4A9M

N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH N-cyclopentyl-5-(3,5- dimethyl-1,2-oxazol-4-yl)-2-methylbenzene-1-sulfonamide

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE P9M A 1187

Chain	Residue
A	TRP97
B	GLN94
A	PRO98
A	PHE99
A	LEU108
A	LEU110
A	ASN156
A	MET165
A	HOH2059
A	HOH2127

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site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE P9M B 1187

Chain	Residue
A	GLN94
B	TRP97
B	PRO98
B	PHE99
B	LEU108
B	ASN156
B	MET165
B	HOH2039
B	HOH2100

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site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE P9M C 1183

Chain	Residue
A	ASN77
A	GLN80
C	TRP97
C	PRO98
C	PHE99
C	LEU108
C	LEU110
C	TYR113
C	TYR155
C	ASN156
C	HOH2025

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site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 C 1184

Chain	Residue
B	ARG100
B	HOH2012
B	HOH2013
C	ARG128
C	ARG129
C	ASN132
C	TYR134
C	HOH2043
C	HOH2050

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site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1188

Chain	Residue
A	ARG100
A	HOH2019
A	HOH2021

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site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1189

Chain	Residue
A	ARG128
A	ARG129
A	HOH2131

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Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. AwpFrqpvDavklglpDYHkiIkqpMdmgtIkrrlenny..Ywaasecmqdfnt.MftNCyiY

Chain	Residue	Details
A	ALA96-TYR155

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:37731000, ECO:0007744|PDB:8SB6

Chain	Residue	Details
A	ASP112
C	TYR155
C	ASN156
C	LYS157
A	TYR155
A	ASN156
A	LYS157
B	ASP112
B	TYR155
B	ASN156
B	LYS157
C	ASP112

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site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:20048151, ECO:0007744|PDB:2DVQ, ECO:0007744|PDB:2DVS

Chain	Residue	Details
A	ASP160
A	ASP161
B	ASP160
B	ASP161
C	ASP160
C	ASP161

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