4AI7

Crystal structure of Laccase from Thermus thermophilus HB27 complexed with Hg, crystal of the apoenzyme soaked for 2 h in 5 mM HgCl2 at 278 K.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004322	molecular_function	ferroxidase activity
A	0005507	molecular_function	copper ion binding
A	0016491	molecular_function	oxidoreductase activity
A	0030288	cellular_component	outer membrane-bounded periplasmic space
A	0046872	molecular_function	metal ion binding
A	0052716	molecular_function	hydroquinone:oxygen oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE HG A 1463

Chain	Residue
A	HIS393
A	CYS445
A	HIS450
A	MET455

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE HG A 1464

Chain	Residue
A	HIS95
A	HIS97
A	HIS396
A	HIS398

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE HG A 1465

Chain	Residue
A	TRP133
A	HIS135
A	HIS446
A	HOH2134
A	HOH2203
A	HIS97

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE HG A 1466

Chain	Residue
A	HIS137
A	HIS398
A	HIS444
A	HOH2134
A	HOH2206

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MPD A 1467

Chain	Residue
A	ASP248
A	LEU263
A	GLU267
A	ARG268
A	TYR414
A	LYS418
A	MPD1478

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MPD A 1468

Chain	Residue
A	ARG280
A	TYR317
A	GLY439
A	HOH2371
A	HOH2497
A	HOH2499

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MPD A 1469

Chain	Residue
A	PRO342
A	PRO342
A	VAL343
A	VAL343
A	VAL344
A	THR345
A	THR345

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MPD A 1470

Chain	Residue
A	GLN56
A	HOH2076
A	HOH2500
A	HOH2501

---

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MPD A 1471

Chain	Residue
A	ARG75
A	PRO76
A	GLU157
A	SER158
A	SER159
A	HIS303
A	HOH2108
A	HOH2223

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MPD A 1472

Chain	Residue
A	GLY140
A	ARG453
A	MPD1481

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MPD A 1473

Chain	Residue
A	PRO144
A	PRO188
A	HIS189
A	HOH2255
A	HOH2258
A	HOH2502

---

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MPD A 1474

Chain	Residue
A	LYS31
A	VAL33

---

site_id	BC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MPD A 1475

Chain	Residue
A	PRO28
A	PHE67
A	ASN206
A	HOH2016
A	HOH2096
A	HOH2097
A	HOH2098

---

site_id	BC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE MPD A 1476

Chain	Residue
A	PRO25
A	SER26
A	GLN216
A	ASN362
A	GLN364
A	HOH2004
A	HOH2006
A	HOH2008
A	HOH2009

---

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MPD A 1477

Chain	Residue
A	ASP289
A	GLY291
A	LYS424
A	HOH2454
A	HOH2455
A	HOH2503

---

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MPD A 1478

Chain	Residue
A	LEU256
A	VAL258
A	GLU260
A	LEU261
A	MPD1467
A	HOH2339

---

site_id	BC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MPD A 1479

Chain	Residue
A	GLU127
A	LEU128
A	SER158
A	PHE251
A	SER334
A	HOH2195
A	HOH2316

---

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MPD A 1480

Chain	Residue
A	MPD1482
A	HOH2343
A	HOH2344
A	GLU257
A	ARG276

---

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MPD A 1481

Chain	Residue
A	PRO191
A	ARG453
A	MPD1472

---

site_id	CC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MPD A 1482

Chain	Residue
A	PRO241
A	ARG276
A	LYS277
A	MPD1480
A	HOH2307
A	HOH2308
A	HOH2332

---

site_id	CC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE HG A 1483

Chain	Residue
A	MET296
A	MET301
A	HIS303
A	MET305

---

Functional Information from PROSITE/UniProt

site_id	PS00080
Number of Residues	12
Details	MULTICOPPER_OXIDASE2 Multicopper oxidases signature 2. HCHiveHedrGM

Chain	Residue	Details
A	HIS444-MET455

---