Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4ADX

The Cryo-EM Structure of the Archaeal 50S Ribosomal Subunit in Complex with Initiation Factor 6

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0003723	molecular_function	RNA binding
1	0003735	molecular_function	structural constituent of ribosome
1	0005840	cellular_component	ribosome
1	0006412	biological_process	translation
1	0008270	molecular_function	zinc ion binding
1	0019843	molecular_function	rRNA binding
1	0022625	cellular_component	cytosolic large ribosomal subunit
1	0046872	molecular_function	metal ion binding
1	1990904	cellular_component	ribonucleoprotein complex
2	0003735	molecular_function	structural constituent of ribosome
2	0005840	cellular_component	ribosome
2	0006412	biological_process	translation
2	0019843	molecular_function	rRNA binding
2	0022625	cellular_component	cytosolic large ribosomal subunit
2	1990904	cellular_component	ribonucleoprotein complex
3	0000049	molecular_function	tRNA binding
3	0003735	molecular_function	structural constituent of ribosome
3	0005840	cellular_component	ribosome
3	0006412	biological_process	translation
3	0008270	molecular_function	zinc ion binding
3	0019843	molecular_function	rRNA binding
3	0046872	molecular_function	metal ion binding
3	0070180	molecular_function	large ribosomal subunit rRNA binding
3	1990904	cellular_component	ribonucleoprotein complex
4	0003735	molecular_function	structural constituent of ribosome
4	0005829	cellular_component	cytosol
4	0005840	cellular_component	ribosome
4	0006412	biological_process	translation
4	1990904	cellular_component	ribonucleoprotein complex
5	0003735	molecular_function	structural constituent of ribosome
5	0005634	cellular_component	nucleus
5	0005737	cellular_component	cytoplasm
5	0005840	cellular_component	ribosome
5	0006412	biological_process	translation
5	0016567	biological_process	protein ubiquitination
5	0019941	biological_process	modification-dependent protein catabolic process
5	0031386	molecular_function	protein tag activity
5	0031625	molecular_function	ubiquitin protein ligase binding
5	1990904	cellular_component	ribonucleoprotein complex
6	0003723	molecular_function	RNA binding
6	0003735	molecular_function	structural constituent of ribosome
6	0005840	cellular_component	ribosome
6	0022625	cellular_component	cytosolic large ribosomal subunit
6	1990904	cellular_component	ribonucleoprotein complex
7	0003723	molecular_function	RNA binding
7	0003735	molecular_function	structural constituent of ribosome
7	0005840	cellular_component	ribosome
7	0006412	biological_process	translation
7	0022625	cellular_component	cytosolic large ribosomal subunit
7	0042273	biological_process	ribosomal large subunit biogenesis
7	1990904	cellular_component	ribonucleoprotein complex
A	0002181	biological_process	cytoplasmic translation
A	0003723	molecular_function	RNA binding
A	0003735	molecular_function	structural constituent of ribosome
A	0005840	cellular_component	ribosome
A	0006412	biological_process	translation
A	0015934	cellular_component	large ribosomal subunit
A	0019843	molecular_function	rRNA binding
A	0022625	cellular_component	cytosolic large ribosomal subunit
A	0022626	cellular_component	cytosolic ribosome
A	1990904	cellular_component	ribonucleoprotein complex
B	0003723	molecular_function	RNA binding
B	0003735	molecular_function	structural constituent of ribosome
B	0005840	cellular_component	ribosome
B	0006412	biological_process	translation
B	0019843	molecular_function	rRNA binding
B	0022625	cellular_component	cytosolic large ribosomal subunit
B	1990904	cellular_component	ribonucleoprotein complex
C	0003723	molecular_function	RNA binding
C	0003735	molecular_function	structural constituent of ribosome
C	0005840	cellular_component	ribosome
C	0006412	biological_process	translation
C	0019843	molecular_function	rRNA binding
C	0022625	cellular_component	cytosolic large ribosomal subunit
C	1990904	cellular_component	ribonucleoprotein complex
D	0000049	molecular_function	tRNA binding
D	0003723	molecular_function	RNA binding
D	0003735	molecular_function	structural constituent of ribosome
D	0005840	cellular_component	ribosome
D	0006412	biological_process	translation
D	0019843	molecular_function	rRNA binding
D	0022625	cellular_component	cytosolic large ribosomal subunit
D	1990904	cellular_component	ribonucleoprotein complex
E	0002181	biological_process	cytoplasmic translation
