Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4A9G

Symmetrized cryo-EM reconstruction of E. coli DegQ 24-mer in complex with beta-casein

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004175	molecular_function	endopeptidase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0006508	biological_process	proteolysis
A	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0042597	cellular_component	periplasmic space
A	0042802	molecular_function	identical protein binding
A	0051603	biological_process	proteolysis involved in protein catabolic process
B	0004175	molecular_function	endopeptidase activity
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005515	molecular_function	protein binding
B	0006508	biological_process	proteolysis
B	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
B	0008233	molecular_function	peptidase activity
B	0008236	molecular_function	serine-type peptidase activity
B	0042597	cellular_component	periplasmic space
B	0042802	molecular_function	identical protein binding
B	0051603	biological_process	proteolysis involved in protein catabolic process
C	0004175	molecular_function	endopeptidase activity
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005515	molecular_function	protein binding
C	0006508	biological_process	proteolysis
C	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
C	0008233	molecular_function	peptidase activity
C	0008236	molecular_function	serine-type peptidase activity
C	0042597	cellular_component	periplasmic space
C	0042802	molecular_function	identical protein binding
C	0051603	biological_process	proteolysis involved in protein catabolic process
D	0004175	molecular_function	endopeptidase activity
D	0004252	molecular_function	serine-type endopeptidase activity
D	0005515	molecular_function	protein binding
D	0006508	biological_process	proteolysis
D	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
D	0008233	molecular_function	peptidase activity
D	0008236	molecular_function	serine-type peptidase activity
D	0042597	cellular_component	periplasmic space
D	0042802	molecular_function	identical protein binding
D	0051603	biological_process	proteolysis involved in protein catabolic process
E	0004175	molecular_function	endopeptidase activity
E	0004252	molecular_function	serine-type endopeptidase activity
E	0005515	molecular_function	protein binding
E	0006508	biological_process	proteolysis
E	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
E	0008233	molecular_function	peptidase activity
E	0008236	molecular_function	serine-type peptidase activity
E	0042597	cellular_component	periplasmic space
E	0042802	molecular_function	identical protein binding
E	0051603	biological_process	proteolysis involved in protein catabolic process
F	0004175	molecular_function	endopeptidase activity
F	0004252	molecular_function	serine-type endopeptidase activity
F	0005515	molecular_function	protein binding
F	0006508	biological_process	proteolysis
F	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
F	0008233	molecular_function	peptidase activity
F	0008236	molecular_function	serine-type peptidase activity
F	0042597	cellular_component	periplasmic space
F	0042802	molecular_function	identical protein binding
F	0051603	biological_process	proteolysis involved in protein catabolic process
G	0004175	molecular_function	endopeptidase activity
G	0004252	molecular_function	serine-type endopeptidase activity
G	0005515	molecular_function	protein binding
G	0006508	biological_process	proteolysis
G	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
G	0008233	molecular_function	peptidase activity
G	0008236	molecular_function	serine-type peptidase activity
G	0042597	cellular_component	periplasmic space
G	0042802	molecular_function	identical protein binding
G	0051603	biological_process	proteolysis involved in protein catabolic process
H	0004175	molecular_function	endopeptidase activity
H	0004252	molecular_function	serine-type endopeptidase activity
H	0005515	molecular_function	protein binding
H	0006508	biological_process	proteolysis
H	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
H	0008233	molecular_function	peptidase activity
H	0008236	molecular_function	serine-type peptidase activity
H	0042597	cellular_component	periplasmic space
H	0042802	molecular_function	identical protein binding
H	0051603	biological_process	proteolysis involved in protein catabolic process
I	0004175	molecular_function	endopeptidase activity
I	0004252	molecular_function	serine-type endopeptidase activity
I	0005515	molecular_function	protein binding
I	0006508	biological_process	proteolysis
I	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
I	0008233	molecular_function	peptidase activity
I	0008236	molecular_function	serine-type peptidase activity
I	0042597	cellular_component	periplasmic space
I	0042802	molecular_function	identical protein binding
I	0051603	biological_process	proteolysis involved in protein catabolic process
J	0004175	molecular_function	endopeptidase activity
J	0004252	molecular_function	serine-type endopeptidase activity
J	0005515	molecular_function	protein binding
J	0006508	biological_process	proteolysis
J	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
J	0008233	molecular_function	peptidase activity
J	0008236	molecular_function	serine-type peptidase activity
J	0042597	cellular_component	periplasmic space
J	0042802	molecular_function	identical protein binding
J	0051603	biological_process	proteolysis involved in protein catabolic process
K	0004175	molecular_function	endopeptidase activity
K	0004252	molecular_function	serine-type endopeptidase activity
K	0005515	molecular_function	protein binding
K	0006508	biological_process	proteolysis
K	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
K	0008233	molecular_function	peptidase activity
K	0008236	molecular_function	serine-type peptidase activity
K	0042597	cellular_component	periplasmic space
K	0042802	molecular_function	identical protein binding
K	0051603	biological_process	proteolysis involved in protein catabolic process
L	0004175	molecular_function	endopeptidase activity
L	0004252	molecular_function	serine-type endopeptidase activity
L	0005515	molecular_function	protein binding
L	0006508	biological_process	proteolysis
L	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
L	0008233	molecular_function	peptidase activity
L	0008236	molecular_function	serine-type peptidase activity
L	0042597	cellular_component	periplasmic space
L	0042802	molecular_function	identical protein binding
L	0051603	biological_process	proteolysis involved in protein catabolic process
M	0004175	molecular_function	endopeptidase activity
