4AE0

Crystal structure of diphtheria toxin mutant CRM197

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005886	cellular_component	plasma membrane
A	0008320	molecular_function	protein transmembrane transporter activity
A	0016757	molecular_function	glycosyltransferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0035821	biological_process	modulation of process of another organism
A	0042802	molecular_function	identical protein binding
A	0047286	molecular_function	NAD+-diphthamide ADP-ribosyltransferase activity
A	0071806	biological_process	protein transmembrane transport
A	0090729	molecular_function	toxin activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE:

Chain	Residue	Details
A	GLU148

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING:

Chain	Residue	Details
A	HIS21
A	TYR65

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Modification inactivates enzyme

Chain	Residue	Details
A	TRP153

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site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Cleavage; by furin => ECO:0000269|PubMed:8253774

Chain	Residue	Details
A	ARG193

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	1
Details	M-CSA 773

Chain	Residue	Details
A	GLU148	electrostatic stabiliser

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