E	0003735	molecular_function	structural constituent of ribosome
E	0005840	cellular_component	ribosome
E	0006412	biological_process	translation
E	0019843	molecular_function	rRNA binding
E	0022625	cellular_component	cytosolic large ribosomal subunit
E	1990904	cellular_component	ribonucleoprotein complex
F	0001682	biological_process	tRNA 5'-leader removal
F	0003723	molecular_function	RNA binding
F	0003735	molecular_function	structural constituent of ribosome
F	0004526	molecular_function	ribonuclease P activity
F	0005737	cellular_component	cytoplasm
F	0005840	cellular_component	ribosome
F	0006412	biological_process	translation
F	0008033	biological_process	tRNA processing
F	0019843	molecular_function	rRNA binding
F	0042254	biological_process	ribosome biogenesis
F	1990904	cellular_component	ribonucleoprotein complex
G	0003735	molecular_function	structural constituent of ribosome
G	0005840	cellular_component	ribosome
G	0006412	biological_process	translation
G	0019843	molecular_function	rRNA binding
G	0070180	molecular_function	large ribosomal subunit rRNA binding
G	1990904	cellular_component	ribonucleoprotein complex
H	0000027	biological_process	ribosomal large subunit assembly
H	0000049	molecular_function	tRNA binding
H	0003735	molecular_function	structural constituent of ribosome
H	0005840	cellular_component	ribosome
H	0006412	biological_process	translation
H	0019843	molecular_function	rRNA binding
H	0022625	cellular_component	cytosolic large ribosomal subunit
H	1990904	cellular_component	ribonucleoprotein complex
I	0000460	biological_process	maturation of 5.8S rRNA
I	0000470	biological_process	maturation of LSU-rRNA
I	0003743	molecular_function	translation initiation factor activity
I	0005829	cellular_component	cytosol
I	0006412	biological_process	translation
I	0006413	biological_process	translational initiation
I	0030687	cellular_component	preribosome, large subunit precursor
I	0042256	biological_process	cytosolic ribosome assembly
I	0043022	molecular_function	ribosome binding
I	0043023	molecular_function	ribosomal large subunit binding
I	1902626	biological_process	assembly of large subunit precursor of preribosome
J	0003735	molecular_function	structural constituent of ribosome
J	0005840	cellular_component	ribosome
J	0006412	biological_process	translation
J	0015934	cellular_component	large ribosomal subunit
K	0003735	molecular_function	structural constituent of ribosome
K	0005840	cellular_component	ribosome
K	0006412	biological_process	translation
K	0019843	molecular_function	rRNA binding
K	0022625	cellular_component	cytosolic large ribosomal subunit
K	0070180	molecular_function	large ribosomal subunit rRNA binding
K	1990904	cellular_component	ribonucleoprotein complex
L	0003735	molecular_function	structural constituent of ribosome
L	0005737	cellular_component	cytoplasm
L	0005840	cellular_component	ribosome
L	0006412	biological_process	translation
L	0015934	cellular_component	large ribosomal subunit
L	0019843	molecular_function	rRNA binding
L	0022625	cellular_component	cytosolic large ribosomal subunit
L	0043232	cellular_component	intracellular non-membrane-bounded organelle
L	1990904	cellular_component	ribonucleoprotein complex
M	0002181	biological_process	cytoplasmic translation
M	0003723	molecular_function	RNA binding
M	0003735	molecular_function	structural constituent of ribosome
M	0005840	cellular_component	ribosome
M	0006412	biological_process	translation
M	0019843	molecular_function	rRNA binding
M	0022625	cellular_component	cytosolic large ribosomal subunit
M	0022626	cellular_component	cytosolic ribosome
M	1990904	cellular_component	ribonucleoprotein complex
N	0000027	biological_process	ribosomal large subunit assembly
N	0003735	molecular_function	structural constituent of ribosome
N	0005840	cellular_component	ribosome
N	0006412	biological_process	translation
N	0008097	molecular_function	5S rRNA binding
N	0019843	molecular_function	rRNA binding
N	0022625	cellular_component	cytosolic large ribosomal subunit
N	1990904	cellular_component	ribonucleoprotein complex
O	0003723	molecular_function	RNA binding
O	0003735	molecular_function	structural constituent of ribosome
O	0005737	cellular_component	cytoplasm
O	0005840	cellular_component	ribosome
O	0006412	biological_process	translation
O	0019843	molecular_function	rRNA binding
O	0022625	cellular_component	cytosolic large ribosomal subunit
