain	Residue
B	ASN176
B	PRO237
B	HIS242
B	LYS273
B	ALA274
B	HOH2144

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ACT C 1722

Chain	Residue
C	ASN176
C	PRO237
C	HIS242
C	MET243
C	LYS273
C	ALA274
C	ILE558
C	HOH2128

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ACT D 1718

Chain	Residue
D	ASN176
D	ASN234
D	PRO237
D	HIS242
D	MET243
D	LYS273
D	ALA274
D	HOH2112

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE 1PE D 1719

Chain	Residue
D	ARG409

site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE 1PE C 1723

Chain	Residue
C	VAL552

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE 1PE B 1720

Chain	Residue
B	ARG409
B	VAL414

site_id	BC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE 1PE A 1718

Chain	Residue
A	LYS441

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE 1PE A 1719

Chain	Residue
A	GLU317
A	GLY460

site_id	BC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE 1PE A 1720

Chain	Residue
A	GLU709

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 1PE D 1720

Chain	Residue
D	TYR658
D	ARG659
D	ILE677
D	HOH2425

site_id	BC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE 1PE A 1721

Chain	Residue
A	VAL552

site_id	BC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE 1PE D 1721

Chain	Residue
D	LYS441

site_id	BC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE 1PE C 1724

Chain	Residue
C	GLU317
C	GLY460

site_id	CC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE 1PE B 1721

Chain	Residue
B	ASP200
D	ILE431

site_id	CC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE 1PE C 1725

Chain	Residue
D	GLN542

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE 1PE C 1726

Chain	Residue
C	TYR438
C	LYS441
D	ASN551

site_id	CC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 1PE A 1722

Chain	Residue
A	GLN652
A	THR655
A	ARG659
A	1PE1723
A	HOH2630
B	GLN652
B	THR655

site_id	CC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE 1PE B 1722

Chain	Residue
B	TYR547

site_id	CC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE 1PE B 1723

Chain	Residue
A	PRO340
B	GLY324

site_id	CC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE 1PE B 1724

Chain	Residue
B	THR600
B	GLN612

site_id	CC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 1PE A 1723

Chain	Residue
A	PHE635
A	ALA640
A	SER651
A	1PE1722
B	ARG659

site_id	CC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE 1PE D 1722

Chain	Residue
D	ALA473
D	THR474

site_id	DC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 1PE A 1724

Chain	Residue
A	GLN612
A	ALA621
A	HOH2146
A	HOH2577

site_id	DC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 1PE D 1723

Chain	Residue
D	ASN551
D	VAL552
C	LYS441
D	GLU337
D	PHE338

site_id	DC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE 1PE C 1727

Chain	Residue
C	HOH2445

site_id	DC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 1PE B 1725

Chain	Residue
A	ASP117
B	ASN487
B	SER488
B	HOH2465

site_id	DC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 1PE B 1726

Chain	Residue
A	TYR115
B	TRP118
B	LEU341
B	GLN342
B	VAL343
B	LEU344
B	HOH2285
B	HOH2553

site_id	DC6
Number of Residues	24
Details	BINDING SITE FOR RESIDUE HEM A 1715

Chain	Residue
A	ARG99
A	VAL100
A	VAL101
A	HIS102
A	ARG139
A	GLY158
A	VAL173
A	GLY174
A	ASN175
A	PHE180
A	PHE188
A	ILE248
A	HIS249
A	PHE365
A	LEU381
A	ARG385
A	SER388
A	TYR389
A	GLN393
A	ARG396
A	HOH2101
A	HOH2105
A	HOH2147
A	HOH2362

site_id	DC7
Number of Residues	25
Details	BINDING SITE FOR RESIDUE HEM B 1717

Chain	Residue
B	ARG99
B	VAL100
B	VAL101
B	HIS102
B	ARG139
B	GLY158
B	VAL173
B	GLY174
B	ASN175
B	PHE180
B	PHE188
B	ILE248
B	HIS249
B	PHE365
B	LEU381
B	ARG385
B	SER388
B	TYR389
B	THR392
B	GLN393
B	ARG396
B	HOH2071
B	HOH2073
B	HOH2108
B	HOH2300

site_id	DC8
Number of Residues	24
Details	BINDING SITE FOR RESIDUE HEM C 1720

Chain	Residue
C	ARG99
C	VAL100
C	VAL101
C	HIS102
C	ARG139
C	GLY158
C	VAL173
C	GLY174
C	ASN175
C	PHE180
C	PHE188
C	ILE248
C	HIS249
C	PHE365
C	LEU381
C	ARG385
C	SER388
C	TYR389
C	THR392
C	GLN393
C	ARG396
C	HOH2051
C	HOH2088
C	HOH2285

site_id	DC9
Number of Residues	25
Details	BINDING SITE FOR RESIDUE HEM D 1716

Chain	Residue
C	LEU88
D	ARG99
D	VAL100
D	VAL101
D	HIS102
D	ARG139
D	GLY158
D	VAL173
D	GLY174
D	ASN175
D	PHE188
D	ILE248
D	HIS249
D	PHE365
D	LEU381
D	ARG385
D	SER388
D	TYR389
D	THR392
D	GLN393
D	ARG396
D	HOH2042
D	HOH2044
D	HOH2078
D	HOH2255

Functional Information from PROSITE/UniProt

site_id	PS00438
Number of Residues	17
Details	CATALASE_2 Catalase proximal active site signature. FdHeripERvvHarGAG

Chain	Residue	Details
A	PHE91-GLY107

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: ACT_SITE => ECO:0000255\|PROSITE-ProRule:PRU10013

Chain	Residue	Details
A	HIS102
A	ASN175
B	HIS102
B	ASN175
C	HIS102
C	ASN175
D	HIS102
D	ASN175

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: axial binding residue => ECO:0000250

Chain	Residue	Details
A	TYR389
B	TYR389
C	TYR389
D	TYR389

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)