4ADM

Crystal structure of Rv1098c in complex with meso-tartrate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004333	molecular_function	fumarate hydratase activity
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006099	biological_process	tricarboxylic acid cycle
A	0006106	biological_process	fumarate metabolic process
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0016829	molecular_function	lyase activity
B	0003824	molecular_function	catalytic activity
B	0004333	molecular_function	fumarate hydratase activity
B	0005576	cellular_component	extracellular region
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006099	biological_process	tricarboxylic acid cycle
B	0006106	biological_process	fumarate metabolic process
B	0009274	cellular_component	peptidoglycan-based cell wall
B	0016829	molecular_function	lyase activity
C	0003824	molecular_function	catalytic activity
C	0004333	molecular_function	fumarate hydratase activity
C	0005576	cellular_component	extracellular region
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006099	biological_process	tricarboxylic acid cycle
C	0006106	biological_process	fumarate metabolic process
C	0009274	cellular_component	peptidoglycan-based cell wall
C	0016829	molecular_function	lyase activity
D	0003824	molecular_function	catalytic activity
D	0004333	molecular_function	fumarate hydratase activity
D	0005576	cellular_component	extracellular region
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006099	biological_process	tricarboxylic acid cycle
D	0006106	biological_process	fumarate metabolic process
D	0009274	cellular_component	peptidoglycan-based cell wall
D	0016829	molecular_function	lyase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE SRT D 1466

Chain	Residue
A	THR186
D	SER319
D	ILE320
D	MET321
D	LYS324
D	ASN326
A	HIS187
B	SER104
B	THR106
B	SER138
B	SER139
B	ASN140
D	GLY317
D	SER318

---

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE SRT C 1466

Chain	Residue
A	SER104
A	THR106
A	SER138
A	SER139
A	ASN140
B	THR186
B	HIS187
C	GLY317
C	SER318
C	SER319
C	ILE320
C	MET321
C	LYS324
C	ASN326

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL B 1467

Chain	Residue
B	SER404
B	PRO406
B	ALA428
B	LEU429
B	LYS433
B	HOH2356
B	HOH2375
B	HOH2411
C	LEU303

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 1468

Chain	Residue
A	SER404
A	SER405
A	PRO406
A	ALA428
A	LYS433
A	HOH2454
A	HOH2517
D	LEU303

---

Functional Information from PROSITE/UniProt

site_id	PS00163
Number of Residues	10
Details	FUMARATE_LYASES Fumarate lyases signature. GSsiMpGKvN

Chain	Residue	Details
A	GLY317-ASN326

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00743","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22561013","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4ADL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ADM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00743","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22561013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27325754","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ADL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ADM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4APB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F92","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"description":"in site B","evidences":[{"source":"HAMAP-Rule","id":"MF_00743","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00743","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22561013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27325754","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ADL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ADM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4APB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F91","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F92","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00743","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22561013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27325754","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ADL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4APB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F91","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F92","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Site: {"description":"Important for catalytic activity","evidences":[{"source":"HAMAP-Rule","id":"MF_00743","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00743","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22561013","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ADM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00743","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22561013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27325754","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ADL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4APB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F92","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---