O	0043232	cellular_component	intracellular non-membrane-bounded organelle
O	1990904	cellular_component	ribonucleoprotein complex
P	0003723	molecular_function	RNA binding
P	0003735	molecular_function	structural constituent of ribosome
P	0005840	cellular_component	ribosome
P	0006412	biological_process	translation
P	0019843	molecular_function	rRNA binding
P	0022625	cellular_component	cytosolic large ribosomal subunit
P	0070180	molecular_function	large ribosomal subunit rRNA binding
P	1990904	cellular_component	ribonucleoprotein complex
Q	0003735	molecular_function	structural constituent of ribosome
Q	0005840	cellular_component	ribosome
Q	0006412	biological_process	translation
Q	0019843	molecular_function	rRNA binding
Q	1990904	cellular_component	ribonucleoprotein complex
R	0002181	biological_process	cytoplasmic translation
R	0003735	molecular_function	structural constituent of ribosome
R	0005840	cellular_component	ribosome
R	0006412	biological_process	translation
R	0015934	cellular_component	large ribosomal subunit
R	0019843	molecular_function	rRNA binding
R	0022625	cellular_component	cytosolic large ribosomal subunit
R	1990904	cellular_component	ribonucleoprotein complex
S	0000027	biological_process	ribosomal large subunit assembly
S	0003735	molecular_function	structural constituent of ribosome
S	0005840	cellular_component	ribosome
S	0006412	biological_process	translation
S	0019843	molecular_function	rRNA binding
S	0022625	cellular_component	cytosolic large ribosomal subunit
S	1990904	cellular_component	ribonucleoprotein complex
T	0002181	biological_process	cytoplasmic translation
T	0003723	molecular_function	RNA binding
T	0003735	molecular_function	structural constituent of ribosome
T	0005840	cellular_component	ribosome
T	0006412	biological_process	translation
T	0015934	cellular_component	large ribosomal subunit
T	0019843	molecular_function	rRNA binding
T	0022625	cellular_component	cytosolic large ribosomal subunit
T	0042273	biological_process	ribosomal large subunit biogenesis
T	1990904	cellular_component	ribonucleoprotein complex
U	0003735	molecular_function	structural constituent of ribosome
U	0005840	cellular_component	ribosome
U	0006412	biological_process	translation
U	0008270	molecular_function	zinc ion binding
U	0019843	molecular_function	rRNA binding
U	0046872	molecular_function	metal ion binding
U	1990904	cellular_component	ribonucleoprotein complex
V	0003735	molecular_function	structural constituent of ribosome
V	0005840	cellular_component	ribosome
V	0006412	biological_process	translation
V	0019843	molecular_function	rRNA binding
V	0022625	cellular_component	cytosolic large ribosomal subunit
V	1990904	cellular_component	ribonucleoprotein complex
W	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
W	0003723	molecular_function	RNA binding
W	0003735	molecular_function	structural constituent of ribosome
W	0005840	cellular_component	ribosome
W	0006412	biological_process	translation
W	0015934	cellular_component	large ribosomal subunit
W	0019843	molecular_function	rRNA binding
W	0022625	cellular_component	cytosolic large ribosomal subunit
W	1990904	cellular_component	ribonucleoprotein complex
X	0002181	biological_process	cytoplasmic translation
X	0003735	molecular_function	structural constituent of ribosome
X	0005840	cellular_component	ribosome
X	0006412	biological_process	translation
X	0019843	molecular_function	rRNA binding
X	0022625	cellular_component	cytosolic large ribosomal subunit
X	1990904	cellular_component	ribonucleoprotein complex
Y	0000166	molecular_function	nucleotide binding
Y	0003677	molecular_function	DNA binding
Y	0003735	molecular_function	structural constituent of ribosome
Y	0005840	cellular_component	ribosome
Y	0006281	biological_process	DNA repair
Y	0006412	biological_process	translation
Y	0019843	molecular_function	rRNA binding
Y	0022625	cellular_component	cytosolic large ribosomal subunit
Y	1990904	cellular_component	ribonucleoprotein complex
Z	0003735	molecular_function	structural constituent of ribosome
Z	0005840	cellular_component	ribosome
Z	0006412	biological_process	translation
Z	0008270	molecular_function	zinc ion binding
Z	0019843	molecular_function	rRNA binding
Z	0046872	molecular_function	metal ion binding
Z	0070180	molecular_function	large ribosomal subunit rRNA binding
Z	1990904	cellular_component	ribonucleoprotein complex