M	0004252	molecular_function	serine-type endopeptidase activity
M	0005515	molecular_function	protein binding
M	0006508	biological_process	proteolysis
M	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
M	0008233	molecular_function	peptidase activity
M	0008236	molecular_function	serine-type peptidase activity
M	0042597	cellular_component	periplasmic space
M	0042802	molecular_function	identical protein binding
M	0051603	biological_process	proteolysis involved in protein catabolic process
N	0004175	molecular_function	endopeptidase activity
N	0004252	molecular_function	serine-type endopeptidase activity
N	0005515	molecular_function	protein binding
N	0006508	biological_process	proteolysis
N	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
N	0008233	molecular_function	peptidase activity
N	0008236	molecular_function	serine-type peptidase activity
N	0042597	cellular_component	periplasmic space
N	0042802	molecular_function	identical protein binding
N	0051603	biological_process	proteolysis involved in protein catabolic process
O	0004175	molecular_function	endopeptidase activity
O	0004252	molecular_function	serine-type endopeptidase activity
O	0005515	molecular_function	protein binding
O	0006508	biological_process	proteolysis
O	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
O	0008233	molecular_function	peptidase activity
O	0008236	molecular_function	serine-type peptidase activity
O	0042597	cellular_component	periplasmic space
O	0042802	molecular_function	identical protein binding
O	0051603	biological_process	proteolysis involved in protein catabolic process
P	0004175	molecular_function	endopeptidase activity
P	0004252	molecular_function	serine-type endopeptidase activity
P	0005515	molecular_function	protein binding
P	0006508	biological_process	proteolysis
P	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
P	0008233	molecular_function	peptidase activity
P	0008236	molecular_function	serine-type peptidase activity
P	0042597	cellular_component	periplasmic space
P	0042802	molecular_function	identical protein binding
P	0051603	biological_process	proteolysis involved in protein catabolic process
Q	0004175	molecular_function	endopeptidase activity
Q	0004252	molecular_function	serine-type endopeptidase activity
Q	0005515	molecular_function	protein binding
Q	0006508	biological_process	proteolysis
Q	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
Q	0008233	molecular_function	peptidase activity
Q	0008236	molecular_function	serine-type peptidase activity
Q	0042597	cellular_component	periplasmic space
Q	0042802	molecular_function	identical protein binding
Q	0051603	biological_process	proteolysis involved in protein catabolic process
R	0004175	molecular_function	endopeptidase activity
R	0004252	molecular_function	serine-type endopeptidase activity
R	0005515	molecular_function	protein binding
R	0006508	biological_process	proteolysis
R	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
R	0008233	molecular_function	peptidase activity
R	0008236	molecular_function	serine-type peptidase activity
R	0042597	cellular_component	periplasmic space
R	0042802	molecular_function	identical protein binding
R	0051603	biological_process	proteolysis involved in protein catabolic process
S	0004175	molecular_function	endopeptidase activity
S	0004252	molecular_function	serine-type endopeptidase activity
S	0005515	molecular_function	protein binding
S	0006508	biological_process	proteolysis
S	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
S	0008233	molecular_function	peptidase activity
S	0008236	molecular_function	serine-type peptidase activity
S	0042597	cellular_component	periplasmic space
S	0042802	molecular_function	identical protein binding
S	0051603	biological_process	proteolysis involved in protein catabolic process
T	0004175	molecular_function	endopeptidase activity
T	0004252	molecular_function	serine-type endopeptidase activity
T	0005515	molecular_function	protein binding
T	0006508	biological_process	proteolysis
T	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
T	0008233	molecular_function	peptidase activity
T	0008236	molecular_function	serine-type peptidase activity
T	0042597	cellular_component	periplasmic space
T	0042802	molecular_function	identical protein binding
T	0051603	biological_process	proteolysis involved in protein catabolic process
U	0004175	molecular_function	endopeptidase activity
U	0004252	molecular_function	serine-type endopeptidase activity
U	0005515	molecular_function	protein binding
U	0006508	biological_process	proteolysis
U	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
U	0008233	molecular_function	peptidase activity
U	0008236	molecular_function	serine-type peptidase activity
U	0042597	cellular_component	periplasmic space
U	0042802	molecular_function	identical protein binding
U	0051603	biological_process	proteolysis involved in protein catabolic process
V	0004175	molecular_function	endopeptidase activity
V	0004252	molecular_function	serine-type endopeptidase activity
V	0005515	molecular_function	protein binding
V	0006508	biological_process	proteolysis
V	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
V	0008233	molecular_function	peptidase activity
V	0008236	molecular_function	serine-type peptidase activity
V	0042597	cellular_component	periplasmic space
V	0042802	molecular_function	identical protein binding
V	0051603	biological_process	proteolysis involved in protein catabolic process
W	0004175	molecular_function	endopeptidase activity
W	0004252	molecular_function	serine-type endopeptidase activity
W	0005515	molecular_function	protein binding
W	0006508	biological_process	proteolysis
W	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
W	0008233	molecular_function	peptidase activity
W	0008236	molecular_function	serine-type peptidase activity
W	0042597	cellular_component	periplasmic space
W	0042802	molecular_function	identical protein binding
W	0051603	biological_process	proteolysis involved in protein catabolic process
Y	0004175	molecular_function	endopeptidase activity
Y	0004252	molecular_function	serine-type endopeptidase activity
Y	0005515	molecular_function	protein binding
Y	0006508	biological_process	proteolysis
Y	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
Y	0008233	molecular_function	peptidase activity
Y	0008236	molecular_function	serine-type peptidase activity
Y	0042597	cellular_component	periplasmic space
Y	0042802	molecular_function	identical protein binding
Y	0051603	biological_process	proteolysis involved in protein catabolic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	72
Details	ACT_SITE: Charge relay system => ECO:0000269\|PubMed:21685389

