4AFR
THE STRUCTURE OF METACASPASE 2 (C213A MUTANT) FROM T. BRUCEI
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005768 | cellular_component | endosome |
| A | 0006508 | biological_process | proteolysis |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0055037 | cellular_component | recycling endosome |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:Q08601 |
| Chain | Residue | Details |
| A | HIS158 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000305|PubMed:18005666 |
| Chain | Residue | Details |
| A | ALA213 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22529389, ECO:0007744|PDB:4AFP |
| Chain | Residue | Details |
| A | ASP173 | |
| A | ASP189 | |
| A | ASP190 | |
| A | ASP220 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by autolysis => ECO:0000269|PubMed:18005666 |
| Chain | Residue | Details |
| A | LYS55 | |
| A | LYS268 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | SITE: Important for Arg/Lys-specific substrate specificity => ECO:0000269|PubMed:22529389 |
| Chain | Residue | Details |
| A | ASP95 | |
| A | ASP211 |