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DGNTDGEVDlpDV

Chain	Residue	Details
C	ASP9-VAL21

site_id	PS00049
Number of Residues	27
Details	RIBOSOMAL_L14 Ribosomal protein L14 signature. AVVVrqrkpirrp.DGtrvkFedNaaVI

Chain	Residue	Details
K	ALA71-ILE97

site_id	PS00050
Number of Residues	16
Details	RIBOSOMAL_L23 Ribosomal protein L23 signature. KKAVVRLSedddaqeV

Chain	Residue	Details
S	LYS62-VAL77

site_id	PS00051
Number of Residues	17
Details	RIBOSOMAL_L39E Ribosomal protein L39e signature. KTdreVqrNhkrRHWRR

Chain	Residue	Details
2	LYS28-ARG44

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
5	LYS27-ASP52

site_id	PS00358
Number of Residues	17
Details	RIBOSOMAL_L5 Ribosomal protein L5 signature. LgeITGQmpVrTkAKrT

Chain	Residue	Details
D	LEU41-THR57

site_id	PS00464
Number of Residues	25
Details	RIBOSOMAL_L22 Ribosomal protein L22 signature. QgrKpRAmGRasawnspqVDVELiL

Chain	Residue	Details
R	GLN123-LEU147

site_id	PS00467
Number of Residues	12
Details	RIBOSOMAL_L2 Ribosomal protein L2 signature. PnvRGVAmNAvD

Chain	Residue	Details
A	PRO187-ASP198

site_id	PS00474
Number of Residues	24
Details	RIBOSOMAL_L3 Ribosomal protein L3 signature. FrageyaDvaGvTkGKGtqGpvkR

Chain	Residue	Details
B	PHE194-ARG217

site_id	PS00475
Number of Residues	31
Details	RIBOSOMAL_L15 Ribosomal protein L15 signature. KVLGsGvLqkd..VtVaavdFSgtAetkIdqvG

Chain	Residue	Details
O	LYS63-GLY93
L	LYS107-GLY137

site_id	PS00526
Number of Residues	20
Details	RIBOSOMAL_L19E Ribosomal protein L19e signature. QKRLaAdvldVGknrVWFNP

Chain	Residue	Details
P	GLN6-PRO25

site_id	PS00579
Number of Residues	15
Details	RIBOSOMAL_L29 Ribosomal protein L29 signature. NPGRIKeLRKAIARI

Chain	Residue	Details
V	ASN42-ILE56

site_id	PS00580
Number of Residues	21
Details	RIBOSOMAL_L32E Ribosomal protein L32e signature. FnRqdhhKkkRVsts..WRKprG