Chain	Residue	Details
A	HIS82
D	HIS82
D	ASP112
D	ALA187
E	HIS82
E	ASP112
E	ALA187
F	HIS82
F	ASP112
F	ALA187
G	HIS82
A	ASP112
G	ASP112
G	ALA187
H	HIS82
H	ASP112
H	ALA187
I	HIS82
I	ASP112
I	ALA187
J	HIS82
J	ASP112
A	ALA187
J	ALA187
K	HIS82
K	ASP112
K	ALA187
L	HIS82
L	ASP112
L	ALA187
M	HIS82
M	ASP112
M	ALA187
B	HIS82
N	HIS82
N	ASP112
N	ALA187
O	HIS82
O	ASP112
O	ALA187
P	HIS82
P	ASP112
P	ALA187
Q	HIS82
B	ASP112
Q	ASP112
Q	ALA187
R	HIS82
R	ASP112
R	ALA187
S	HIS82
S	ASP112
S	ALA187
T	HIS82
T	ASP112
B	ALA187
T	ALA187
U	HIS82
U	ASP112
U	ALA187
V	HIS82
V	ASP112
V	ALA187
W	HIS82
W	ASP112
W	ALA187
C	HIS82
Y	HIS82
Y	ASP112
Y	ALA187
C	ASP112
C	ALA187

