4AFR

THE STRUCTURE OF METACASPASE 2 (C213A MUTANT) FROM T. BRUCEI

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity
A	0055037	cellular_component	recycling endosome

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"evidences":[{"source":"UniProtKB","id":"Q08601","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"evidences":[{"source":"PubMed","id":"18005666","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22529389","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4AFP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Cleavage; by autolysis","evidences":[{"source":"PubMed","id":"18005666","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Site: {"description":"Important for Arg/Lys-specific substrate specificity","evidences":[{"source":"PubMed","id":"22529389","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---