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4AFU

Human Chymase - Fynomer Complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0002003biological_processangiotensin maturation
A0004175molecular_functionendopeptidase activity
A0004252molecular_functionserine-type endopeptidase activity
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006508biological_processproteolysis
A0006518biological_processpeptide metabolic process
A0008236molecular_functionserine-type peptidase activity
A0016485biological_processprotein processing
A0022617biological_processextracellular matrix disassembly
A0030141cellular_componentsecretory granule
A0030163biological_processprotein catabolic process
A0030901biological_processmidbrain development
A0034769biological_processbasement membrane disassembly
A0036464cellular_componentcytoplasmic ribonucleoprotein granule
A0042277molecular_functionpeptide binding
A0043231cellular_componentintracellular membrane-bounded organelle
A0045766biological_processpositive regulation of angiogenesis
A0050727biological_processregulation of inflammatory response
A0062023cellular_componentcollagen-containing extracellular matrix
A0071333biological_processcellular response to glucose stimulus
A0140447biological_processcytokine precursor processing
B0002003biological_processangiotensin maturation
B0004175molecular_functionendopeptidase activity
B0004252molecular_functionserine-type endopeptidase activity
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006508biological_processproteolysis
B0006518biological_processpeptide metabolic process
B0008236molecular_functionserine-type peptidase activity
B0016485biological_processprotein processing
B0022617biological_processextracellular matrix disassembly
B0030141cellular_componentsecretory granule
B0030163biological_processprotein catabolic process
B0030901biological_processmidbrain development
B0034769biological_processbasement membrane disassembly
B0036464cellular_componentcytoplasmic ribonucleoprotein granule
B0042277molecular_functionpeptide binding
B0043231cellular_componentintracellular membrane-bounded organelle
B0045766biological_processpositive regulation of angiogenesis
B0050727biological_processregulation of inflammatory response
B0062023cellular_componentcollagen-containing extracellular matrix
B0071333biological_processcellular response to glucose stimulus
B0140447biological_processcytokine precursor processing
Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC
ChainResidueDetails
ALEU41-CYS46

site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. SAfkGDSGGPLL
ChainResidueDetails
ASER176-LEU187

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsACT_SITE: Charge relay system
ChainResidueDetails
AHIS45
AASP89
ASER182
BHIS45
BASP89
BSER182

site_idSWS_FT_FI2
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:2071582
ChainResidueDetails
AASN59
BASN59

site_idSWS_FT_FI3
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
ChainResidueDetails
AASN82
BASN82

221051

PDB entries from 2024-06-12

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