site_id	SWS_FT_FI2
Number of Residues	72
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	GLU32
D	GLU32
D	HIS82
D	ASP112
E	GLU32
E	HIS82
E	ASP112
F	GLU32
F	HIS82
F	ASP112
G	GLU32
A	HIS82
G	HIS82
G	ASP112
H	GLU32
H	HIS82
H	ASP112
I	GLU32
I	HIS82
I	ASP112
J	GLU32
J	HIS82
A	ASP112
J	ASP112
K	GLU32
K	HIS82
K	ASP112
L	GLU32
L	HIS82
L	ASP112
M	GLU32
M	HIS82
M	ASP112
B	GLU32
N	GLU32
N	HIS82
N	ASP112
O	GLU32
O	HIS82
O	ASP112
P	GLU32
P	HIS82
P	ASP112
Q	GLU32
B	HIS82
Q	HIS82
Q	ASP112
R	GLU32
R	HIS82
R	ASP112
S	GLU32
S	HIS82
S	ASP112
T	GLU32
T	HIS82
B	ASP112
T	ASP112
U	GLU32
U	HIS82
U	ASP112
V	GLU32
V	HIS82
V	ASP112
W	GLU32
W	HIS82
W	ASP112
C	GLU32
Y	GLU32
Y	HIS82
Y	ASP112
C	HIS82
C	ASP112

site_id	SWS_FT_FI3
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269\|PubMed:21685389

Chain	Residue	Details
A	GLY185
J	GLY185
K	GLY185
L	GLY185
M	GLY185
N	GLY185
O	GLY185
P	GLY185
Q	GLY185
R	GLY185
S	GLY185
B	GLY185
T	GLY185
U	GLY185
V	GLY185
W	GLY185
Y	GLY185
C	GLY185
D	GLY185
E	GLY185
F	GLY185
G	GLY185
H	GLY185
I	GLY185

site_id	SWS_FT_FI4
Number of Residues	48
Details	BINDING:

Chain	Residue	Details
A	THR203
E	LEU242
F	THR203
F	LEU242
G	THR203
G	LEU242
H	THR203
H	LEU242
I	THR203
I	LEU242
J	THR203
A	LEU242
J	LEU242
K	THR203
K	LEU242
L	THR203
L	LEU242
M	THR203
M	LEU242
N	THR203
N	LEU242
O	THR203
B	THR203
O	LEU242
P	THR203
P	LEU242
Q	THR203
Q	LEU242
R	THR203
R	LEU242
S	THR203
S	LEU242
T	THR203
B	LEU242
T	LEU242
U	THR203
U	LEU242
V	THR203
V	LEU242
W	THR203
W	LEU242
Y	THR203
Y	LEU242
C	THR203
C	LEU242
D	THR203
D	LEU242
E	THR203

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)