4AG2

Human Chymase - Fynomer Complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002003	biological_process	angiotensin maturation
A	0004175	molecular_function	endopeptidase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006508	biological_process	proteolysis
A	0006518	biological_process	peptide metabolic process
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0016485	biological_process	protein processing
A	0016787	molecular_function	hydrolase activity
A	0022617	biological_process	extracellular matrix disassembly
A	0030141	cellular_component	secretory granule
A	0030163	biological_process	protein catabolic process
A	0030901	biological_process	midbrain development
A	0031012	cellular_component	extracellular matrix
A	0034769	biological_process	basement membrane disassembly
A	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
A	0042277	molecular_function	peptide binding
A	0045766	biological_process	positive regulation of angiogenesis
A	0050727	biological_process	regulation of inflammatory response
A	0051604	biological_process	protein maturation
A	0071333	biological_process	cellular response to glucose stimulus
A	0140447	biological_process	cytokine precursor processing
B	0002003	biological_process	angiotensin maturation
B	0004175	molecular_function	endopeptidase activity
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0006508	biological_process	proteolysis
B	0006518	biological_process	peptide metabolic process
B	0008233	molecular_function	peptidase activity
B	0008236	molecular_function	serine-type peptidase activity
B	0016485	biological_process	protein processing
B	0016787	molecular_function	hydrolase activity
B	0022617	biological_process	extracellular matrix disassembly
B	0030141	cellular_component	secretory granule
B	0030163	biological_process	protein catabolic process
B	0030901	biological_process	midbrain development
B	0031012	cellular_component	extracellular matrix
B	0034769	biological_process	basement membrane disassembly
B	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
B	0042277	molecular_function	peptide binding
B	0045766	biological_process	positive regulation of angiogenesis
B	0050727	biological_process	regulation of inflammatory response
B	0051604	biological_process	protein maturation
B	0071333	biological_process	cellular response to glucose stimulus
B	0140447	biological_process	cytokine precursor processing

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE MES C 1060

Chain	Residue
B	HIS156
C	HOH2058
C	HOH2062
B	ARG200
B	LYS204
B	PRO205
B	HOH2130
C	TYR9
C	ASN54
C	TYR55
C	HOH2009

---

site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE MES A 1227

Chain	Residue
A	ARG200
A	LYS204
A	PRO205
A	HOH2171
A	HOH2210
A	HOH2228
D	TYR9
D	ASN54
D	TYR55
D	HOH2006
D	HOH2037

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE LMR B 1227

Chain	Residue
B	PHE29
B	HIS45
B	LYS179
B	GLY180
B	SER182
B	HOH2175
D	TRP16

---

site_id	AC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE LMR B 1228

Chain	Residue
A	ARG158
B	HIS156
B	PHE157
B	ARG200
B	HOH2132
B	HOH2177
B	HOH2178
B	HOH2179
C	HOH2057
D	THR14
D	ARG15

---

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE LMR A 1228

Chain	Residue
A	HIS156
A	PHE157
A	ARG200
A	HOH2173
A	HOH2207
A	HOH2229
A	HOH2230
B	ARG158
C	THR14
C	ARG15

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 1229

Chain	Residue
A	GLU97
A	LYS98
A	GLY137
A	ASP139
A	HOH2058

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 1230

Chain	Residue
A	HOH2114
A	HOH2231
A	HOH2232
B	ARG158
B	PHE160

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA C 1061

Chain	Residue
A	HOH2196
A	HOH2197
A	HOH2198
C	THR48
C	HOH2052
C	HOH2053

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA D 1061

Chain	Residue
B	PHE114
D	GLY32
D	GLY35
D	TRP38
D	HOH2027
D	HOH2028

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 1231

Chain	Residue
A	ARG158
A	PHE160
A	HOH2172
A	HOH2176
A	HOH2180
B	SER84

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
A	LEU41-CYS46

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. SAfkGDSGGPLL

Chain	Residue	Details
A	SER176-LEU187

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Active site: {"description":"Charge relay system"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2071582","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	223
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---