4AFS
Human Chymase - Fynomer Complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002003 | biological_process | angiotensin maturation |
| A | 0004175 | molecular_function | endopeptidase activity |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005829 | cellular_component | cytosol |
| A | 0006508 | biological_process | proteolysis |
| A | 0006518 | biological_process | peptide metabolic process |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0016485 | biological_process | protein processing |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0022617 | biological_process | extracellular matrix disassembly |
| A | 0030141 | cellular_component | secretory granule |
| A | 0030163 | biological_process | protein catabolic process |
| A | 0030901 | biological_process | midbrain development |
| A | 0034769 | biological_process | basement membrane disassembly |
| A | 0036464 | cellular_component | cytoplasmic ribonucleoprotein granule |
| A | 0042277 | molecular_function | peptide binding |
| A | 0045766 | biological_process | positive regulation of angiogenesis |
| A | 0050727 | biological_process | regulation of inflammatory response |
| A | 0051604 | biological_process | protein maturation |
| A | 0062023 | cellular_component | collagen-containing extracellular matrix |
| A | 0071333 | biological_process | cellular response to glucose stimulus |
| A | 0140447 | biological_process | cytokine precursor processing |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1227 |
| Chain | Residue |
| A | HIS10 |
| A | GLU64 |
| A | HOH2019 |
| C | HIS22 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PO4 A 1228 |
| Chain | Residue |
| A | HOH2092 |
| A | HOH2152 |
| A | HOH2152 |
| A | HOH2153 |
| A | ARG124 |
| A | ARG124 |
| A | ALA189 |
| A | GLY190 |
| A | HOH2092 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 A 1229 |
| Chain | Residue |
| A | PHE29 |
| A | HIS45 |
| A | LYS179 |
| A | GLY180 |
| A | SER182 |
| A | HOH2131 |
| A | HOH2154 |
| C | TRP16 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 1230 |
| Chain | Residue |
| A | ASN115 |
| A | ASN115 |
| A | ARG121 |
| A | ARG121 |
| A | GLN193 |
| A | HOH2133 |
| A | HOH2133 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PO4 A 1231 |
| Chain | Residue |
| A | ARG124 |
| A | LYS145 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | ACT_SITE: Charge relay system |
| Chain | Residue | Details |
| A | HIS45 | |
| A | ASP89 | |
| A | SER182 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:2071582 |
| Chain | Residue | Details |
| A | ASN59 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 |
| Chain | Residue | Details |
| A | ASN82 |
