4AFN

Crystal structure of 3-ketoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa at 2.3A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
A	0006633	biological_process	fatty acid biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0030497	biological_process	fatty acid elongation
A	0050661	molecular_function	NADP binding
A	0051287	molecular_function	NAD binding
B	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
B	0006633	biological_process	fatty acid biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0030497	biological_process	fatty acid elongation
B	0050661	molecular_function	NADP binding
B	0051287	molecular_function	NAD binding
C	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
C	0006633	biological_process	fatty acid biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0030497	biological_process	fatty acid elongation
C	0050661	molecular_function	NADP binding
C	0051287	molecular_function	NAD binding
D	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
D	0006633	biological_process	fatty acid biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0030497	biological_process	fatty acid elongation
D	0050661	molecular_function	NADP binding
D	0051287	molecular_function	NAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 1PE A 1248

Chain	Residue
A	SER2
A	GLN4
A	LYS6
A	TRP133
A	ASP228

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 1PE C 1248

Chain	Residue
C	LYS6
C	TRP133
C	ASP228
C	HOH2006

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site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE 1PE D 1248

Chain	Residue
D	LYS6
D	TRP133

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Functional Information from PROSITE/UniProt

site_id	PS00061
Number of Residues	29
Details	ADH_SHORT Short-chain dehydrogenases/reductases family signature. SvvgamgnagQtnYAAAKAGLeGFTrALA

Chain	Residue	Details
A	SER141-ALA169

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10001

Chain	Residue	Details
A	TYR154
B	TYR154
C	TYR154
D	TYR154

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site_id	SWS_FT_FI2
Number of Residues	28
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	GLY12
B	ASP62
B	ASN89
B	SER141
B	TYR154
B	ILE187
C	GLY12
C	THR37
C	ASP62
C	ASN89
C	SER141
A	THR37
C	TYR154
C	ILE187
D	GLY12
D	THR37
D	ASP62
D	ASN89
D	SER141
D	TYR154
D	ILE187
A	ASP62
A	ASN89
A	SER141
A	TYR154
A	ILE187
B	GLY12
B	THR37

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