Chain	Residue	Details
Y	PHE128-GLY148

site_id	PS00634
Number of Residues	33
Details	RIBOSOMAL_L30 Ribosomal protein L30 signature. TLemLnIhHvnHcTlvpetdayrgMVakVndFV

Chain	Residue	Details
W	THR20-VAL52

site_id	PS00700
Number of Residues	22
Details	RIBOSOMAL_L6_2 Ribosomal protein L6 signature 2. QltrIndKdvRvFqDGVYItrK

Chain	Residue	Details
E	GLN150-LYS171

site_id	PS00783
Number of Residues	24
Details	RIBOSOMAL_L13 Ribosomal protein L13 signature. IRGMLPhkkqrGReafesVrVYlG

Chain	Residue	Details
J	ILE83-GLY106

site_id	PS00939
Number of Residues	27
Details	RIBOSOMAL_L1E Ribosomal protein L1e signature. NdkeRqlAVrSALaATAdadlvadRGH

Chain	Residue	Details
C	ASN103-HIS129

site_id	PS00993
Number of Residues	21
Details	RIBOSOMAL_L30E_2 Ribosomal protein L30e signature 2. ELGTacGKyhrcstMaIlDaG

Chain	Residue	Details
6	GLU76-GLY96

site_id	PS01073
Number of Residues	18
Details	RIBOSOMAL_L24E Ribosomal protein L24e signature. YcGtdIePGtGtmFvHkD

Chain	Residue	Details
U	TYR8-ASP25

site_id	PS01077
Number of Residues	20
Details	RIBOSOMAL_L37E Ribosomal protein L37e signature. GTpSqGkKnttt.HtkCrRCG

Chain	Residue	Details
1	GLY4-GLY23

site_id	PS01082
Number of Residues	18
Details	RIBOSOMAL_L7AE Ribosomal protein L7Ae signature. AdekgVPFifVeQQddLG

Chain	Residue	Details
F	ALA67-GLY84

site_id	PS01106
Number of Residues	18
Details	RIBOSOMAL_L18E Ribosomal protein L18e signature. ErLekPRrtHAeVNLgRI

Chain	Residue	Details
O	GLU31-ILE48

site_id	PS01108
Number of Residues	18
Details	RIBOSOMAL_L24 Ribosomal protein L24 signature. GDtVeVLrGdfAGee.GeV

Chain	Residue	Details
T	GLY45-VAL62

site_id	PS01144
Number of Residues	15
Details	RIBOSOMAL_L31E Ribosomal protein L31e signature. VRLDpsINeAaWaRG

Chain	Residue	Details
X	VAL48-GLY62

site_id	PS01145
Number of Residues	14
Details	RIBOSOMAL_L34E Ribosomal protein L34e signature. TrSnKvrkvKTPGG

Chain	Residue	Details
4	THR15-GLY28

site_id	PS01171
Number of Residues	26
Details	RIBOSOMAL_L21E Ribosomal protein L21e signature. GEkVhlkidpsvpn.GrfHprFdGqTG

Chain	Residue	Details
Q	GLY36-GLY61

site_id	PS01172
Number of Residues	12
Details	RIBOSOMAL_L44E Ribosomal protein L44e signature. KpTKKtdLKyrC

Chain	Residue	Details
3	LYS60-CYS71

site_id	PS01194
Number of Residues	24
Details	RIBOSOMAL_L15E Ribosomal protein L15e signature. DKARsQGYkAkqGVIVARvSVrKG

Chain	Residue	Details
M	ASP47-GLY70

site_id	PS01257
Number of Residues	22
Details	RIBOSOMAL_L10E Ribosomal protein L10e signature. ADRvsdGMRaAFGKIvGtaARV

Chain	Residue	Details
H	ALA109-VAL130

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	21
Details	ZN_FING: C4-type => ECO:0000255\|HAMAP-Rule:MF_00327

Chain	Residue	Details
Z	CYS63-CYS84

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00327

Chain	Residue	Details
Z	CYS63
Z	CYS66
Z	CYS81
Z	CYS84

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)