4AI6
Dynein Motor Domain - ADP complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004364 | molecular_function | glutathione transferase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006749 | biological_process | glutathione metabolic process |
| A | 0007018 | biological_process | microtubule-based movement |
| A | 0008569 | molecular_function | minus-end-directed microtubule motor activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0030286 | cellular_component | dynein complex |
| A | 0045505 | molecular_function | dynein intermediate chain binding |
| A | 0051959 | molecular_function | dynein light intermediate chain binding |
| B | 0004364 | molecular_function | glutathione transferase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006749 | biological_process | glutathione metabolic process |
| B | 0007018 | biological_process | microtubule-based movement |
| B | 0008569 | molecular_function | minus-end-directed microtubule motor activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016887 | molecular_function | ATP hydrolysis activity |
| B | 0030286 | cellular_component | dynein complex |
| B | 0045505 | molecular_function | dynein intermediate chain binding |
| B | 0051959 | molecular_function | dynein light intermediate chain binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE ATP A 5400 |
| Chain | Residue |
| A | SER2048 |
| A | CYS2220 |
| A | SER2224 |
| A | LYS2225 |
| A | HIS2228 |
| A | ARG2507 |
| A | GLU2511 |
| A | ARG2549 |
| A | ARG2552 |
| B | MG5404 |
| A | GLY2077 |
| A | CYS2078 |
| A | GLY2079 |
| A | LYS2080 |
| A | THR2081 |
| A | ALA2082 |
| A | GLU2195 |
| A | VAL2219 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE ADP A 5401 |
| Chain | Residue |
| A | ILE2392 |
| A | PRO2419 |
| A | PRO2420 |
| A | GLY2421 |
| A | SER2422 |
| A | GLY2423 |
| A | LYS2424 |
| A | THR2425 |
| A | MET2426 |
| A | ILE2570 |
| A | TYR2571 |
| A | PRO2619 |
| A | ARG2620 |
| A | THR2623 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE ADP A 5402 |
| Chain | Residue |
| A | MET2732 |
| A | VAL2733 |
| A | HIS2735 |
| A | ARG2763 |
| A | THR2764 |
| A | GLY2765 |
| A | LYS2766 |
| A | THR2767 |
| A | ILE2768 |
| A | ARG3512 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 5403 |
| Chain | Residue |
| A | GLY1799 |
| A | THR1800 |
| A | GLY1801 |
| A | LYS1802 |
| A | THR1803 |
| A | GLU1849 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 5404 |
| Chain | Residue |
| B | LYS2080 |
| B | THR2081 |
| B | ASP2155 |
| B | GLU2195 |
| B | ATP5400 |
| site_id | AC6 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE ATP B 5400 |
| Chain | Residue |
| A | MG5404 |
| B | SER2048 |
| B | GLY2077 |
| B | CYS2078 |
| B | GLY2079 |
| B | LYS2080 |
| B | THR2081 |
| B | ALA2082 |
| B | ASP2155 |
| B | GLU2195 |
| B | VAL2219 |
| B | CYS2220 |
| B | SER2224 |
| B | LYS2225 |
| B | HIS2228 |
| B | ARG2507 |
| B | GLU2511 |
| B | ARG2549 |
| B | ARG2552 |
| site_id | AC7 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE ADP B 5401 |
| Chain | Residue |
| B | ILE2390 |
| B | ILE2392 |
| B | PRO2419 |
| B | PRO2420 |
| B | GLY2421 |
| B | GLY2423 |
| B | LYS2424 |
| B | THR2425 |
| B | MET2426 |
| B | ILE2570 |
| B | TYR2571 |
| B | ARG2620 |
| B | THR2623 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE ADP B 5402 |
| Chain | Residue |
| B | MET2732 |
| B | VAL2733 |
| B | ARG2763 |
| B | THR2764 |
| B | GLY2765 |
| B | LYS2766 |
| B | THR2767 |
| B | ILE2768 |
| B | ARG3512 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 5403 |
| Chain | Residue |
| B | THR1803 |
| B | ALA1798 |
| B | GLY1799 |
| B | THR1800 |
| B | GLY1801 |
| B | LYS1802 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 5404 |
| Chain | Residue |
| A | THR2081 |
| A | ASP2155 |
| A | GLU2195 |
| A | GLU2511 |
| A | ATP5400 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:7538846, ECO:0000305|PubMed:12596270 |
| Chain | Residue | Details |
| A | TYR6 | |
| A | TRP40 | |
| A | ASN53 | |
| A | GLN66 | |
| B | TYR6 | |
| B | TRP40 | |
| B | ASN53 | |
| B | GLN66 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305 |
| Chain | Residue | Details |
| A | TYR110 | |
| B | TYR110 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY1796 | |
| A | GLY2074 | |
| A | GLY2418 | |
| A | GLY2760 | |
| B | GLY1796 | |
| B | GLY2074 | |
| B | GLY2418 | |
| B | GLY2760 |
