Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004175 | molecular_function | endopeptidase activity |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006508 | biological_process | proteolysis |
| A | 0007586 | biological_process | digestion |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0097180 | cellular_component | serine protease inhibitor complex |
| A | 0097655 | molecular_function | serpin family protein binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1246 |
| Chain | Residue |
| A | LYS169 |
| A | PRO173 |
| A | GLY174 |
| A | HOH2166 |
| A | HOH2232 |
| A | HOH2236 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1247 |
| Chain | Residue |
| A | SER195 |
| A | SW21252 |
| A | HOH2047 |
| A | HOH2074 |
| A | HOH2297 |
| A | HIS57 |
| A | GLN192 |
| A | GLY193 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1248 |
| Chain | Residue |
| A | PRO124 |
| A | THR125 |
| A | SER127 |
| A | SER146 |
| A | SER147 |
| A | GLY148 |
| A | LYS204 |
| A | HOH2178 |
| A | HOH2203 |
| A | HOH2266 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1249 |
| Chain | Residue |
| A | GLU70 |
| A | ASN72 |
| A | VAL75 |
| A | GLU80 |
| A | HOH2099 |
| A | HOH2100 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 1250 |
| Chain | Residue |
| A | VAL76 |
| A | GLU80 |
| A | PHE82 |
| A | HOH2115 |
| A | HOH2117 |
| A | HOH2299 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO A 1251 |
| Chain | Residue |
| A | ARG66 |
| A | ILE73 |
| A | ASN74 |
| A | VAL76 |
| A | PHE82 |
| A | HIS91 |
| A | PRO92 |
| A | HOH2100 |
| A | HOH2128 |
| site_id | AC7 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE SW2 A 1252 |
| Chain | Residue |
| A | ASP189 |
| A | SER190 |
| A | GLN192 |
| A | SER195 |
| A | SER202 |
| A | TRP215 |
| A | GLY216 |
| A | GLY219 |
| A | CYS220 |
| A | SO41247 |
| A | HOH2237 |
| A | HOH2264 |
| A | HOH2274 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DMS A 1253 |
| Chain | Residue |
| A | LYS87 |
| A | LYS107 |
| A | SER130 |
| A | THR149 |
| A | TYR151 |
| A | HOH2121 |
| A | HOH2185 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC |
| Chain | Residue | Details |
| A | VAL53-CYS58 | |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPVV |
| Chain | Residue | Details |
| A | ASP189-VAL200 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | ACT_SITE: Charge relay system |
| Chain | Residue | Details |
| A | HIS57 | |
| A | ASP102 | |
| A | SER195 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | GLU70 | |
| A | ASN72 | |
| A | VAL75 | |
| A | GLU80 | |
| A | ASP189 | |
| A | GLN192 | |
| A | SER195 | |
